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안식일 ( Sik Il Ahn ),엄신 ( Shin Eom ),김용기 ( Yong Ki Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),전나리 ( Na Ri Jeon ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
There are two methods to treating onychomycosis. They are oral therapy and topical therapy. In this study we investigated the topical therapy. Penetration enhancer is necessary for effective topical dose of nail. KOH, NaOH and NaBH4 that have a potentiality as a penetration enhancer were dissolved in distilled water at 3% w/v concentration. And then nails are treated with penetration enhancers. The nail swelling rate(%) is calculated by using the nail weight of before and after experiment. The nails treated with penetration enhancer are fully dried and then we observed the surface of nails by using SEM and AFM. The three potential penetration enhancers showed high nail swelling rate and the surface of nails was more lifted than non-treating group or control group. So three penetration enhancers as enhancing the drug penetration are excellent.
안식일 ( Sik Il Ahn ),박상욱 ( Sang Wook Park ),박종학 ( Jong Hak Park ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이한구 ( Han Koo Lee ),신형식 ( Hyung Shik Shin ),이종문 ( John M Rhe 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
5-Fluorouracil(5-FU) has been widely used to treat cancer as types of iv and oral adminstration. However, it induces many side effects and has short half-life time of 10-20 minutes. Furthermore, it has low bioavailability of 20 % due to the hepatic first pass effect. Therefore, we developed novel TDDS using hydrogel and microneedle system. 5, 8 and 10% w/v of Carbopol 940NF was added in hydrogel containing 5-FU to improve permeability. Viscosity of hydrogel increased with increase of Carbopol contents. We applied these novel DDS to hairless mice skin treated and untreated with microneedle system and evaluated drug permeability into skin. The hydrogel containing 8% w/v Carbopol showed best permeability among three groups. We concluded viscosity of drug acts important factor in permeability into skin and bioavailability could be improved through our novel TDDS.
안식일 ( Sik Il Ahn ),엄신 ( Shin Eom ),김용기 ( Yong Ki Kim ),김윤태 ( Yun Tae Kim ),정수현 ( Su Hyun Jung ),김대성 ( Dae Sung Kim ),이준희 ( Jun Hee Lee ),박종학 ( Jong Hak Park ),김원 ( Won Kim ),양재찬 ( Jae Chan Yang ),이종문 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
There are two methods that are administration of oral formulation and application of topical agent for the treating onychomycosis. In this study, drug effectively was penetrated by chemical modification of nail for the topical treatment. For the modification of nail, penetration enhancer, acids, bases, mordants, reducing agents, oxidizing agents etc, have been used. And we calculated the nail swelling(%) by weighing the nails before and after being treated with penetration enhancer and expected the absorption of drug. Moreover we examined the drug absorptivity and changes of nail morphology, according to conducting the fluorescence staining and H&E staining. Finally, it is not easy that drug is penetrated through the nail. Because the nail is made of dead keratin multilayer which is tightly packed. Treated with some penetration enhancers used in this study, we confirmed the effective drug penetration by modifying the nail morphology.
알긴산나트륨함량에 따른 BSA/PLGA미립구에서의 BSA방출거동
구정 ( Jung Ku ),박종학 ( Jong Hak Park ),안식일 ( Sik Il Ahn ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),신형식 ( Hyung Shik Shin ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
We developed the BSA loaded PLGA microspheres using a sodium alginate and water-in-oil-water (W/ O/W) solvent evaporation method for sustaining release of BSA and recognized the release behavior according to sodium alginate concentration. We characterized the surface and the cross-section morphology of prepared PLGA microspheres by the SEM and behavior of BSA release from microspheres for 45 days by BCA assay method. After 45 days, the molecular weight change of PLGA was measured by GPC. The surface of microspheres appeared sphere shape and had may pores. According to sodium alginate concentration increasing, the size of microspheres increased and release rate of BSA from microspheres decreased. These results show that the change of sodium alginate concentration can control the release behaviors.
첨가제에 따른 염산시부트라민 정제의 특성화 및 방출거동
박종학 ( Jong Hak Park ),구정 ( Jung Ku ),안식일 ( Sik Il Ahn ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이종문 ( John M Rhee ),강길선 ( Gilson Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
In this study, sibutramine HCl, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, microcrystalline cellulose(MCC), and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with commercial drug, Reductil. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter( DSC). FT-IR and DSC results demonstrates that structure of drug was changed and crystallinity of drug was decreased according to additives. The dissolution rate of sibutramine HCl from tablet greatly increased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) in case of adding lactose monohydrate and PVP K-25. This study suggest that various pharmaceutical excipients could improve the sibutramine HCl release behaviors.
염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
박종학 ( Jong Hak Park ),엄신 ( Shin Eom ),안식일 ( Sik Il Ahn ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.
수용성 고분자에 따른 실로스타졸 고체분산체의 특성화 및 조절된 방출거동
박종학 ( Jong Hak Park ),김세호 ( Se Ho Kim ),오재민 ( Jae Min Oh ),안식일 ( Sik Il Ahn ),김윤태 ( Yun Tae Kim ),정수현 ( Su Hyun Jung ),최진희 ( Jin Hee Choi ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using general water soluble polymers. We prepared solid dispersed cilostazol with hydrophilic polymer, Poly-N-Vinylpyrolidone(PVP), Plasdone S630, Hydroxypropylmethylcellulose(HPMC), PEG 6000, Eudragit E100, and surfactant, Poloxamer 407. Characterization of cilostazol solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and infrared spectrometry(FT-IR). SEM and DSC were found that amorphous in solid dispersion. Particle size analyzer was used to investigate size of cilostazol in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2). The release behavior of cilostazol was controlled release with hydrophilic polymers and solid dispersed cilostazol with hydrophilic polymers was sustained release behavior than initial burst release of commercial drug(Pletal(R)). This studies suggest that this solid dispersion system with hydrophilic polymers controlled poorly water-soluble drug, cilostazol, release behaviors.
박종학 ( Jong Hak Park ),김세호 ( Se Ho Kim ),안식일 ( Sik Il Ahn ),최진희 ( Jin Hee Choi ),이준희 ( Jun Hee Lee ),김윤태 ( Yun Tae Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee ),강길선 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Poorly water-soluble drug, Raloxifene HCl, is a selective estrogen receptor modulator(SERM) and is currently being used for prevention of osteoporosis in postmenopausal women. We prepared solid dispersion with hydrophilic polymer, polyvinylpyrrolidone(PVP), and surfactant, Poloxamer 407, to improve the solubility of drug. Characterization of raloxifene HCl solid dispersion analyzed by scanning electron microscope(SEM) and Fourier transform infrared spectrometry(FT-IR). SEM and FT-IR were found that raloxifene HCl is amorphous and hydrogen bonding between drug and polymer in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8). The dissolution rate of raloxifene HCl was dramatically higher than commercial drug(Evista(R)). This studies suggest that this solid dispersion system improved the bioavailability of poorly water-soluble drug, such as raloxifene HCl.