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RISS 인기검색어
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- 저자 : 송주흥 ( Joo Heung Song ) (검색결과 3 건)
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신장암 환자에서 Pazopanib을 사용한 후 발생한 심부전
이송이 ( Song I Lee ),임병훈 ( Byung Hun Lim ),김영준 ( Young Jun Kim ),강상우 ( Sang Woo Kang ),박철 ( Chull Park ),송주흥 ( Joo Heung Song ),안선호 ( Seon Ho Ahn ) 대한내과학회 2016 대한내과학회지 Vol.90 No.4
A 78-year-old man was diagnosed with renal cell carcinoma, and left nephrectomy was performed. He started pazopanib. One month later, he visited our hospital because of general weakness and dyspnea. His oxygen saturation was low. A chest X-ray showed pulmonary edema and bilateral pleural effusion. An echocardiogram showed a larger left ventricle and lower ejection fraction than observed at the previous examination. The patient discontinued pazopanib and started diuretics and digoxin. His symptoms improved and a follow-up X-ray showed improvement in the pulmonary edema with bilateral pleural effusion. (Korean J Med 2016;90:330-333)
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유지혈액 투석을 받고 있는 만성신부전 환자의 영양 장애에 영향을 미치는 인자
이재홍,안선호,송주흥 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Background: Malnutrition in maintenance hemodialysis(HD) patients has been referred to underdialysis with low protein intake and to metabolic acidosis. However, the respective effects of underdialysis, protein intake and metabolic acidosis have not been clearly demonstrated. To evaluate the role of the dialysis dose, protein intake and metabolic acidosis on nutrition, we measured the predialysis serum HCO₃, pH, serum albumin, PCRn, Kt/V, and BMI in 41 uremic patients on maintenance bicarbonate HD for 66.93±51.86 months. Patients with chronic liver diseases, malignancies, diabetes and cachexia were excluded. Results: Mean age was 46±13 years; Kt/V, 1.22±0.27; PCRn, 0.90±0.16g/kg/day; serum albumin, 4.2±0.21g/dL; BMI, 20.47±2.09kg/m²; HCO₃, 18.4±2.9mEq/L; Serum albumin showed a significant direct correlation with PCRn(p=0.001), and a significant inverse correlation with serum HCO₃(r=0.43, p<0.01) but no correlation with Kt/V and BMI. PCRn showed a significant inverse correlation with serum HCO₃(p<0.irect correlation with Kt/V(p<0.05). Multiple regression analysis confirmed the significant role of protein intake but not of Kt/V and serum bicarbonate, on serum albumin concentrations. Dividing patients into two groups, serum albumin was 4.05±0.34g/dL in those with HCO₃<20mEq/L and 3.95±O.24g/dL in those with HCO₃>20mEq/L. PCRn in the former was 0.94±0.6g/kg/day and in the latter 0.80±0.14g/kg/day(p<0.05). The role of PCRn appeared to be more important than metabolic acidodsis in determining the serum albumin levels. Conclusions: In patients hemodialyzed with relatively adequate Kt/V and whose serum bicarbonate levels maintained within mild acidosis range, PCRn may exert a detrimental effect on serum albumin concentration.
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장거리 달리기 선수에서 횡문근융해와 생화학적 지표의 변화에 대한 연구
김태현,조지현,이영진,나용호,최석채,안선호,송주흥,최석준 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Background: Exercise has almost always been intuitively considered beneficial, but although rewards greatly outweigh risks, exercise occasionally produces bad or even fatal outcomes such as acute renal failure or sudden death. Exertional rhabdomyolysis has been occasionally reported in adult patients following such strenuous activities as military basic training, weight lifting, and marathon running. The purpose of the present study was to investigate whether exertional rhabdomyolysis developed, and how exercise could influence biochemical markers of rhabdomyolysis during resting, exercise, and recovery period in long-distance runners. Methods: Twenty-four young long-distance runners who volunteered to participate in the study, trained with running over 200km every week for 2 to 3 years were studied. Levels of serum creatine kinase(CK), lactate dehydrogenase(LDH), asparatate amino-transferase (AST), and myoglobin, and urine myoglobin were measured at 24hr(pre-exercise period) before, immediately (post-exercise period), and at 24hr(recovery period) after 10km running. Ten long-distance runners who were randomly selected at 24hr after 10km running, including one complaining of calf pain, and age-matched nine young control students were subjected to bone scan with technetiun-99m methylene diphosphonate(99mTc-MDP) Results: Serum CK activities in pre-exercise period were higher than that of the upper normal range. Serum CK and LDH activities were significantly increased in post-exercise period compared with pre-exercise periad(p$lt;0.05), were not decreased to the level of post-exercise in recovery period. The level of serum myoglobin was increased and decreased significantly,(p$lt;O.05, p$lt;0.01, respectively) and urine myoglobin and serum AST activities were remained within nomal range in each period. The mean uptake count of 99mTc-MDP in both lower extremities of runners was significantly greater than that of the control group(p$lt;0.001), and had good correlation with the serurn CK activities of post-exercise, and recovery period(r=0.87 p$lt;0.001, r=0.8 p$lt;0.01, respectively). Conclusion: This study suggests that rhabdomyolysis in the well trained long-distance runners may be developed in low grade, but ongoing injuries during each running. For the diagnosis of rhabdomyolysis in the well trained long-distance runners, serum CK levels are thought to be the most useful marker, and the cut-off value of serum CK levels should be lowered less than usual five times of normal value. A quantitative measurements of 99mTc-MDP uptake with serum CK levels can be more helpful in making the diagnosis of rhabdomyolysis in the well trained long-distanc runners.
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