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인삼 사포닌의 생화학적 연구 ( ⅩⅩⅤ ) : 인삼 사포닌 분획이 대두 발아시 Ascorbic acid 생합성에 미치는 영향
배수경,곽한식,주충노 ( Soo Kyung Bae,Hahn Shik Kwak,Chung No Joo ) 생화학분자생물학회 1986 BMB Reports Vol.19 No.1
It was found that ascorbate synthesized during the germination of Glycine max was always much higher than that of control when the soybeans were rinsed in 10-4% ginseng saponin solution at first for 24 hours and the same solution was poured afterwards. Using the homogenate of germinating soybean (2nd day) as enzyme source and glucose containing [U-^(14)C]-glucose as substrate, it was confirmed that the saponin fraction stimulated the ascorbate biosynthesis during germination. From the radioactivity distribution of the intermediates from glucose to ascorbate. it was realized that ascorbate was synthesized from glucose predominantly via galacturonate pathway rather than glucuronate pathway indicating that the glucose was epimerized first to galactose by the action of UDP-glucose epimerase.
배수경 부산외국어대학교 아세안연구원 2009 Suvannabhumi Vol.1 No.1
This paper aims at scrutinizing how the women's image in the Thai film 'Nang-Nak' has ben represented, afecting the Thai people intensely and achieving its great suces in spite of having the background of 19th century and being a remaker. To fulfil the purpose and analyze the argument, the ideas of Le(1989), Joan(1973) and Jo(196) are used as theoretical concepts for this study. As a result, two images of Thai women sem to be revealed in the movie. The first image, drawn from 'Maen' and 'Mian', is conventional, somewhat ideal type for Thai women, so being a common aspect. What makes the movie a big deal, however, is another image which the heroine 'Nak' has shown, atracting the audience to be moved to tears. It may be aparently an idiosyncratic or extraordinary one from the traditonal point of view in Thailand, but in other sense is a new, fresh image for which the contemporary Thai women want to sek. That is why the movie became one of the most popular in Thailand.
Propylene Oxide로 하이드록시프로필화시킨 감자전분의 이화학적 특성
배수경,이선자,김미라 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.4
Physicochemical properties of potato starches with degree of substitution of 0~0.2645 hydroxypropylation with propylene oxide were examined. Hydroxypropyl group content of the starch was proportional to propylene oxide concentration. Water binding capacity increased but pH decreased with the increase of degree of substitution. Blue value and iodine absorption property decreased with the increase of hydroxypropylation. Differential scanning calorimeter showed that hydroxypropylation lowered the gelatinization temperature of the starch. Relative crystallinity in X-ray diffraction patterns decreased and starch granule observed by scanning electron microscopy was destroyed by hydroxypropylation. This result implied that high level hydroxypropylation affected the crystal region as well as amorphous region of starch.
배수경,손지홍 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
Innovative attempts have been made to overcome nonproductivity and high expenditure in the clinical stages of new drug development. Microdosing studies using subpharmacological doses provide early insight into the body’s disposition toward candidate compounds, and are innovative exploratory trials that can promote productivity in drug development. Highly sensitive analytical technology is crucial in microdosing studies that employ qualitative and quantitative assays of target materials in humans. Accelerator mass spectrometry (AMS) has facilitated the adoption of a human microdosing study in the early phase of clinical drug development. Results derived from AMS microdosing studies using labeled compounds can provide various types of information for candidate selection, including pharmacokinetic characteristics and metabolic profiles of candidate compounds. The applicability of microdosing studies is currently expanding into absolute bioavailability and mass balance studies. Although it remains uncertain whether microdosing adequately predicts the pharmacokinetics of therapeutic doses, further development of microdosing studies using AMS may benefit the field of new drug development and could pose a new challenge to researchers. The use of advanced technology in candidate selection will contribute to improved productivity and competitiveness in pharmaceutical research and development. The introduction of microdosing studies using AMS in Korea will present a newly applicable method for innovative clinical trials and contribute to development potential in global competition.