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외상성 비장 손상의 외과적 고찰 및 치료 방법에 대한 비교
배희열 ( Hee Yeol Bae ),정봉화 ( Bong Wha Chung ),이기주 ( Ki Chu Lee ),배수동 ( Soo Tong Pai ) 대한외상학회 1990 大韓外傷學會誌 Vol.3 No.2
Injuries to the speen are commonly encountered by surgeons treating the patients with abdominal trauma. With documentation that overwhelming postsplenectomy infection can occur after splenectomy for trauma, splenic salvage procedure rather than splenectomy have been considered the preferred treatment for traumatic splenic injuries. Splenic salvage has been most often accomplished by splenorrhaphy and more recently by a controversial non-operative approach. This report delineated results with splencetomy, splenorrhaphy and non-operative approach based on 7 years (1984-1990) inwhich 150 consecutive patients with splenic injuries were treated. Results were as follow: 1) The ratio of male to female patients was 2.75: 1 and peak incidence of age was the 3rd decade. 2) The most common cause of splenic injury(52%)was the traffic accident. 3) The most common site of associated trauma is liver(45%)in intraperitoneum and is rib fractures(98%)in extraperitoneum. 4) Of these, 95 patients were treated by splenectomy, 42 patients by splenorrhaphy and 13 patients by non-operative management. 5) Comparative studies of main complication were evaluated by analyzing the values of two groups dividing on each preoperative status concerning to the multiplicity of associated injury, grade of splenic injury and arrival time with X2-test to find higher significance in group of multiple injuries than the opposite group(p< 0.0005). 6) Comparative studies of operative methods were evaluated by analyzing value of two group dividing on duration of operation, amount of transfusion and complica-tion rate with t-test. On result, it was not found any evidence that splenectomy was superior to splenorrhaphy. 7) The overall motality rate was 9.3%.
Effect of Maltol on Metal Ions and Reactive Oxygen Species-induced Lipid Peroxidation
Bae, Hee Youl,Shin, Yong Kyoo,Lee, Chung Soo 중앙대학교 의과대학 의과학연구소 1994 中央醫大誌 Vol.19 No.3
Maltol은 비효소성 지질과산화를 억제한다고 제시되고 있으나, 이들의 항산화 작용기전은 분면하지 않다. 본연구에서는 환원제가 있거나 없는 상태에서 Fe^2+에 의한 또는 Cu^2+와 H_2O_2에 의한 간 마이크로조움의 산화성 손상에 나타내는 maltol의 효과를 관찰하였다. Maltol의 효과를 지질 과산화, Fe^2+의 자가산화와 방응성 산소대사물에 대한 제거작용으로써 조사하였다. Fe^2+ 단독, Fe^2+와 ascorbic acid 그리고 Fe^2+와 NADPH에 의한 마이크로조움의 지질 과산화는 maltol에 의하여 용량에 따라 유의하게 억제되었다. Fe^2+에 의한 지질 과산화는 DETAPAC, EDTA, NTA, SOD, catalase, DMSO, sodium formate와 DABCO에 의하여 억제되었다. Cu^2+와 H_2O_2의 과산화 작용은 maltol, EDTA, penicillamine, catalase, DABCO와 histidine에 의하여 억제되었으나 sodium formate의 영향은 받지 않았다. Fe^2+의 자가산화는 maltol, DETAPAC, EDTA와 NTA의 첨가에 의하여 중지되었다. H_2O_2는 catalase에 의하여 현저하게 분해되었으나 maltol, DETAPAC과 EDTA의 영향은 받지 않았다. Fe^2+와 H_2O_2의 존재하에서 OHㆍ생성은 maltol, DETAPAC, EDTA, DMSO와 sodium formate에 의하여 억제되었으나, 한편 NTA는 유의한 영향을 나타내지 않았다. 이상의 결과로부터 maltol은 금속이온에 대한 킬레이트작용 그리고 OHㆍ과 아마도 산소-금속이온 복합체에 대한 제거작용으로써 환원제와 H_2O_2가 있거나 없는 상태에서 금속이온에 의한 지질 과산화를 포함한 산화성 조직손상을 억제할 것으로 추정된다. Maltol has been shown to inhibit nonenzymatically-induced lipid peroxidation. However, the antioxidant action mechanism of maltol has not been clarified. In this study, effect of maltol on the oxidative injury of liver microsomes caused by either Fe^2+ in the presence or absence of reducing agents or Cu^2+ plus H_2O_2 was investigated. Its effect was studied with respect to lipid peroxidation, autoxidation of Fe^2+ and scavenging action on reactive oxygen species. Fe^2+ alone, Fe^2+ plus ascorbic acid and Fe^2+ plus NADPH-induced lipid peroxidation of microsomes was significantly inhibited by maltol in a dose dependent fashion. Fe^2+ -induced lipid peroxidation was inhibited by DETAPAC, EDTA, NTA, SOD, catalse, DMSO, sodium formate and DABCO> The peroxidative action of Cu^2+ and H_2O_2 was effectively inhibited by maltol, EDTA, penicillamine, catalase, DABCO and histidine but was not affected by DMSO and sodium formate. Autoxidation of Fe^2+ was remarkable decomposed by catalase but was not affected by maltol, DETAPAC and EDTA. Production of OHㆍ in the presence of Fe^2+ and H_2O_2 was inhibited by maltol, DETAPAC, EDTA, DMSO and sodium formate, whereas NTA did not show any significant effect. These results suggest that maltol may inhibit the oxidative tissue injury including lipid peroxidation induced by metal ions with or without reducing agents and H_2O_2 through chelating action on metal ions, iron and copper and scavenging action on reactive oxygen intermediates, such as OHㆍ and probably metal ion-oxygen complexes.