亞鉛이 鉛中毒 白鼠에서 肝및 腎購의 鉛蓄穩과 血中 σ- Aminolevul inic Acid Dehydrase 活性度에 미치는 影響

裵恩相(Eun Sang Bae),林國煥(Kook Hwan Rhim),金榮煥(Young Hwan Kim) 한국환경보건학회 1984 한국환경보건학회지 Vol.10 No.2

The purpose of the study is to determine the effects of Zn in lead poisoning rats by way of examining interaction mechanism of Pb and Zn. The fifty-five rats were Pb divided into four groups such as Zn group, group , Pb and Zn group , and contro1 group. The rats of Zn group and of Zn and Pb group were subdividedinto four groups by dose of Zn respectively ; 250 mglt , 500 mglt , 1,000 mg It and 2,OOOmg/l. The rats having been fed the above mentioned chemica1s, were weighed everγ five days for fifty-five days, and the subjects were slaughtered for measuring ò - ALAD activities in blood and the accumulation amount of the chemicals in livers and kidneys. The resu1ts of the study are summarized as following ; L As for body weight gains , those of the ∞ntrol group rats were the highest , and thoseof Pb group the lowest. 2. ò - ALAD activities of Pb group showed the tendency of decrease in com parison with those of control group. 1n Zn group , the subgroups of 250 mg/l and 500 mg/ 1 showedhigher activities than control group , whereas the subgroups of 1,000 π‘ r; /l and 2,000 mg/l showed lower. 3. Hb value of Pb group was lower than that of control group. 1n Zn group , Hb V8- lue of the groups of 250mg/1 and 500mg/I was a little higher than that of control group , while that of the groups of 1,000 mg/l and 2,000 mg/l was lower.

아질산염이 백서의 간 및 뇌조직중 인지질조성에 미치는 영향

배은상(Eun Sang Bae) 대한약학회 1975 약학회지 Vol.19 No.1

The amount of total lipids and phospholipids in the rat liver and brain after sodium nitrite treatment was measured together with the composition ratio of phospholipids. The results obtained were as follows-. 1) The amount of total lipids and phospholipids was decreased significantly and this decrease was more outstanding in the rat brain than liver. 2) The amount of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin was decreased, whereas that of phosphatidylinositol and diphosphatidylglycerol increased. According to the above described results, it appears that the sodium nitrite treatment of 120mg/kg/day concentration brings inhibition of lipid metabolism in the rat liver and brain.

일부 반면형 호흡기보호구 착용시 안면크기 및 성별에 따른 밀착도 변화

변상훈(Sang-Hoon Byeon),문경환(Kyong-Wahn Moon),손종렬(Jong-Ryeul Sohn),김영환(Young-Whan Kim),배은상(Eun-Sang Bae) 고려대학교 보건과학연구소 2000 보건과학논집 Vol.26 No.1

농작물중(農作物中) 중금속오염도(重金屬汚染度)와 1일섭취량(日攝取量) 및 허용기준설정(許容基準設定)에 관(關)한 연구(硏究)

염용태,배은상,윤배중,Yum, Yong-Tae,Bae, Eun-Sang,Yun, Bae-Joung 대한예방의학회 1980 Journal of Preventive Medicine and Public Health Vol.13 No.1

