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랫트에 있어서 DWH-01(Ranitidine : Bismuth subcitrate : Sucralfate)의 아급성독성에 관한 연구
박선미(Sun Mee Park),김형식(Hyung Sik Kim),김용기(Yong Kee Kim),변수현(Soo Hyun Byung),연제덕(Je Deuk Yeon),유영효(Young Hyo Yu),이병무(Byung Mu Lee),이향우(Hyang Woo Lee) 대한약학회 1993 약학회지 Vol.37 No.4
Subacute toxicities of DWH-01(Ranitidine : Bismuth : Sucralfate = 1.5 : 2 : 6) were inverstigated in Sprague-Dawley rats. After oral administration of DWH-01 with different dosages of 5g/kg, lg/kg, and 0.2g/kg, we examined the number of deaths, general signs, food intake, water intake, body weight and histopatholgical changes for both sexes of rats. During the adminstration period, urinalysis and opthalmological examination were also performed in the treated animals. 1) Animals were all survived for 4 weeks. 2) There were no significant differences in pathological and opthalmological findings between the control and treated animals. 3) There were no significant changes in body weight, food intake and water intake compared with control group. 4) In hematological examination and blood chemical analysis, there was no significant change compared with control group. 5) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group, but it was thought to be caused by environmental factor. These data suggest that DWH-01 is not subacutely toxic in Sprague-Dawley rats.
랫트에 있어서 DWH-01 (Ranitidine:Bismuth subcitrate:Sucralfate) 의 급성독성에 관한 연구
김용기,이향우,김형식,유영효,이병무,이제원,변수현,박선미 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
Acute toxicities of DWH-O1 (Ranitidine : Bismuth : Sucralfate=1.5 : 2 : 6) were investigated in Sprague-Dawley rats. Seven days after oral administration of DWH-O1 with different doses (10 g/kg, 5 g/kg, 2.5 g/kg, 1.25 g/kg, 0.625 g/kg), we examined numbers of deaths, general signs, weight measurement and histopathological examination for both sexes of rats. Summaried results are: 1) No deaths were occurred, 2) There were no pathological and clinical differences compared with control group, 3) No significant changes of body weights were observed, and 4) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group for male and female respectively, but it was thought to be caused by environmental factor. The results suggest that toxicity of DWH-Ol is low and its LD_(50), is over 10 g/kg in Sprague-Dawley rats.