http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인 염증성 장질환에서 Tumor Necrosis Factor-α와 Interleukin-10 유전자의 다형성에 관한 연구
김태호 ( Kim Tae Ho ),김병관 ( Kim Byeong Gwan ),신형두 ( Sin Hyeong Du ),김지원 ( Kim Ji Won ),김찬규 ( Kim Chan Gyu ),김주성 ( Kim Ju Seong ),정현채 ( Jeong Hyeon Chae ),송인성 ( Song In Seong ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
Although the importance of genetic susceptibility to inflammatory bowel disease (IBD) has been established by epidemiological studies, the genes involved remain poorly understood. The aim of this study was to assess the role of single nucleotide polymorphisms of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) genes in genetic susceptibility of IBD. Methods: Blood samples were obtained from 91 patients with ulcerative colitis (UC), 63 patients with Crohn`s disease (CD), and 200 healthy controls (HC). DNA was extracted from blood leukocytes for IL-10 and TNF-α genotyping by single base extension reaction. Genotypes and allelic frequencies were compared between IBD patients and HC, and among subgroups of the patients. Results: The frequency of -308A allele of TNF-α was significantly lower in CD patients than in HC (p=0.005). The frequency of -238A allele of TNF-α was significantly higher in CD patients with perianal lesion than those without perianal lesion. On the other hand, the frequency of -308A allele of TNF-α was significantly higher in ANCA-positive IBD patients than ANCA-negative IBD patients. There were no significant differences in allelic frequencies in the promoter region of IL-10 between IBD patients and HC. Conclusions: The TNF-α gene polymorphisms at positions -308 and -238 may have influences on the susceptibility to CD or the behavior of CD. (Korean J Gastroenterol 2003;42:377-386)