Baxter Infusor R 를 이용한 경막외 진통제 지속 주입

배상철(Sang Chull Bae),이장원(Jang Won Lee),김일호 대한통증학회 1991 The Korean Journal of Pain Vol.4 No.2

N/A Recently a non-electronic, disposable and portable infusor(Baxter infusor with patient con- trol module, Baxter health care Co., Deerfield IL 60015 USA: BI c PCM) has been developed that will deliver both a continuous drug infusion as well as allow the patient to deliver extra doses of-medication on a demand basis under predetermined limitation of analgesics. Patients may also not require as high analgesic dose rate to control pain when the acceptable and toler- able level of pain relief can be maintained by this device. From April l99l, we have used a total l93 units of BI c PCM. These units consisting of two components which one made by a balloon reservoir(capacity 65 ml, flow rate 0.5 ml/hr) to store medication and to regulate the pump power(490 torr), and another two PCMs to regulate additional analgesic administration by patients demand at intervals of 1S minutes and 60 min- utes. The dose administered to the patient can be varied by changing the concentration of the infusate within the balloon reservoir. These devices were utilized for the pain control of 44 patients. These patients were divided into two groups. Twenty seven cases had cancer pain and 17 cases had non-cancer pain. The Touhy needle(No. l8 G.) tip was inserted into the epidural space and was used to guide the catheter to the spinal nerve level corresponding to the most painful area. The device was connected to the opposite site of the catheter tip and was filled with 60 ml of mixture solution such as 0.5/o bupivacaine 15 ml, morphine HC1 10 mg, trazodone 10 ml, Tridol 3 ml and normal saline 31 ml were administed as the initial dose. When the initial dose was less effective, the next dose could be varied by increasing the concentration of bupivacaine, by adding more morphine (5-10 mg), and by reducing the volume of normal saline. Using these modules of drug self administration, we experienced the following: 1) Improvement of patient's self titration of analgesic requirement was provided. 2) The patients anxiety with pain recurrence resulting from delays in administering pain control medication was decreased significantly. 3) The working load accompanying with the single bolus injection as the usual method was reduced remarkably. 4) There was urinary retention in 5 cases and pruritus in 4 eases which developed as side ef- fects but respiratory depression and vomiting was not encountered in a single case.

대법원 판례를 중심으로 한 기술적 표장의 판단기준에 관한 연구

배상철 ( Sang-chul Bae ) 한국지식재산연구원 2005 지식재산논단 Vol.2 No.2

The mark is not registered because of descriptive mark on Trade Mark, if a specific mark represent quality, use, raw materials, etc. On the other hand, the specific mark which seems to hint or emphasize quality of the designation goods is named suggestive mark. The boundry between descriptive mark and suggestive mark is ambiguous more or less. But the suggestive mark must be distinguished from the descriptive mark, because it can be registered. Whether the specific marks have corresponded to the descriptive marks must consider both conception of mark and figure of that. Therefore, this article tries to observe the judgement standards, centering around Precedents, for example judgement subject, degree, and method, etc. or whether it is described with commonly used methods in terms of judging the descriptive mark.

디자인보호법상 무심사등록제도의 문제점 및 개선방안

배상철 ( Bae Sang Chul ) 한국지식재산연구원 2007 지식재산연구 Vol.2 No.1

Under exam system, KIPO introduced a unexam system to get design-right earily in 1998. In present design-law, double track systems, which substantial exam system is primary and unexam system is secondary are formed. Class of B1, C1, F3, F4, M1 are the unexamined design's articles. Some of item included each class has been superfluous as a unexam design, and the article to specify a unexam design has been appered due to circumstance and technical change. To improve matters of unexam registration system and establish stablily, coordinating unexam design's article is a main subject. Therefore, a study will review the problem of unexam registration system and grope the revision.

상품유사여부 판단에 관한 국내 상표심사실무의 대응 및 과제

배상철 ( Bae Sang Chul ) 한국지식재산연구원 2009 지식재산연구 Vol.4 No.3

As the examiner's conclusion is bound by the rules for the similarity of goods, trademark examiner do not proceed examination individually to determine whether goods are similar to each other when it comes to examination practices. Since the presumption mostly attributes to the valid conclusion, the determination of similarity of goods along with similar group codes gain strength in examinations. The absence of experts who take full charge of goods trade has caused the lack of knowledge and information on the specific trade terms and conditions. Under this circumstance, KIPO has cursorily and indiscriminately conducted classification of goods and similar group codes that hardly reflected real goods trades from now on. In this regard, the similar group codes have limitations to catching up with the changes in goods and service industries according to the industry development and the changing culture. Considering the classification of goods is the rigid classification system that can not promptly respond to the market changes, it is imperative that the enhanced classification system should be designed to quickly reflect the ever changing market conditions in which new products are on the markets day by day.

