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한국인 다발성골수종 환자에서 치료에 대한 반응 및 생존기간에 영향을 미치는 예후인자 분석
송헌호(Hun Ho Song),이제환(Je Hwan Lee),박종범(Jong Beom Park),최성준(Seong Jun Choi),김정균(Jeong Kyoon Kim),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),이정신(Jung Shin Lee),김우건(Woo Kun 대한내과학회 2000 대한내과학회지 Vol.58 No.1
Background : New therapeutic modalities such as high dose chemotherapy and stem cell support have been tried to prolong the survival period of the patients with multiple myeloma. However, little is known about the criteria for the application of those new therapies. There are only a few reports for the prognostic factors of multiple myeloma in Korea. The purpose of this study is to analyze the prognostic factors affecting chemotherapy response and survival in patients with multiple myeloma. Methods : We retrospectively analysed the clinical records of 122 patients who were newly diagnosed as multiple myeloma by SWOG criteria, between November, 1989 and April, 1997 at Asan Medical Center. Results : 1) The peak incidence was the 7th decade and male to female ratio was 1.3:1. The most common presenting symptom at first diagnosis was bone pain. 2) Initial clinical stage was as followed: stage I in 17.2% , stage II in 16.4% and 66.4% in III. The immunoglobulin classes were IgG in 51.6%, light chain only in 25.4%, IgA in 16.4%, IgD in 4.1%, and non-secretory type in 2.5%. Plasma cell types in bone marrow were classified as plasmablastic type in 45.9%, plasmacytic type in 54.1%. 3) Eighty two patients who recieved chemotherapy more than 3 cycles were evaluable for chemotherapy response. Overall response rate was 69.5%. Factors affecting response to chemotherapy were serum creatinine level, plasma cell type, total plasma cell percentage and plasmablast percentasge of total nucleated cells in bone marrow. 4) For total 122 patients, overall median survival period was 21 months, and estimated 5 year survival rate was 23.5%. Factors affecting survival were serum creatinine, corrected calcium, albumin, β2-microglobulin level, response to chemotherapy, total plasma cell percentage and plasmablast percentage in bone marrow. Conclusion : Bone marrow findings at initial diagnosis are significantly associated with response to chemotherapy and survival duration.(Korean J Med 58:83-90, 2000)
송헌호 ( Hun Ho Song ),오순옥 ( Soon Ok O ),김수호 ( Su Ho Kim ),문상호 ( Sang Ho Moon ),김진봉 ( Jin Bong Kim ),윤종우 ( Jong Woo Yoon ),구자룡 ( Ja Ryong Koo ),홍경순 ( Kyung Sun Hong ),이명구 ( Myung Goo Lee ),김동준 ( Dong Joo 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Background : Since Plasmodium vivax malaria reemerged in Korea in 1993, a number of patients with malaria have been reported. We analyzed the cases with malaria who lived in Chuncheon and neighboring communities to find out clinical manifestations, laboratory findings and the differences in clinical findings compared to previous studies. Methods : We reviewed the clinical records of the cases who were confirmed as malaria by peripheral blood smear in Chuncheon Sacred Heart Hospital from July, 1998 to Octorber, 2001. Results : Forty-four cases were included. All cases were Plasmodium vivax with high fever, but tertian fever developed only in 15 patients (35.7%). A number of cases showed various symptoms including headache, abdominal pain, nausea, vomiting. Of the all cases, 41 cases (93.2%) developed malaria between June and September. Thrombocytopenia was prominent finding which was noted in 75% of the cases at diagnosis, and recovered during or after treatment. Other laboratory abnormalities such as anemia, elevated transaminases, coagulopathies, and elevated LDH level were also noted. Five patients were performed CSF studies, one patient showed pleocytosis in CSF. Conclusion : We observed that only 15 patients (35.7%) had tertian fever, the others had variable fever patterns. Thrombocytopenia was the prominent findings. Therefore we suggest that malaria should be included in the differential diagnosis of febrile diseases which developed from June to September regardless of the fever patterns. (Korean J Med 63:546-551, 2002) Key Words : Malaria, Fever, Thrombocytopenia
이호권 ( Ho Gwon Lee ),민슬기 ( Seul Ki Min ),공승진 ( Seung Jin Kong ),이수정 ( Su Jung Lee ),송헌호 ( Hun Ho Song ),윤종우 ( Jong Woo Yoon ),이명구 ( Myung Goo Lee ),신동훈 ( Dong Hoon Shin ),강성하 ( Sung Ha Kang ),이정열 ( Jeo 대한내과학회 2005 대한내과학회지 Vol.69 No.2
