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호르몬 대체요법 혹은 칼슘 보충제로 치료한 초기 폐경기 여성에서 골밀도 변화에 대한 골대사 생화학적 지표의 유용성
배광범(Kwang Bum Bai) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2
Objective : To identify the effectiveness of bone turnover indexes for bone loss or gain in early postmenopausal women. Method : This study was performed in 240 menopausal women(mean age, 50 yr), who were randomized to hormone replacement therapy(HRT) or calcium supplementation(CS, 500mg/day) for 1yr. Urinary N-telopeptide(NTx) and osteocalcin(OC), as well as spine and femoral neck bone mineral density(BMD) were measured at baseline and 1, 3, 6, 12 months after treatment. Results : Women receiving HRT(n=110) showed a significant increase in spine BMD(+2.6% ; P<0.0001) and hip BMD(+1.1% ; P<0.05) compared to women receiving CS, who showed a decline at both sites (-1.0% ; P<0.01). Both markers showed time dependent decreases in women receiving HRT(P<0.001) and no change in women receiving calcium alone. When baseline indexes of turnover were divided by quartile, there was a significantly greater increase in BMD among those with the highest NTx, OC levels compared to that in those with the lowest NTx, OC levles(P<0.05). When subjects receiving HRT were compared by their positive or negative skeletal response at 1yr and their baseline turnover marker, initial NTx values were significantly higher in those that gained bone than in those that lost bone (P<0.001). Calcium supplementation women in the highest quartile for NTx at baseline had significantly greater decreases in spine BMD than subjects with the lowest NTx values(P<0.005). Conclusions : For early postmenopausal women there are differential responses of biochemical markers to HRT and calcium supplementation. Baseline urinary NTx and serum osteocalcin were good predictors of change in spine BMD after 1yr of either HRT or calcium supplementation. It is concluded that markers of bone formation and resorption can be used clinically to predict future BMD in early postmenopausal women.
체외수정시술 환자에서 난소 주위 유착이 과배란유도 중의 난소 난포 발달에 미치는 영향에 관한 연구
배광범,김석현,이진용,Bai, Kwang-Bum,Kim, Seok-Hyun,Lee, Jin-Yong 대한생식의학회 1988 Clinical and Experimental Reproductive Medicine Vol.15 No.2
It has been suggested that the presence of periovarian adhesions might impair the ovarian response to gonadotropins. Total 136 patients who underwent IVF-ET from February to June 1988(88-1 and 88-2 series) at SNUH were classified into three groups according to total ovarian access score, sum of each ovarian availability, estimated by diagnostic laparoscopy : group I(N=43,0%-50%), group II(N=49, 50%-150%) and group III(N=44, 150%-200%). To evaluate the effects of periovarian adhesions on follicular development in controlled ovarian yperstimulation for IVF-ET, serum E2 levels on the day of hCG dministration (Day 0) and the day after hCG administration (Day+1), the number of ovarian follicles with mean diameter${\geqq}$12mm on Day 0, and the number of oocytes retrieved by transvaginal aspiration were measured and compared among groups. There were no significant differences in age of patients, cancellation rate due to inadequate ovarian response, serum E2 levels, the number of ovarian follicles, the number of oocytes retrieved, and oocytes retrieval rate per follicle. In the same patients(N=31) in group II in whom the difference in ovarian availability between two ovaries is more than 50%, there was also no significant difference in the number of ovarian follicles between them. These data suggest that pelvic adhesions including periovarian adhesions have no adverse effects on the ovarian response to gonadotropins stimulation and the outcome of IVF-ET.
배광범,김정구,문신용,이진용,장윤석,Bai, Kwang-Bum,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1986 Clinical and Experimental Reproductive Medicine Vol.13 No.2
The present study was designed to assess the relationships between the methods to evaluate adequacy of luteal function. We measured mid-luteal serum progesterone levels by radioimmune assay, luteal phase lengths and mean post-ovulatory basal body temperature rise rates by basal body temperature charts in 40 in-phase-cycle infertile patients and 38 out-of-phase-cycle patients who underwent late-luteal endometrial biopsies at the sterility clinic of Department of Obstetrics and Gynecology, Seoul National University Hospital from Jan. 1986 to Aug. 1986. The results were summarized as follows: 1. No significant differences were found in mean age, mean duration of infertility, mean mid-luteal serum progesterone levels, and mean post-ovulatory temperature rise rate between in-phase-cycle patients and out-of-phase-cycle patients, but significant difference in mean luteal phase length between 2 groups was identified. 2. 91% of total patients sho had luteal phase lengths of less than 11 days showed out-of-phase-cycles. 3. In out-of-phase-cycle group with luteal phase lengths of less than 11 days, 50% had an endometrial lag of at least 4 days, but 10.7% had an endometrial lag of 4 or more days in group with luteal phase lengths of more than 11 days. 4. There was no significant correlation between mid-luteal serum progesterone level and endometrial lag of late luteal phase endometrial biopsy.