Certain heavy metals which may lead peoples to poisonous status are widely used in industry and their uses have been increasing along with rapid industrialization of this country. Such an increasement of metal uses aggravates the status of environmental pollution affecting foodstuffs which are the most important life supporting factor of animal and humanbeing. Concerning the safety measures to minimize food-borne transmission of such hazardous metals, surveillance is the backbone of them and probably more so with a potential problem such as intoxication. Theoretically, this surveillance should include the determination of levels of heavy metal toxicants in foods, the determination of food consumption patterns and typical total diet, and the estimation of total load of the metal contaminant from all sources of exposure including air, water, and occupational sources. In recent year, actually, such estimates on the total daily intake of some heavy metals from foods have been made in several developed countries and a wide variation of date by season, locality, and research method was recognized. Also in this country, this kind of research data is vitally needed to make up for the serious shortage or lack of references to estimate the total amount of heavy metal intake of the people. In this study, a modification model for estimation of the total daily intake of cadmium copper, nickel, zinc, and lead through foods was applied and concentrations of the above metals in crops cultivated in this country were measured with atomic absorption spectro photometer to get the following results. 1. Level of heavy metal concentration in crops Generally, the levels of such metals in essential crops such as rice, cucumber, radish. chinese cabbage, apple, pear, grape, and orange are similar or lower than those in Japan and other developed countries. By the way, a striking result on cadmium concentration was increasement of its concentration in rice from $0{\sim}0.035ppm$ in 1970 to 0.11ppm in this study. However, the value is still far below the. Japanese Permissible Lebel of 1.0ppm. 2. Estimation of total daily intake per capita from foods A new model for estimation was devised utilizing levels of metal concentration in foods, amount of food consumed, and other food factors. Based on the above method, the daily intake of cadmium was estimated to be $70.53{\mu}g/man/day$ in average which was as high as the Limit Value of ILO/WHO(up to $71.4{\mu}g/man/day$). Also, 3.89mg of Zinc, 1.65mg of cuppor, 0.32mg of lead were given as the total daily intake per capita by this research. 3. Efficacy of washing or skinning to decrease the amount of metals in crops After washing the crops sufficiently with commercial linear alkylate sulfonate, the concentration of heavy metals could be reduced to $50{\sim}80%$ showing decreasement rate of $20{\sim}50%$. Also, after skinning the fruits, decreasement rate of the heavy metal concentration shelved $0{\sim}50%$.

카드뮴과 Methionine 동시투여(同時投與)가 Mouse장기내(藏器內)의 카드뮴 함량(含量)과 Alkaline Phosphatase활성도(活性度)에 미치는 영향(影響)

유경수,배은상,차철환,You, Kyung-Soo,Bae, Eun-Sang,Cha, Chul-Whan 대한예방의학회 1983 예방의학회지 Vol.16 No.1

This research is to examine the detoxication effect of methionine on cadmium intoxication For this purpose, this paper provides an analysis of the data on the groups of mice (ICR), one group of mice treated with 40 ppm of cadmium only. and other groups of mice combined-treated with cadmium and 0.1%, 0.25%, 0.5% and 1% methionine. After breeding for 40 days, the data on the growth of mice, changes in activation of alkaline phosphatase in blood, and the cadmium content in the liver and kidney, are analysed. The results were as follows: 1) The growth-rate of mice, in the cadmium only injected group, was declined by 9% in comparison with the control group after 40 days. But the two groups of cadmium with 0.5% and 1% methionine showed the rise of 9% ana 14% respectively above the growth-rate of the control group. The results from the groups of cadmium with 0.1% and 0.25%, methionine were similar to that from the cadmium only injected group. 3) Changes in activation of alkaline phosphatase in blood decreased to 86.45% in the cadmium only injected group behind the 100% activation of the control group. The groups of cadmium with 0.1% and 0.25% methionine showed no difference with the former group. But the groups of cadmium with 0.5% and 1% methionine recovered to the 93.14% and 96.08% of activation respectively. 3) The mean content of cadmium in the liver was $0.028{\pm}0.001{\mu}g/g$ in the control group. The cadmium only injected group showed the mean cadmium content of $2.80{\pm}0.62{\mu}g/g$ in the liver, which was similar to $2.82{\pm}1.03{\mu}g/g$ in the group of cadmium with 0.1% methionine, and $2.56{\pm}0.77{\mu}g/g$ in the group of cadmium with 0.25% methionine. But the groups of cadmium with 0.5% and 1% methionine showed the reduction of cadmium contents in the liver to $1.84{\pm}0.56{\mu}g/g$ and $1.74{\pm}0.35{\mu}g/g$ respectively. In the kidney, the groups of cadmium with 0.1%, 0.25% and 0.5% methionine shelved the similar cadmium content to the group treated with cadmium only. But the group of cadmium with 1% methionine showed a small increase to $4.13{\pm}1.00{\mu}g/g$ in comparison with the group treated with cadmium only. This analysis proves that the mobility and diffusion of cadmium in tile tissues advance faster ill the group treated with cadmium and methionine than in the group treated with cadmium only.

위상일관성 이미지 고찰

김영노(Young-Ro Kim),배은상(Eun-Sang Bae) 한국비파괴검사학회 2023 한국비파괴검사학회 춘계학술대회 초록집 Vol.2023 No.5