Background : Tsutsugamushi disease is an acute febrile disease in Korea. Some patients with tsutsugamushi disease have severe illness, which needs care in intensive care unit, and may die due to the disease. We analyzed the cases with tsutsugamushi disease who lived in Chuncheon and neighboring communities to find out clinical manifestations, laboratory findings especially in severe cases. Methods : We reviewed the clinical records of the 81 cases who were diagnosed as tsutsugamushi in Chuncheon Sacred Heart Hospital from April, 1997 to December, 2002. We analyzed the clinical and laboratory findings of the 81 cases, and the treatment results of 79 cases who recieved the treatment in this hospital. We also compared the characteristics of the patients between admission to general ward and intensive care unit (ICU). Results : Seventy three cases developed the disease in autumn. Seventy cases had fever. 58 cases had eschar in their bodies. With the doxycycline treatment, forty five cases subsided the fever within 48 hours, but in 13 cases, fever continued after 5 days of treatment. Twenty five cases were admitted to ICU, 8 cases among them were treated with ventilator, 3 cases died due to the multi-organ failure. When we compared the clinical characteristics of the patients admitted to ICU with those to general wards, leukocyte count, the level of BUN and creatinine were higher, the albumin level was lower in ICU patients than those of general ward patients. Conclusion : Tsutsugamushi disease can progress to severe disease, and be fatal to the patients. So it is necessary to diagnose early and treat carefully. We suggest that leukocyte count, BUN, creatinine, or albumin can be used to predict the prognosis.(Korean J Med 69:190-196, 2005)
혈액종양 : 식도암 환자에서 발생한 항이뇨 호르몬 부적절 분비 증후군 1예
이소연 ( So Yon Rhee ),신성호 ( Sung Ho Shin ),이재혁 ( Jae Hyuk Lee ),안재성 ( Jae Sung An ),도병주 ( Byong Joo Do ),장근두 ( Geun Doo Jang ),송헌호 ( Hun Ho Song ) 대한내과학회 2015 대한내과학회지 Vol.88 No.2
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may be observed in various types of cancer, but is mainly seen in small-cell carcinoma. It can also be caused by several chemotherapeutic agents. However, it is a very rare phenomenon in esophageal cancer or its treatment. We report here on a case of SIADH related to esophageal cancer treatment. A 55-year-old man received chemoradiotherapy (CRT) for esophageal cancer. After receiving CRT for 5 days, he complained of nausea, dizziness, and general weakness, and his sodium level had dropped to 107 mEq/L. His volume status was clinically euvolemic and there were no edema or pigmentation. After hypertonic saline infusion, the sodium level increased and the symptoms improved. There have been several reports of SIADH associated with malignancies or chemotherapy agents. However, to the best of our knowledge, this is the first Korean case of SIADH associated with esophageal cancer that occurred after cisplatin treatment. (Korean J Med 2015;88:231-235)
Fanconi 증후군 치료 후 골동통이 호전된 다발성 골수종
권혜리 ( Hye Lee Kwon ),조성진 ( Seung Jin Cho ),송영수 ( Young Soo Song ),송헌호 ( Hun Ho Song ),오지은 ( Ji Eun Oh ),김수진 ( Soo Jin Kim ),김형직 ( Hyeong Jik Kim ),노정우 ( Jeong Woo Noh ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4
Adult Fanconi syndrome is characterized by variable abnormalities caused by renal proximal transport defects, resulting in glycosuria, aminoaciduria, bicarbonaturia, uricosuria and phosphaturia. A 57-year-old man with κ-light chain multiple myeloma, undergoing chemotherapy with prednisolone and melphalan for 17 month, was admitted with spontaneous femoral neck fracture and was consulted due to polyuria and refractory metabolic acidosis immediately after hemiarthroplasty. The laboratory values showed normal anion gap metabolic acidosis with normal urinary anion gap, hypokalemia, hypouricemia, hypophosphatemia at the time of consultation. After partial correction of acidemia, the fractional excretion of HCO3-was 11.9%, it was interpreted as proximal renal tubular acidosis. 24-hour urine collection showed increased level of excretion for most aminoacids. Diffuse osteopenia and multiple compression fractures on spine were detected on radiological examinations. Also, osteoporosis and osteomalacia was suggested during his clinical course. After the diagnosis of Fanconi syndrome was made, treatment was started with sodium bicarbonate, potassium citrate, calcitriol, calcium carbonate along with phosphate rich diet. Laboratory abnormalities were corrected and refractory multiple bone pain was ameliorated with these treatment.