난소적출술 환자에서 Estrogen 단독요법 및 Estrogen-androgen 병합요법에 관한 연구
배광범,Bai, Kwang-Bum 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4
Objective : To evaluate the difference between estrogen only therapy and estrogen-androgen combination therapy in surgical menopause patients. Materials and Method: Surgical menopause patients received 0.625 mg conjugated equine estrogens or 0.625 mg conjugated equine estrogens plus 1.25 mg methyltestosterone for 2 years. Bone mineral density, menopausal symptoms, lipoprotein profiles were measured. Results: Both groups showed increased bone mineral density. In the combination group, total cholestero l, high density lipoprotein cholesterol and triglycerides decreased. In the estrogen only group, low density lipoprotein cholesterol decreased but high density lipoprotein cholesterol increased significantly. In both groups, menopausal symptoms were much improved. Side effects were easily tolerated in both groups. Conclusions: Estrogen-androgen combination therapy had comparable benefits compared with estrogen only therapy.
과체중 및 비만 다낭성 난소 증후군 환자에서의 Metformin과 Rosiglitazone의 효용성
배광범,Bai, Kwang Bum 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.4
Objective: The purpose of this study was to evaluate and compare the effects of metformin and rosiglitazone in overweight or obese women with polycystic ovarian syndrome. Methods: Twenty Six overweight or obese patients with polycystic ovarian syndrome were randomly treated with either metformin (500 mg three times daily, n=13) or rosiglitazone (4 mg once daily, n=13) for 6 months. Hormonal studies were performed before and after treatment. Insulin resistances were calculated by computerized HOMA 2 Calculator v2.2. Results: Testosterone decreased while SHBG increased after 6 months treatment in both metformin and rosiglitazone treatment groups. Fasting glucose decreased after metformin or rosiglitazone treatment. HOMA insulin resistance improved after treatment with either drug. There was no differences in hormonal changes and insulin resistance between 2 treatment groups. Conclusions: This study shows that metformin and rosiglitazone are effective in improving insulin sensitivity and ameliorating hyperandrogenism in overweight/obese polycystic ovarian syndrome women.
자연폐경 여성에서 골량감소 예측에 있어서 혈청 인슐린유사 성장인자들의 유용성에 관한 연구
안귀범(Ki Bum Ahn),김정구(Jung Gu Kim),배광범(Kwang Bum Bai),이진용(Jin Yong Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
Objectives : To evaluate if circulating insulin-like growth factors(IGFs) levels may provide an indirect information on the microenvironment in bone expressed as bone minerial density(BMD). Methods : IGF-I and IGF-II were measured by radioimmmunoassay after Bio-gel P-10 preparation of serum samples obtained from natural postmenopausal women(n=146) and normal healthy premenopausal women(n=43) and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. Results : In natural postmenopausal women age or menopause duration correlated negatively with serum IGF-I and BMD at all skeletal sites measured while body mass index(BMI) correlated positively. However, there was no significant correlation between serum IGF-II and these demographic parameters, and between serum IGF-II and BMD. When multiple regression analysis was performed including age, BMI, menopause duration and serum IGF-I as independent variables, serum IGF-I was an independent predictor of BMD at the lumbar spine, trochanter and Ward's triangle. Serum IGF-1 levels were significantly lower in postmenopausal women with osteoporosis than in normal premenopausal women and postmenopausal women with normal BMD or osteopenia. Serum IGF-II levels did not show any difference among these groups. The sensitivity of serum IGF-I assay in determining osteoporosis was 67 %, while the specificity was around 70%. Conclusions : Circulating IGF-I measurements may be useful as a screen method in identifying women with osteoporosis and at risk for osteoporosis.
