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- 저자 : 쉬레스타 아비나쉬 찬드라 (검색결과 2 건)
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Hopea chinensis (Merr.) Hand.-Mazz. 메탄올 추출물이 신경세포에서 아밀로이드 전구 단백질 대사에 미치는 영향
쉬레스타 아비나쉬 찬드라,김주은,함하늘,조윤정,트란 더 바이트,엄상미,임재윤 한국생약학회 2018 생약학회지 Vol.49 No.2
Many plant derived phytochemicals have been considered as the main therapeutic strategy against Alzheimer’s disease (AD). AD is a progressive neurodegenerative disorder, and the most predominant cause of dementia in the elderly. Cholinergic deficit, senile plaque/b-amyloid (Ab) peptide deposition and oxidative stress have been identified as three main pathogenic pathways which contribute to the progression of AD. We screened many different plant species for their effective use in both modern and traditional system of medicines. In this study, we tested that MeOH extract of the stem bark of Hopea chinensis (Merr.) Hand.-Mazz. (HCM) affects on the processing of Amyloid precursor portein (APP) from the APPswe over-expressing Neuro2a cell line. We showed that HCM reduced the secretion level of Ab42 and Ab40 in a dose dependent manner. We found that HCM increased over 1.5 folds of the secretion level of sAPPa, a metabolite of a-secretase. Furthermore, we found that HCM inhibited acetylcholinesterase activity in vitro. We suggest that the stem bark of Hopea chinensis may be a useful source to develop a therapeutics for AD.
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산구절초, 자소엽, 찔레를 함유한 천연 화장품소재의다성분 동시분석과 항산화활성
함하늘,쉬레스타 아비나쉬 찬드라,김주은,이태범,유병완,김민숙,김광상,차준석,이용문,김종엽,임재윤 한국생약학회 2018 생약학회지 Vol.49 No.4
Recently, consumer demand for functional cosmetics containing natural ingredients has been greatly expanded. To develop the natural cosmetic materials, we selected 3 plants, Chrysanthemum zawadskii Herbich (CZ), Perilla frutescens (L.) Britton var. acuta Kudo (PF), and Rosa multiflora Thunberg (RM) which showed high total flavonoid contents (TFC), total polyphenol contents (TPC), and strong DPPH radical scavenging effect. We determined astragalin, chlorogenic acid, and rosmarinic acid as a marker compound for quantitative analysis of the content of each material and standardization of the quality standards and manufacturing standards through LC/MS analysis. HPLC-DAD was used to simultaneously analyze these marker components of three natural product complexes (Mix) and to validate the analytical method through experiments such as linearity, accuracy and precision. The detection wavelengths were set at 210, 265, and 330 nm. The detected 3 compounds from extract of CZ, PF, RM showed significant linearity (R2=0.9947). The limit of detection (LOD) of chlorogenic acid, astragalin and rosmarinic acid were 8.29 µg/ml, 2.28 µg/ml, and 27.00 µg/ml, respectively. The limit of quantification (LOQ) of chlorogenic acid, astragalin and rosmarinic acid were 25.11 µg/ml, 6.92 µg/ml, and 81.83 µg/ml, respectively. The contents of the three indicators of Mix were 19.82-24.71 mg/g of chlorogenic acid, 43.80-46.02 mg/g of astragalin, and 46.33-48.57 mg/g of rosmarinic acid.
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