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신동범 제주대학교 환경연구소 1998 환경연구논문집 : 제주대 Vol.6 No.-
In recent years, the safety of foods and food ingredients from genetically modified plant varieties has been widely discussed. Genetical modification technique to transfer genetic information from one species to another has been possible for about two decades. The ability to transform, or insert new DNA into the plant cell, exists now for most crops, including maize, wheat, soybean, cotton, and rice. Early products of this technology include plants with enhanced insect and disease resistance, and improved herbicide tolerance. Future goals are to increase higher yield, improve nutritional and processing characteristics, and produce specialty oils, carbohydrates, and proteins. Some examples of genetically modified products that have been commercialized are FLAVR SAVR™ tomato, Bollgard^㉿ cotton, Round-Up Ready㉿ soybean, Maximizer™ and NatureGard™ corn, Laurical㉿ Canola oil, and Feedom IF" squash. The international agencies. OECD and WHO, and USDA. FDA and EPA in United States issued a policy statement on foods derived from new plants varieties each other. The document from FDA discussed criteria that should be considered by plant breeders and food manufacturers in assessing the safety of foods derived from new plant varieties before they enter the marketplace. Even though genetically modified plants and their foods are now evaluated safe enough by scientific experiments. the present scientific knowledges won't the truth forever. The ultimate judges of new products of biokhnology will be consumers. They will be more confident in the safety of foods derived from plants deveolped by new technology if scientist and developers share information on safety testmg.
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신동범 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-
The biology of aging is still emerging field and, as such, is replete with controversies and contadictions. Although the definition of aging is controversial, in the case of higher animal, it can be defined as a progressive deterioration of biological functions observed only after the organism has attained its maximum reproductive competence. Such age-dependant decline of biological functions involves complex interations among many contributing factors. Among those, oxidative damage caused by oxidative stress is the predominant cause of the age-dependant decline of biological functions. The progressive increase of oxidative stress during aging not only causes oxidative damage to cellular macromolecules, but also modulate the pattern of gene expression through functional alterations of transcription factors. Chronic oxidative stress and inflammatory reaction lead to many age-associated disease such as atherosclerosis and arthritis. Transcription factors that are directly influenced by ROS and proinflammatoy cytokines include nuclear factor kappa B(NF-kB), activator protein 1(AP-1), specificity protein 1(Sp1), peroxisome proliferator-activated receptors(PPARs) and other members of the nuclear receptor superfamily.
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신동범 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-
It is obvious that the Maillard reaction, also called glycation or non-enzymatic glycosylation of proteins by carbohydrates, is related with molecular and cellular lesion in aging and age-related diseases. Aging is characterized by progressive, irreversible and deleterious changes in tissue function. Some of the most pronounced changes occur in tissues with long-lived proteins such as in the extra and intracellular matrix, the lens and the brain. Most of these changes are dramatically worsened by diabetes. By and large, most of the changes observed in aging occur twice faster in diabetes. The importance of the Maillard reaction in aging of living organisms has been appreciated only recently. In the advanced stage of this reaction, advanced glycation endproducts(AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs also induce permanent abnormalities in extra and intracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins.
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스케일불변 특징의 삼차원 재구성을 통한 이동 로봇의 상대위치추정
신동범,길세기,이종실,유제군,이응혁,홍승홍 대한전기학회 2006 전기학회논문지 D Vol.55 No.4(D)
- A key component of autonomous navigation of intelligent home robot is localization and map building with recognized features from the environment. To validate this, accurate measurement of relative location between robot and features is essential. In this paper, we proposed relative localization algorithm based on 3D reconstruction of scale invariant features of two images which are captured from two parallel cameras. We captured two images from parallel cameras which are attached in front of robot and detect scale invariant features in each image using SIFT(scale invariant feature transform). Then, we performed matching for the two image's feature points and got the relative location using 3D reconstruction for the matched points. Stereo camera needs high precision of two camera's extrinsic and matching pixels in two camera image. Because we used two cameras which are different from stereo camera and scale invariant feature point and it's easy to setup the extrinsic parameter. Furthermore, 3D reconstruction does not need any other sensor. And the results can be simultaneously used by obstacle avoidance, map building and localization. We set 20cm the distance between two camera and capture the 3frames per second. The experimental results show ±6cm maximum error in the range of less than 2m and ±15cm maximum error in the range of between 2m and 4m.
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신동범,고재덕,이봉춘,강인정,강항원 한국식물병리학회 2014 식물병연구 Vol.20 No.4
For application of sodium hypochlorite as a seed disinfectant to the control of bakanae disease caused by Gibberella fujikuroi in rice, we investigated the effects of sodium hypochlorite for antifungal activity, eliminating fungus from seeds and reducing disease occurrence in vitro and greenhouse. The viability of the pathogen was significantly reduced at 80 ml/l concentration of sodium hypochlorite, and the pathogens did not grow at over 100 ml/l concentration of sodium hypochlorite. The effect of eliminating fungus was 90% at treatment of 0.3% sodium hypochlorite solution to infected rice seeds for eight hours. When the rice seeds were soaked into 0.5% and 0.3% sodium hypochlorite solutions for twelve hours, the disease incidences of rice seedling were remarkably reduced to 4.3% and 4.7%, respectively, compared to 97.3% of non-treatment control. The rates of seedling stand were 29.1% and 26.9% higher with the sodium hypochlorite treatment than that of non-treatment control. When prochloraz and sodium hypochlorite was treated to naturally severely infested rice seeds with bakanae disease, the disinfection effect was higher than that of prochloraz alone treatment. When the seeds were soaked in sodium hypochlorite before or after prochloraz, the rate of seed contamination was low as 4.0% or 6.3%, respectively, compared to prochloraz alone as 13.7%. The disease incidence was low as 3.7% or 8.3%, respectively, compared to prochloraz alone as 14.3%. The disinfection effect of treatment with prochloraz after sodium hypochlorite was higher than that of treatment with prochloraz before sodium hypochlorite.
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신동범,이선주 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-
The Maillard reaction theory of aging have been proposed in 1980s, hypothesizing that chronic formation and accumulation of Maillard products in biomolecules was a determining factor of the rate of aging of species. Proteins with long life spans serve as the primary targets of exposure to chemical demage, which are detectable n the form of advanced glycation end products(AGEs) and advanced lipoxidation end products(ALEs) as well as modified oxidative reaction by reactive oxygen species are an important factor of age-related damage. The Mallard reaction of DNA also occur in important living organisms. Although measurement of AGEs and ALEs in proteins are useful for determining the rate and extent of Maillard damage, but there are no chemical biomarkers of Maillard damage to DNA. The extent of DNA damage represents a balance between the rate of modification and the rate and fidelity of repair. Damage to DNA accumulates not in the form of modified nucleic acids, but some errors in repair that affect the expression and structure of proteins. Although these mutations are not detectable in DNA by conventional analytical techniques, purines and pyrimidines modified by Maillard reaction intermediates may be detectable in urine, and studies on these compounds should provide insight into the role of Maillard reactions of DNA in aging and disease.
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