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黃芩과 黃柏 추출물의 MRSA와 Candida에 대한 항균활성
성인화 한국미생물학회 2004 미생물학회지 Vol.40 No.1
Scutellaria baicalensis and Phellodendron amurense, which have been used traditionally in treatment of many kinds of illness including infectious diseases, were extracted with hexane, dichloromethane, methanol and water, respectively and serially. Antimicrobial activities of the extracts were examined by disk diffusion method. Methanol extract from Scutellaria baicalensis revealed high antimicrobial activities against MRSA, Gmbacteria and Candida albicans, dichloromethnane extract from Phellodendron amurense showed lower activity than the extract of Scutellaria baicalensis. Results suggest that methanol extract from Scutellaria baicalensis could be one of the candidates for new antimicrobial agent against the antibiotic-resistant microorganisms by further steps for the purification, determination of structure and synthesis 항생제 내성균들의 등장으로 새로운 항생제의 개발이 요구되고 있으나 항생제의 개발은 많은 시간과 인력과 개발비를 필요로 한다. 이 문제를 해결하기 위한 방법의 하나로 전통적으로 감염질환의 치료에 사용되어온 식물인 황금과 황백 추출물의 Methicillin-resistant Staphylococcus aureus(MRSA)에 대한 항균활성 보유 여부를 조사하였다. 황금의 메탄올 추출물은 MRSA와 Candida에 대하여 높은 항균 활성을 나타내었으며 황백 추출물보다 활성이 높아 앞으로 새로운 항균제로의 개발 및 사용 가능성이 있을 것으로 보여진다.
신증후 출혈열환자 뇨 침사내 세포에서의 한탄바이러스 항원 증명
성인화 대한바이러스학회 1992 Journal of Bacteriology and Virology Vol.22 No.2
Urine samples were collected from 10 patients diagnosed as hemorrhagic fever with renal syndrome(HFRS) by indirect immunofluorescent antibody test and 3 patients suspected as HFRS but confirmed as not infected by Hantaan virus. Cells in the urine sediments were examined to demonstrate the Hantaan virus antigens by indirect immunofluorescent antibody technique. The following results were obtained: 1. Cells in the urine sediments from 10 HFRS patients collected from day 7 to 40 after onset of HFRS showed Hantaan virus-specific fluorescent spot in their cytoplasms. 2. In samples from 3 suspected patients finally diagnosed as non-HFRS, Hantaan virus-specific antigens could not be found.
Sucrose - Acetone 처리한 한탄바이러스 백신의 안정성
성인화 대한바이러스학회 1994 Journal of Bacteriology and Virology Vol.24 No.2
More then 1,000 patients suffered from hemorrhagic fever with renal syndrome are reported snnually in Korea and 50,000 to 100,000 patients in china, but the effective therapeutic agents and vaccines had not been developed. In 1988, Hantaan virus vaccine was developed and proved effective. This vaccine is a inactivated vaccine, stable for 24 months when stored at 2 8C. In the study, hantaan virus vaccine was treated with sucrose and acetone to make powdered vaccine, and the stability of sucrose-acetone treated vaccine was tested. Immunogenicity of Hantaan virus vaccine containing sucrose in low concentration was main- tained in some degree even after acetone treatment and exposure at room temperature for three months. This results suggest that sucrose could increase the stability of Hantaan virus vaccine and period of storage of Hantaan virus vaccine could be prolonged by adding sucrose and powdering.
성인화 대한바이러스학회 1995 Journal of Bacteriology and Virology Vol.25 No.2
Active immunization against Hepatitis B virus in humans was initially invested by Krugman and collegues between 1971 and 1973 using a crude immunogenic preparation of Hepatitis B virus-containing serum by heat-inactivatiion. These studies led to the development of more sophisticated Hepatitis B vaccines harvested from the plasma of healthy human carriers. But adverse reactions were reported after inoculation of plasma-derived Hepatitis B vaccines. To overcome these problems, vaccine manufactures turned to recombinant DNA technology. Current licensed vaccines of Hepatitis B surface antigen are produced in large fermentation cultures of Saccharomyces cerevisiae yeast cells which carry a recombinant expression vector and plasmid DNA from E. coli. Nearly all the Hepatitis B vaccines manufactured in the world should be stored in the refrigerator to keep the immunogenicity of vaccines for a long time and without refrigeration, vaccines easily lose their immunogenicity. In this studies, as a step to develop the methods of increasing the stability of Hepatitis B vaccine which can be stored for a long period at room temperature or higher temperature conditions, sucrose was added into the vaccines and kept at different temperature conditions. Then the efficacies of vaccines were tested by inoculations of those vaccines into mice and titers of antibody against the surface antigen of Hepatitis B virus were evaluated. The results suggest sucrose could in some degree increase the stability of Hepatits B vaccine.
한탄바이러스를 접종한 쥐의 임파절 , 흉선 및 골수에서 한탄바이러스 항원의 증명
성인화 대한바이러스학회 1991 Journal of Bacteriology and Virology Vol.21 No.1
Lymph nodes, thymuses and bone marrows from SD rats inoculated with Hantaan virus were collected on 1, 2, 4, 6, 8, 10, 12, 20, 30 and 40 days after inoculation of Hantaan virus, and examined by indirect immunoluorescent antibody technique using monoclonal and polyclonal antibodies against Hantaan virus antigens to demonstrate the replication of Hantaan virus in centraI and peripheral immune organs. The results were summarized as follows. 1. Hantaan virus antigens were found in all the thymuses and bone marrows from the day 1 to 40 after inoculation of virus. 2. In the lymph nodes, antigens were found in different stage of infection according to the kinds of lymph node. Antigens were demonstrated on the day 30 and 40 in submandibular nodes, from the day 14 to 40 in parabronchial nodes, from the day 6 to 40 in rnesenteric nodes, and only on the day 14 in iliac nodes. 3. There were no differences of the results between using monoclonal antibody and polyclonal antibody against Hantaan virus antigens. 4. Hantaan virus antigens were not found in tissues from normal SD rats. 5. Identification of cells which had Hantaan virus antigens were not possible under the fluorescent microscope.
성인화 대한바이러스학회 1996 Journal of Bacteriology and Virology Vol.26 No.2
Hantaan virus vaccine was developed in 1988 and proved effective. This vaccine is a kind of inactivated vaccine, stable for two years when stored at 2-8 C. Almost virus vaccines including Hantaan virus vaccine are produced and kept in fluid state, and the immumogenicity can be easily destroyed at room temperature or at higher temperature. Therefore the vaccines should be kept in the refrigerator to maintain the immunogenicity. In this study, glucose and/or lactose was added as a stabilizer into Hantaan virus vaccine to increase the stability and dried in vaccum with ethanol treatment. 5% glucose and or lactose in Hantaan virus vaccine most effectively increased the stability of vaccine and maintained the immunogenicity at least for three months at room temperature. But drying with ethanol treatment did not help increasing the stability. These results suggest that glucose and lactose could be good stabilizer of virus vaccines.