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Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability
박천권,허범강,김세나,이승호,홍혜림,최영빈 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
To enhance oral drug bioavailability, we propose mucoadhesive, nanostructured microparticles (PLGA/ PEG NM) as a drug-delivery vehicle. The PLGA/PEG NM herein retain nanofibrous structures within microparticles, and possess a seven-fold increase in specific surface area than conventional spherical microparticles, allowing for synergistic improvement of a mucoadhesive property. In vivo evaluations demonstrated that PLGA/PEG NM showed prolonged retention in the gastrointestinal tract, as compared to control microparticles. When PLGA/PEG NM was loaded with losartan, an oral anti-hypertension drug, drug’s bioavailability increased by two-fold in comparison to a bolus losartan solution. Therefore, the PLGA/PEG NM are a promising carrier for oral drug delivery.
박천권,최가람,김영국,박기호,KIMSUNGWAN,최영빈 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.39 No.-
We developed a mathematical model to elucidate the absorption profile of an ocular drug, brimonidine,into the aqueous humour (AH) after its topical administration to the eye via microparticle formulations. For this, a compartment model with three distinct compartments of tear, cornea, and AH was proposed. The parameters were estimated, employing the experimental data of in vitro drug release, in vivopreocular retention, and drug concentration in the AH, which were obtained with four distinctmicroparticle types: (1) spherical microparticles without mucoadhesion, (2) spherical microparticleswith mucoadhesion, (3) nanostructured microparticles without mucoadhesion, and (4) nanostructuredmicroparticles with mucoadhesion. Our results showed that, for all microparticle types, the simulatedand experimental profiles of drug concentration in the AH were in good agreement, as were the overallpharmacokinetic parameters, implying that the model is reliable. With this validated model, wepredicted the drug concentration profile in the tear, where nanostructured, mucoadhesive microparticlesshowed greater than 1.9-fold increase in drug bioavailability, compared with the other microparticletypes. This improvement at the preocular surface was reflected in the enhanced drug bioavailability inthe AH: greater than 1.5-fold increase compared with the other microparticle types.
Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug
박천권,최영빈,김명훈,박민,이지은,이승호,박정환,윤경환 한국고분자학회 2011 Macromolecular Research Vol.19 No.11
In this study, we developed an esophageal stent capable of sustained delivery of an anticancer drug, fluorouracil (5-FU). The stents were coated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanofibers (DPN)via the electrospinning method, which exhibited a sustained drug release for up to 6 days. To prolong drug release,we also added the nanofiber layers composed of PLGA alone (PN), surrounding the DPN layer, as a more resistive diffusion barrier, where a period of drug release could be extended to 21 days with the DPN layer topped with another 192 μm thick PN layer. Therefore, we envisioned longer period of drug release with the thicker PN layers,obtained simply with a longer collection time of PLGA nanofibers via electrospinning. Overall, we concluded that the drug-delivery esophageal stent prepared in this study is promising in the long-term treatment of dysphagia caused by esophageal cancer.