임신중절에 대한 사회적 여건 변화에 따른 임신 중기 양수검사의 감소
전혜원 ( Hye Won Jeon ),이택상 ( Taek Sang Lee ),배광범 ( Kwang Bum Bai ),황규리 ( Kyu Ri Hwang ),김병재 ( Byung Jae Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.12
Objective: To investigate the effect of alteration of social conditions towards pregnancy termination on the acceptance of genetic amniocentesis. Methods: Retrospective review of medical records was conducted for women (<20 weeks` gestation, singleton pregnancy) who visited our outpatient department between February 1, 2009 and August 31, 2010. Acceptance of genetic amniocentesis was compared between two groups of women: one from February 1, 2009 to November 30, 2009 (2009 group) and the other from December 1, 2009 to August 31, 2010 (2010 group) after strict regulation of pregnancy termination. The acceptance rate of those who were referred to our center for genetic amniocentesis in same time period was also evaluated. Results: Overall, 19 of 101 (19%) women in the 2009 group and 10 of 93 (11%) in the 2010 group, opted for invasive diagnostic methods (P=0.16). Women > 35 years in the 2010 group (5/30, 17%) were less likely to accept genetic amniocentesis than 2009 group (15/30, 50%; P=0.01). Similar results were observed in those who were indicated for genetic amniocentesis. (9/35, 26% vs 19/34, 56%; P=0.02). Acceptance rate of genetic amniocentesis was increased for those who were referred from private clinic, but without statistical significance (15/21, 71% vs 13/14, 93%; P=0.20). Conclusion: After strict regulation of pregnancy termination, acceptance rate of genetic amniocentesis was significantly decreased among women who had increased risk for chromosomal abnormalities or neural tube defect at our center. Whereas, there were no significant change in acceptance rate for those who were referred for amniocentesis from private clinic.
최영민 ( Young Min Choi ),손유경 ( Yoo Kyung Sohn ),김태준 ( Tai Jun Kim ),구승엽 ( Seung Yup Ku ),배광범 ( Kwang Bum Bai ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),김정구 ( Jung Gu Kim ),문신용 ( Shin Yong Moon ),이진용 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
Objective : To explore the efficacy of serum CA19-9 determination for the detection of endometriosis. Designs : A retrospective analysis Materials and Methods : Preoperative serum CA19-9 and CA125 concentrations were measured in 53 patients with surgicall
최수희 ( Soo Hee Choi ),최영민 ( Young Min Choi ),박성효 ( Sung Hyo Park ),장은란 ( Eun Ran Chang ),배광범 ( Kwang Bum Bai ),양세원 ( Se Won Yang ),김석현 ( Seok Hyun Kim ),설혜원 ( Hye Won Seol ),오선경 ( Sun Kyung Oh ),문신용 ( 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
Existence of Y derived chromosome in Turner patients is significant due to the risk of gonadoblastoma development, but cytogenetic analysis may fail to detect low levels of Y chromosomal materials. Recent studies using PCR based methods showed higher sens
난자 세포질내 정자 주입술을 이용한 체외수정시술시 누적임신율에 관한 연구
김석현(Seok Hyun Kim),심순섭(Soon Sup Shim),지병철(Byung Chul Jee),최성미(Sung Mi Choi),김희선(Hee Sun Kim),류범용(Buom Yong Ryu),오선경(Sun Kyung Oh),서창석(Chang Suk Suh),최영민(Young Min Choi),배광범(Kwang Bum Bai),김정구(Jung Gu 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
Objective : To evaluate the cumulative pregnancy rate(CPR) of in vitro fertilization and embryo transfer(IVF-ET) with intracytoplasmic sperm injection(ICSI). Methods : Medical records of 260 infertile patients undergoing 519 cycles of IVF-ET with ICSI from January, 1994 to December, 1999 were retrospectively reviewed. The CPR beyond 12 weeks of gestation was estimated by Kaplan-Meier method. The CPRs were compared by log-rank test between groups divided by age of patients, indication of ICSI, and method of sperm retrieval for ICSI. Results : As 70 patients achieved an on-going pregnancy after IVF-ET with ICSI, the PR was 26.9% per patient and 13.5% per cycle. The overall CPR was 54.9% after 6 cycles of IVF-ET with ICSI. As expected, age had a significant strong effect on the CPR; CPRs afer 4 cycles of ICSI were 61.8% in the age group of 30 years(n=81), 43.7% in 31-35 years(n=106), and 15.3% in 36 years(n=73). There was no significant difference in the CPR between abnormal semen analysis group(n=184) and prior low fertilization rate group(n=66). In abnormal semen analysis group, the CPR of surgically retrieved sperm subgroup(n=60) was not significantly different from that of ejaculated sperm subgroup(n=124). Conclusions : The CPR of IVF-ET with ICSI was presented, and it could be of much help in the clinical counseling of IVF-ET patients. ICSI technique could be used successfully for IVF-ET in infertile couples who had the male factor infertility or the past history of low fertilization rate in the previous cycles.