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항당뇨약 Rosiglitazone의 혈관 수축성에 대한 이중성 조절
박진건,제현동,Park, Jin-Gun,Je, Hyun-Dong 대한약학회 2007 약학회지 Vol.51 No.5
Rosiglitazone ($Avandia^{(R)}$) represents a new class of antidiabetic drugs which are $PPAR{\gamma}$ agonists. The present study was undertaken to determine whether the new antidiabetic rosiglitazone influences on the agonist-induced regulation of vascular smooth muscle contraction as an antihypertensive and, if so, to investigate the related mechanism. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Rosiglitazone decreased Rho-kinase activating agonist (NaF or thromboxane $A_2$ mimetic)-induced contraction but not depolarization- or phorbol ester-induced contraction. Surprisingly, it slightly potentiated the latter contraction possibly opening a voltage-dependent calcium channel by its chemical structure on 50 mM KCI- or $1{\mu}M$ phorbol 12,13-dibutyrate-induced vasoconstriction. In conclusion, this study provides the evidence and possible related mechanism concerning the biphasic effect of an antidiabetic rosiglitazone as a possible antihypertensive on the agonistinduced contraction in rat aortic rings regardless of endothelial function.
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박진건(Jin Keon Park),홍민하(Minha Hong),이연정(Yeon Jung Lee),한주희(Juhee Han),황보람(Ram Hwangbo),반건호(Geon Ho Bahn) 대한사회정신의학회 2015 사회정신의학 Vol.20 No.2
본 연구는 아스퍼거 장애의 조기 진단을 위한 임상적 단서를 확인하고자 시행되었다. 1998년부터 2013년까지 일 대학 병원에서 아스퍼거 장애로 확진된 환자 31명의 병록지를 후향적으로 검토하여 사회인구학적 및 임상적 특성을 분석하였다. 병원에 방문하는 가장 많은 이유는 또래 관계 형성의 어려움이었다. 신경학적 결손에 대한 평가를 위해 VIQ와 PIQ의 차이의 절대값과 뇌파검사 자료를 검토하였다. VIQ와 PIQ 검사를 시행한 29명 중 15명이 15점 이상의 차이를 보였고, 뇌파를 시행한 17명 중 8명이 국소적 간질파 소견을 보였다. 전체 집단 자료 분석 후 최초 병원 방문 시 연령에 따라 13세를 기준으로 두 집단으로 나누어 집단간 비교하였다. 13세를 집단 분류 기준으로 채택한 이유는 기존 아스퍼거 장애 연구에서 거의 대부분의 아스퍼거 환자들이 13세 이전에 진단을 받았다는 점과, 우리나라 학제 상 초등학교에서 중학교로 진학하면서 적응상의 문제가 확대될 수 있는 연령이기 때문이다. 13세 이상 집단에서 공존 장애 숫자가 더 많았다(p=0.036). 주의력결핍/과잉행동장애가 가장 많은 공존질환이었으며, 가장 많이 사용되고 있는 약물은 항우울 제였다(p=0.025). 따라서 임상가들은 소아 및 성인 환자에서 흔히 나타나는 또래 관계 또는 대인 관계 어려움이 아스퍼거 장애의 중요한 단서임을 기억해야 할 필요가 있으며, 아스퍼거 장애 환자 진료시 신경학적 이상에 대한 평가를 고려해야 할 것이다. We investigated clinical clues retrospectively that would be valuable for the early diagnosis of Asperger syndrome. Subjects were 31 patients, mean age 14.3±6.6 years old on the first visit, at one university hospital from 1998 to 2013. The main reason of the hospital visit was the difficulty in peer relationship. As indirect methods to investigate the neurologic deficits, we checked the absolute value of the difference between verbal and performance IQ and the epileptiform discharge of the electroencephalograpy (EEG). 51.7% showed higher than 15 of the absolute value of IQ difference. Among 17 patients who had taken EEG, eight (47.0%) subjects revealed focal epileptiform discharge. After the analysis of whole subjects, we divided the subjects into two groups by the age of 13 on the first visit. The older than 13 years old group revealed significantly more comorbidities (p=0.036) and used more antidepressants (p=0.025) than the younger ones. Attention deficit/hyperactivity disorder was the most common comorbidity in both groups. These results suggest that health professionals have to keep in mind that peer relationship issue is one of the critical clues in order to not miss Asperger syndrome for young kids and adolescents. Thorough status checkup including neurophysiologic examinations should be considered for individuals with developmental delay.
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박진건・염경민・변아영・정유정・유성환 가톨릭관동대학교 대원환경연구소 2016 보건환경연구논문집 Vol.21 No.-
ABSTRACT : EM is abbreviation of Effective Microoganisms that are beneficial to humans combined and cultured cells. In this study, whether cultivation for several days is most effective, it is possible to know whether the purification is enough for use in edible crops. In addition, observing the difference in the growth rate between 'plants that have been treated with tap water' and 'plants that have been treated with waste water purified with EM', the positive effects of EM on plants it can prove business possibilities.
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Rosiglitazone의 이중성 혈관 수축 조절과 관련된 신호전달 기전
박진건 ( Jin Gun Park ),제현동 ( Hyun Dong Je ) 대구가톨릭대학교 자연과학연구소 2007 자연과학연구논문집 Vol.5 No.1
The present study was undertaken to determine whether the new antidiabetic rosiglitazone influences on the agonist-induced regulation of vascular smooth muscle contraction as an antihypertensive and, if so, to investigate the related mechanism. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Rosiglitazone slightly potentiated KCl or PDBu-induced contraction. Main mechanism of KCl- or PDBu-induced vasoconstriction is related with activation of voltage-dependent calcium channel or protein kinase C. On the contrary, rosiglitazone significantly decreased the magnitude of NaF-induced contraction. Effects of rosiglitazone on agonists-induced phosphorylation of MYPT1 at the newly-highlightened site of Thr855 by rho-kinase activation were determinded homogenizing aortic tissue and using immunoblotting. Rosiglitazone decreased NaF- or PDBu-induced phosphorylation of MYPT1(Thr855). These results indicate that inhibition of Rho-kinaseis the common pathway either in relaxation or loss of relaxation suggesting other related pathway such as protonation of amine group near pyridine potentiated depolarization eliminating relaxation effect of rosiglitazone in CKl- or PDBu-induced vasoconstriction. In conclusion, this study provides the evidence and possible related mechanism concerning the biphasic effect of an antidiabetic rosiglitazone as a possible antihypertensive on the agonist-induced contraction in rat aortic rings regardless of endotheliasl function.
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박용호,박진건,염만오 慶南大學校 附設 工業技術硏究所 1994 硏究論文集 Vol.12 No.-
본 연구는 국산화정책의 일환으로 개발된 유체커플링 및 기존커플링(수입품)의 성능을 측정할 수 있는 실험장치를 제작하고 실험데이타를 저장 및 활용할 수 있는 소프트를 개발하여 실험결과를 저장하며 필요에 따라 실험결과를 활용하여 유체커플링의 사용시에 예상되는 문제점을 해결하고 성능개선을 위한 자료를 제공하는데 그 목적을 둔다. 본 연구의 결과는 예상되는 변속유체커플링 및 토크컨버터의 국산화개발에도 응용 가능한 기초적 자료가 되리라 생각한다. The purpose of this research is to construct the experimental test set-ups and establish a series of performance test program for the domestically developed fluid couplings, and to provide a software to store and utilize these experimental data which can be used to improve the performance of the fluid coupling and solve on the job problems confronted in operation. The result of this study can contribute valuable references to the developement of variable speed fluid coupling and torque converter currently pursued by the domestic industry.
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