국내 류마티스 질환의 유병률 조사 현황

배상철 ( Sang Cheol Bae ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.1

D - Penicillamine 에 의한 중증 근무력증 1 예

배상철(Sang Cheol Bae),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),장대국(Dae Kuk Chang),윤석진(Seok Jin Yoon),장대일(Dae Il Chang),김명호(Myung Ho Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.2

In the D-penicillamine induced myasthenia gravis, ptosis and diplopia may occur usually six to seven months after starting therapy. Muscular weakness is usually improved two to three months after discointinuing D-penicillamine without any treatment. The pathogenesis of drug induced myasthenia is not clear. The antiacetylcholine receptor antibody is noticed to be increased presumably due to altered immunological reactivity. The patient was a 52-year-old woman who had had rheumatoid arthritis for 5years. After four months of D-penicillamine therapy (500mg/day), she began to be suffered from diplopia and left ptosis. A tensilon test was positive. HLA DR1 was positive. Electromyographic finding was normal. No antibody to acetylcholine receptor was detected. Four months after cessation of D-penicillamine therapy symptoms and signs disappered without any treatment. We experienced a case of rhematoid arthritis with D-penicillamine induced myasthenia gravis in a 52-year-old female and report this with a review of literature.

전신성 류마티스 질환에서 항 ENA 항체에 관한 연구

배상철(Sang Cheol Bae),송관규(Gwan Gyu Song),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Thin Kyou Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

Objectives: Among a variety of nuclear antigens, extractable nuclear antigens(ENA) which can be extracted from nuclei by homogenization in neutral saline contain ribonucleoprotin, Sm, SS-A/Ro, SS-B/La and other antigens. Characterization of anti-ENA anti-bodies provides information about nosology, subset definition within diseases, clinical activity, specific organ involvement and prognosis. Methods: Authors have used double immunodiffusion test to detect antibodies to ENAs and studied the frequencies of autoantibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Results: 1) 1,063 patients were investigated for the presence of serum antibodies to ENAs and 180 out of 1,063 patients (16.9%) had anti-ENA antibodies. 3,412 tests were performed for the presence of antibodies to Sm, RNP, Ro, La, Scl-70 and Jo-1 respectively and 230 out of 3,412 tests (6.7%) were positive. 2) The profiles of 137 patients who had anti-ENA antibodies are systemic lupus erythematosus (61), rheumatoid arthritis with secondary Sj6gren's syndrome (26) and without secondary Sjogren's syndrom (9), mixed connective tissue disease (18), scleroderma (10), polymyosits/dermatomyositis (6), undifferentiated connective tissue diease (4), gout (1), fibromyalgia syndrome (1) and Hashimoto's thyroiditis (1). 3) The frequencies of antibodes to ENAs were 73.5% in patiets with systemic lupus erythemtosus, 9.6% in rheumatoid arthritis, 100% in mixed connective tissue disease, 71.4% in scleroderma and 46.2% in polymyostis/dermatomyositis. 4) The frequencies of antibodies to Sm, RNP, Ro and La in patients with systemic lupus erythematosus were 18.1%, 41.5% 43.9% and 4.9% respectively. (1) Patients with anti-Sm antbodies had a higher incidence of pleuritis than those without anti-Sm antibodies(p=0.029). (2) Patients with anti-RNP anibodies had a higher incidence of Raynaud's phenomenon and pleuritis and a lower incidence of renal disease than those without anti-RNP antibodies (p=0.008, p=0.019, p=0.029). (3) Patients with anti-Ro antibodies had a higher incidence of thrombocytopenia than those without anti- Ro antibodies. (4) There were no clinical and laboratory differences between patients with anti-La antibodies and without anti-La antibodies. 5) In patients with rheumatoid arthritis, anti-Ro anti-body was likely to be associated wih secondary Sjogren syndrome, although statistically significant association was not found (p=0.063). Conclusions: These results showed that the detection of antibodies to ENAs by double immunodiffusion test was expected to be a useful diagnostic marker and predict some clinical features in systemic rheumatic diseases.

