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conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death
부문현,이경아,김관회,임병용 대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were induced death by expressing FADD in the absence of tetracycline (FADD-SMC) triggered death of normal SMC. DNA fragmentation and caspase-3 activation were observed in dying SMC by conditioned media. FADD-SMC showed transcriptional activation of tumor necrosis factor (TNF)-α. Conditioned medium contained TNF-α, indicating secretion of the cytokine from dying FADD-SMC. It was investigated if secreted TNF-α was functional. Conditioned medium activated ERK and p38 MAPK pathways and induced MMP-9 expression, whereas depletion of the cytokine with its soluble receptor (sTNFR) remarkably inhibited induction of MMP-9 by conditioned medium. These findings suggest that TNF-α in conditioned medium seems to be active. Then, contribution of TNF-α on death-inducing activity of conditioned medium was examined. Depletion of TNF-α with soluble TNF-α receptor decreased the death activity of conditioned medium by 35%, suggesting that TNF-α play a partial role in the death activity. Boiling of medium almost completely abolished the death-inducing activity, suggesting that other heat labile death inducing proteins existed in conditioned medium. Taken together, these results indicate that SMC undergoing death could contribute to inflammation by expressing inflammatory cytokines and
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배국환,부문현,김성배,한준열 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.7
Rhabdomyosarcoma is one of the commonest soft tissus tumor in children. After the head and neck, genitourinary rhabdomyosarcoma is the second most common site. There are four major types of rhabdomyosarcoma: embryonal, alveolar,pleomorphic, and undir-ferentiated. A subtype of embryonal rhabdomyosarcoma is often denoted by the descrip-tive term $quot;sarcoma botryoides$quot;, because of alayer of spimdle cells pushing up beneath the moucosa in polupoid masses. Rhabdomyosarcoma of the cervix is very rare. Simpson re-viewed 38 cases of cervical sarcoma botryoides from the world literature to 1943. Till nowa-days, total number of the cases in the literature is less than 100. Fruther experiences with a large number of cases are necessary for better management and prognosis. Recently we have experienced a case of rhabdomyosarcoma arising from the uterine cervix. This case is pre-sented with abrief review of the literature.
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배국환,부문현,김성배,동가진 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.8
1989년 1월부터 1991년 12월까지 본 병원 산부인과에서 기능장애성 자궁출혈 환자 139례 대한 임상 및 병리학적 검사에서 다음과 같은 결과를 얻었다. 1. 연령분포는 40대에서 49%, 30대, 50대 순이었고, 평균연령은 41.5세였다. 2. 사과력은 평균 임신횟수가 5.2회였고, 분만횟수는 2,3회였다. 3. 출혈양상은 월경간 출혈이 59례(42.4%), 월경과다가 42례(30.2%)로 많은 빈도를 차지하였다. 4. 자궁내막의 조직학적 소견은 중식기 내막이 54.7% 분비기 내막이 30.2%, 내막중식증이 5.7%순으로 나타났다. 5. 표준화한 월경주기 14일후 자궁내막생검을 시행한 83례중 무배란성 출혈을 보이는 경우가 71% 로 나타났다. Dysfunctional uterine bleeding(DUB)is defined as abnormal bleeding from the uterine endometrium, whic is unrelated to anatomic lesion. According to definition, dysfunctional uterine bleeding seems to be a exclusive term. The problem of abnormal uterine bleeding is the most frequent problem of all gynecologic disease and may ovvur on any age, from menarch to menopause, but occurs more frequently especially on puberty and menopause. it may occur in an ovulatory cycle, although it is more comonly associated with and anovulatory one. 139 cases of dysfunctional uterine bleeding were evaluated on clincal and pathologic aspects, and we performed brief review of literature. The results were as follows: 1. Age distribution of DUB was localized mainly in 30 ∼ 40 years, mean age was 41.5 years. 2. Dysfunctional uterine bleeding patients were mainly multigravidas (mean gravidities ; 5.2 times, mean parities; 2.6 times). 3. Among various bleeding patterns, intermenstrual bleeding was the most common pattern (42%) and the next was menorrhagia (30%). 4. Histologic findings of endometrium were proliferative phases, 76 cases (55%), secretory phase, 42 cases (30%), and hyperplasia, 8 cases (6%) in order of prequency. 5. According to endometrial biopsy, the incidence of anovulatory DUB was 71% (59 cases out of 83 cases) and ovulatory DUB was 29% (24 cases out of 83 cases).
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