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신동숙(Dong Suk Shin),오승열(Seaung Youl Oh) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.4
We have studied the stability and transdermal flux of prostaglandin E₁ (PGE₁) from various donor solutions through hairless mouse skin. Stability in HEPES buffer or in propylene glycol (PG) solution where enhancer (oleic acid (OA), propylene glycol monolaurate (PGML), transcutol (TC), ethanol (EtOH)) is dissolved was investigated. PGE₁ was not stable in HEPES buffer. The concentration of PGE₁ decreased continuously for 7 days, and the degradation rate constant was 0.0028 h^(-1), assuming first order reaction. The effect of current or penetration enhancer on the degradation was minimal. Percutaneous transport from HEPES buffer by passive or iontophoretic delivery without enhancer was close to nil. When OA or PGML was used together with PG, both passive and iontophoretic flux increased. PGML showed better enhancing effect than OA. Flux by cathodal delivery was about 2 times larger than that by passive delivery. Flux by anodal delivery was lower than that by passive delivery. TC and EtOH also increased the transdermal flux, but the effect was not as good as that observed when OA or PGML was used. These stability and flux data provide important information on how to formulate the patch, which will be the next step of this work, and on the polarity of current to use during iontophoresis.
고석태(Suk Tai Ko),유강준(Kang Jun Yu),신동숙(Dong Sook Shin),이수연(Soo Hyan Lee) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
This study was performed in order to certify the antidiuretic action and to investigate the mechanism of antidiuretic action of debrisoquin infused into a renal artery in dog. Debrisoquin, when infused into a renal artery, exhibited the antidiuretic action accompanied the reductions of glomerular filtration rate and renal plasma flow, and the decreased amounts of sodium and potassium excreted in urine, limited only to the infused side, while control kidney function remained unchanged at all. The antidiuretic action of debrisoquin infused into a renal artery was blocked by pretreament of prazosin, α₁-adrenergic blocking agent, or reserpine, catecholamine depleting agent. These results suggest that debrisoquin infused into a renal artery elicits antidiuretic action through indirect stimulation of renal sympathetic nerves.
고석태(Suk Tai Ko),유강준(Kang Jun Yu),김순회(Soon Hoe Kim),이은방(Eun Bang Lee),천선아(Seon Ah Cheon),신동숙(Dong Sook Shin),이은심(Eun Shim Lee),김옥경(Ok Kyung Kim),강선영(Seon Young Kang),손문호(Moon Ho Sohn) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
The general pharmacological properties of Artemisia extract powder (DA-9601) produced from Artemisia asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800 ㎎/㎏ po had no influences on general behaviour, barbital sleeping time and motor coordination of mice. The material at the oral dose of 800 ㎎/㎏ did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800 ㎎/㎏ po. In the isolated ileum and trachea of guinea pig, the material did not show direct effect and inhibitory action of chemically or electrically stimulated contraction at the concentration of 2 x 10^(-5) g/㎖ The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of 2 x 10^(-5) g/ml. No influences on blood pressure and respiration were observed at 40 ㎎/㎏ iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120 ㎎/㎏ in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in Na^+ and K^+ excretion.
흰주의 혈압에 영향을 미치는 약물의 작용에 대한 Naproxen과 Arachidonic acid의 영향
고석태,신동숙,은종영 조선대학교 약학연구소 1998 藥學硏究誌 Vol.19 No.1
In order to investigate the influence of naproxen, prostaglandin biosynthesis inhibitor, and arachidonic acid, prostaglandin precusor, on the blood pressure response by drugs such as norepinephrine, angiotensin Ⅱ, acetylcholine and by carotid artery occlusion, this study was preformed in male rats. Naproxen did not influence on the pressor action of norepinephrine. potentiated the pressor action of angiotensin Ⅱ and the carotid artery occlusion, and inhibited the depressor action of acetylcoline Arachidonic acid did not influence on she pressor action of norepinephrine and the carotid artery occlusion, inhibited the pressor action of angiotensin Ⅱ, and potentiated the depressor action of acetylcholine.
오승열,신동숙 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.2
We have studied the transdermal flux of prostaglandin E₁(PGE₁) from a hydrogel patch through hairless mouse skin, to test the possibility of developing a transdermal delivery system. Karaya gum patch containing PGE₁, was prepared by casting method. PGE₁ was stable in the patch for 10 weeks. The effect of current application, enhancer (propylene glycol monolaurate : PGML), adhesive and patch thickness on the flux was studied using side-by-side diffusion cell. Passive flux of PGE₁ was negligible. Cathodal delivery increased the flux about 20 fold. As the concentrations of PGML increased, flux increased. When 5% PGML was used as the enhancer, maximum flux by cathodal iontophoresis was 55 ㎍/㎠·hr. It increased about 2 folds to 100 ㎍/㎠·hr, when the amount of PGML used was 9%. Large increase in flux and the decrease in time to reach maximum flux were observed when the skin was pretreated with neat PGML (maximum flux obtained was about 200 ㎍/㎠·hr). Use of adhesive decreased the flux significantly. To the contrary of our expectation, increase in current density decreased the flux. These flux data together with the stability data indicate that, though the onset of sufficient delivery occur after 1-2 hours of application, therapeutic amount of PGE₁ can be delivered through skin using iontophoresis and penetration enhancer.
이은방,천선아,이은심,김옥경,고석태,유강준,신동숙,강선영,김순회,손문호 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
The general pharmacological properties of Artemisa extract power(DA-9601) produced from Artemisa asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800㎎/㎏ po had no influences on general behaviour, barbital sleeping time and motor corrdination of mice. The material at the oral dose of 800㎎/㎏ did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800㎎/㎏ po. In the isolated ileum and trachea of guinea pig, the material did not show direct effect and inhibitory action of chemically or electrically stimulated contraction at the concentration of 2×10^-5 g/ml. The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of 2×10^-5 g/ml. No influences on blood pressure and respiration were observed at 40㎎/㎏ iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120㎎/㎏ in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in Na^+ and K^+ excretion.