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3-메톡시-6-알릴치오피리다진의 사람 췌장암 세포 사멸작용
강영신(Young Shin Kang),서연원(Yeon Won Suh),권순경(Soon Kyung Kwon),정춘식(Choon Sik Jeong),이용수(Yong Soo Lee) 대한약학회 2005 약학회지 Vol.49 No.4
In this study we investigated the effect of 3-methoxy-6-allylthiopyridazine on cell growth in BxPC3 and PANC1 human pancreatic cancer cells. The treatment with 3-methoxy-6-allylthiopyridazine for 48 h decreased cell viability and induced apoptotic cell death in a dose-dependent manner, assessed by using the MTT assay and the flow cytometry, respectively. These results suggest that 3-methoxy-6-allylthiopyridazine may be a good candidate for the therapeutic management of human pancreatic cancers.
박형근(Hyung Keun Park),윤서영(Seo Young Yoon),최종현(Jong Hyun Choi),고홍숙(Hong Sook Ko),서연원(Yeon Won Suh),이용수(Yong Soo Lee),김건희(Gun-Hee Kim),정미숙(Mi Sook Chung),정재훈(Jae Hoon Cheong) 대한약학회 2006 약학회지 Vol.50 No.6
The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.