Human Adjuvant Disease 의 임상적 고찰

배상철(Sang Cheol Bae),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),최희윤(Hee Youn Choi),주경빈(Kyung Bin Joo) 대한내과학회 1992 대한내과학회지 Vol.43 No.2

Background: Human adjuvat disease means the autoimmune disease or autoimmune disease like syndrome developed after plastic surgery using foreign body implantation. After 1st report of HAD by Miyoshi at 1964, a number of cases have been reported especially from Japan. However, there has been no report regarding HAD in Korea. Authors report 12cases of HAD which were experienced recently, Methods: 12patients who represented autoimmune disease or autoimmune disease-like syndrome after plastic surgery using foreign body implantation were evaluated clinically. Results: 1) The mean interval from plastic surgery to onset of HAD was 14.9years. 2) Eight of tweleve patients had undergone rhinoplasty and paraffin was most frequently used. 3) Seven of our patients were given the diagnosis of rheumatoid arthritis and the others were unclassified HAD. 4) Five patients underwent the operation to remove foreign material, Only one was improved. Conclusion: In korea, there has been done a number of plastic surgery using paraffin or silicone, So we have to concern about HAD after plastic surgery using foreign body implantation.

전신성 류마티스 질환에서 항인지질항체에 관한 연구

배상철(Sang Cheol Bae),정성수(Sung Soo Jung),송관규(Gwan Gyu Song),이인홍(In Hong Lee),장현규(Hyun Kyoo Jang),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Think You Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5

Objectives: The antiphospholipid antibodies (APA) are associated with a clinical syndrome of vascular thrombosis, thrombocytopenia, recurrent fetal loss and neurological manifestations. This has been studied by several investigators for systemie lupus erythematosus but no systematic study has been reported for the correlation between a variety of systemic rheumatic diseases including rheumatoid arthritis and antiphospholipid antibodies in Korea. Methods: Authors have used enzyme-linked im-munosorbent assay (ELISA) to detect antibodies to phopholipids and studied the frequencies of antibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Resulta: 1) 206 patients were investigated for the presence of antibodies to phopholipids and 25 out of 206 patients (12. 1%) had antiphospholipid antibodies. 2) The frequencies of antibodies to phopholipids were 20.7% in patients with systemic lupus erythematosus, 12.3% in rheumatoid arthritis and 16.7% in mixed connective tissue dsease but antibodies to phospholipids were not detected in ankylosing spondylitis, polymyositis/ dermatomyositis, undifferentiated connective tissue disease and Behcet's disease. 3) In patients with systemic lupus erythematosus, no significant association was found between antiphos-pholipid antibodies and clinical and laboratory features except thrombocytopenia and anti-Ro antibody (p=0.003, p=0.036). But patients with antiphopholipid antibodies were likly to have a higher incidence of malar rash, photosensitivity, alopecia, neurologic manifestation, renal disorder, fetal loss and thrombosis than those without antiphospholipid antibodies. 4) In patients with rheumatoid arthritis, no significant association was found between antiphospholipid antibodies and clinical and laboratory features. Conclusions: These results showed that the detection of antibodies to phospholipids by ELISA was expected to be useful as a screening test and suggested that antiphospholipid antibody found in rheumatoid arthritis patients differed from that seen in systemic lupus eryth-ematosus patients. Further studies into the fine specificity of antiphospholipid antibody in various systemic rheumatic diseases are needed.

금속 수소화물을 이용한 수소공급시스템

배상철(Bae, Sang-Chul),승전정문(Katsuta, Masafumi) 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.06

To find out the optimum design of hydrogen storage and supply tank using Metal Hydride (briefly MH) and to make clear the performance characteristics under various conditions are our research purpose. In order to use the low-temperature exhaust heat, LaNi_{4.7}Al_{0.3} which operates under the low pressure of 1 MPa is chosen, and we measure the basic properties, namely density, specific heat, PCT(Pressure-Concentration-Temperature) characteristics, and effective thermal conductivity. Then, a numerical calculation model of hydrogen storage using MH alloy is suggested and this thermal diffusion equation of model is solved by the backward difference method. This calculation results are compared with the experimental results of the systems which installed 1kg MH alloy and, it is found out that our calculation model can well predict the experimental results. By the experimental using MH alloy, it is recognized that the hydrogen flow rate can control by the step adjustment of brine temperature.