원위부 신세뇨관 산증에 의한 저칼륨성 주기성 마비로 발현한 Sjogren 증후군
박영환 ( Young Hwan Park ),이경노 ( Kyung No Lee ),송헌호 ( Hun Ho Song ),임미경 ( Mi Kyoung Lim ),조유숙 ( You Sook Cho ),양원석 ( Won Seok Yang ),유빈 ( Bin Yoo ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Distal renal tubular acidosis(dRTA) can be associated with some autoimmune diseases such as systemic lupus erythematosus, Sjogren`s syndrome, and rheumatoid arthritis. Although hypokalemia in Sjogren`s syndrome is a frequent complication, severe symptomatic hypokalemia has been reported only in few cases. Recently we experienced a case of Sjogren`s syndrome diagnosed after the discovery of distal renal tubular acidosis with severe hypokalemia manifestating periodic weakness, myalgia in lower extremities, nausea, vomiting, and flaccid paralysis. She complained continuous sensation of dryness of her eyes and mouth. After the Schirmer`s test, salivary scan, serologic tests, and lip biopsy, Sjogren`s syndrome was confirmed. Intravenous and oral potassium replacement was started immediately, oral sodium bicarbonate later. Marked improvement in periodic paralysis was noted within a few hours and she was fully regained her muscle strength within 48 hours. She discharged with oral sodium bicarbonate and artificial tears. With this treatment blood pH and potassium were kept in the normal range during follow up visits.
하시모토 갑상선중독증 및 휘트르레 선종과 동반된 본태성 혈소판증가증
민슬기 ( Seul Ki Min ),공승진 ( Seung Jin Kong ),이호권 ( Ho Gwon Lee ),신동훈 ( Dong Hun Shin ),송헌호 ( Hun Ho Song ),이성진 ( Seong Jin Lee ),최문기 ( Moon Gi Choi ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Hashitoxicosis, a rare cause of primary hyperthyroidism, is diagnosed by presence of thyrotropin receptor antibody, increased radioiodine uptake and histological finding of lymphoid follicle with lymphcytic infiltration. Thrombocytopenia associated with hyperthyroidism including hashitoxicosis is probably caused by increased destruction of platelets in reticuloendothelial phagocytic system although it is partially compensated by increased production of magakaryocytes in bone marrow. Because essential thrombocythemia in hyperthyroid state has not been reported, most cases of thrombocytosis developed in the treatment of hyperthyroidism are considered as secondary thrombocytosis without any further examination. We experienced fourty-seven year-old woman presenting with palpitation and anterior neck swelling. By endocrinological and histological examinations, she was diagnosed as hashitoxicosis and Hurthle cell adenoma. For evaluation of progressive thrombocytosis, bone marrow biopsy was performed, in which essential thrombocythemia was diagnosed. In summary, we report the first case of an essential thrombocythemia with hashitoxicosis and Hurthle cell adenoma. (Korean J Med 69:S856-S860, 2005)
양측 부신 전이를 동반한 비소세포폐암에서 발현된 부신피질기능저하증
이주용 ( Jue Yong Lee ),공승진 ( Seung Jin Kong ),전만조 ( Man Jo Jeon ),이성진 ( Seong Jin Lee ),송헌호 ( Hun Ho Song ),최문기 ( Moon Gi Choi ),이명구 ( Myung Goo Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Metastatic tumor is the most common malignancy in adrenal glands, and high occurrence of adrenal metastasis is closely related to its rich sinusoidal blood supply. Lung is common origin of metastatic tumor, and 42% of non-small cell lung cancer is associated with metastasis to adrenal glands. In spite of high incidence of adrenal metastasis, metastatic tumor very rarely causes adrenocortical insufficiency possibly because adrenal cortex must be almost completely destroyed before development of adrenocortical insufficiency. Symptoms of adrenocortical insufficiency such as fatigue, generalized weakness, anorexia, nausea, vomiting, abdominal pain are usually nonspecific, and insidiously occur. In addition, these symptoms are often overlooked or misdiagnosed as symptoms of cancer progression, thereby adrencortical insufficiency is not properly managed. We report a 68-year-old man who presented with nonspecific symptoms, and was diagnosed as adrenocortical insufficiency associated with bilateral adrenal metastasis of non-small cell lung cancer by hormonal and radiologic studies including rapid ACTH stimuation test and furosemide challenge test. (Korean J Med 69:S846-S850, 2005)