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RISS 인기검색어
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- 저자 : 안광필(Ahn, Kwang-Pil) (검색결과 2 건)
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안광필,노준량,김종환,서경필,이영균,Ahn, Kwang Phil,Rho, Joon Ryang,Kim, Chong Whan,Suh, Kyung Phill,Lee, Yung-Kyoon 대한흉부심장혈관외과학회 1976 Journal of Chest Surgery (J Chest Surg) Vol.9 No.2
Anticoagulation therapy with Warfarin and Dipyridamole is useful after prosthetic heart valve replacement for the prevention of thromboembolic accidents. Here presented a case of right ovarian hematoma, 41 years old, female who has been already treated double valve replacement due to mitral insufficiency with 27 mm $Bj{\ddot{o}}rk-Shiley$ mitral, and 29 mm Hancock tricuspid valve successfully on 27th, April, 1976. Just after the operation, patient was treated the anticoagulation therapy with Dipyridamole 300 mg, and Heparin, and later switched to Warfarin 3.75 mg or 5 mg po, as the maintenance dose. Three and half months after the anticoagulation therapy, patient complained the lower abdominal pain and vaginal spotting and which revealed right ovarian hematoma due to ovulation, manifested due to anticoagulation therapy. Patient was discharged postoperative 15 th day with the maintenance dose 5 mg Warfarin and Dipyridamole 300mg po to maintain the prothrombin time 30%, after the uterus and both. ovaries and both adnexae are resected out for the prevention of the further hemorrhage of ovary.
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토끼 동방결절에서의 완만내향전류(i<sub>si</sub>)에 관한 연구
안광필(Ahn, Kwang-Pil),이영균(Lee, Young-Kyun),엄융의(Earm, Yung-E),김우겸(Kim, Woo-Gyeum) 대한생리학회 1986 대한생리학회지 Vol.20 No.2
The voltage clamp studies were undertaken to elucidate the properties of the slow inward current, i<sub>si</sub> in the small preparations of the rabbit sinoatrial node. The slow inward current, i<sub>si</sub> which is known to be responsible for the late one-third of pacemaker potential and whole range of upstroke phase of action potential was analysed with the effects of isoprenaline, cobalt, ouabain and higenamine. The results obtained are as follows; 1) Voltage of SA node preparation was held at zero current level, usually-40mV and the slow inward current, i<sub>si</sub> was activated by depolarizing clamp pulses. Peak values of i<sub>si</sub> in steady state were at -10±0mV in most preparations. 2) Isoprenaline, β-agonist increased i<sub>si</sub> and no shift was noticed in voltage-dependency. 3) Cobalt ion in the concentration of 1 mM abolished is, in entire range of membrane potential and the difference of two current levels before and after Co<sup>2+</sup> treatment could be considered as pure i<sub>si</sub> magnitude. 4) In the therapeutic concentration of ouabain (5 X 10<sup>-8</sup>M) slightly increased is, and reduced the time to reach the peak value. 5) Higenamine (10<sup>-6</sup>M) changed the configurations of action potential (i. e. rapid upstroke phase and notch in the spike) and increase spontaneous rate. It also increased is, and the effect of higenamine was blocked β-blocker, propranolol (10<sup>-6</sup>M).
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