http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
사역산의 항우울효과 및 뇌내 monoamine에 미치는 영향
신화석 ( Hwa Suk Shin ),권영모 ( Young Mo Kweon ),박선동 ( Sun Dong Park ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objective: The purpose of this study was to reseach antidepressant effect and influence on monoamines of Sayuksan which is thought to have some antidepressant according to oriental medicine theory. Methods: We used forced swimming test(FST) to know antidepressant effect of Sayuksan and HPLC to check the influence on monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) of Sayuksan after divided into cerebral cortex, striatum, hypothalamus and hippocampus. Results: In the study of antidepressant effect by forced swimming test(FST) method, Sayuksan had a significant antidepressant effect. In the study of influence on monoamines by HPLC. Sayuksan mainly increased dopamine and serotonin signigficantly among monoamines in 4 parts of rat`s brain above-mentioned. Conclusion: These results suggest that Sayuksan has antidepressant effect that may be related with the increase of dopamine and serotonin as its mechanism.
대황감초음자(大黃甘草飮子)와 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 혈청 조성 및 항산화 효과에 미치는 영향
고원도,곽동걸,신화석,최오철,박선동,Go Won-Do,Gwak Dong-Gul,Shin Hwa-Seog,Choi Oi-Chul,Park Sun-Dong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.
보중익기탕(補中益氣湯), 소음인(少陰人) 보중익기탕(補中益氣湯)과 그 구성약물군(構成藥物群)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)
박선동,고원도,신화석,Park, Seon-Dong,Go, Won-Do,Sin, Hwa-Seok 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1
The purpose of this study was to investigate the effect of Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) and its component groups on diabetes in alloxan induced diabetic rats. Sprague-Dawley male rats weighing $200{\pm}10\;gm$ were randomly assigned to one normal, one control and five experimental groups. The experimental groups was classified into to Bojungikgitang(B1 group), Soeumin bojungikgitang(B2 group), Bogihyulyak(B0 group), Siho-sengma(B1+ group) and Gwakhyang- soyeup(B2+ group). Diabetes was experimentally induced by abdomenal injection of 100 mg/kg of body weight of alloxan. Animals were sacrificed at the 6th day and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In B1, B2 groups the level of glucose was decreased by 39% and 43% compared with that of control group, and in component groups it was decreased by 73%, 81%, and 80% respectively. In fat metabolism, the level of triglyceride and total cholesterol in serum were lower in B1 and B2 groups with high significant difference and had similar tendency in components groups compared with that of control group. The level of HDL cholesterol on serum were increased in B1 and B2 group with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in B1 and B2 group with significant difference, and in component group also increased but with no significancy compared with control group. In kidney function, the level of creatinine group with significant difference, and other compared with control group. In liver function, the level of GOT, GPT, ${\gamma}$-GTP. ALP and bilirubin were lower in B1 and B2 group with significant difference, and in component had similar tendency compared with control group. But in the level of LDH, it was decreased with no significancy. These results indicate that Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) has strong effect on diabetes and it is useful to prevent diabetes, and in component groups the difference between B1+ and B2+ group was not significant.