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인슐린 농도 변화에 따른 인슐린 내재화 ( Internalization ) 와 Degradation 의 변화
박원근(Won Kun Park),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jung),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A This study was conducted to investigate the effect of ambient concentration of insulin on insulin internalization and degradation in human erythrocytes. The absolute amount of internalized insulin was quantitated by multiplying the concentration of insulin by the percent specifically bound and internalized (by acid extraction method, PBS, pH 5.7) at the various insulin concentration (1.4, 2.5, 12.4, 112.4 ng/m1). The insulin degradation products (IDP) was assayed by using Sephadex G-50 column, HPLC with radioisotope detector in human erythrocytes which were incubated (37℃) at the various insulin concentration (1.43, 2.76, 14.76, 26.60ng/ml). Insulin internalization (ng/ml) increased in human erythrocytes with increasing concentration of insulin (3hr incubation time, 0.336 at 1.4, 0.275, at 2,5, 3.844 at 12.4, and 24.728ng/ml at 112.4ng/ml, 4hr incubation time, 0. 476, at 1.4, 0.925 at 2.5, 4.712 at 12.4 and 38.216ng/ml at 112.4ng/ml). Insulin degradation products (%) increased (2hr incubation time, 20.9 at 1,43; 38.0 at 2.76 and 38.0% at 14.76ng/ml) but no more than at a level of insulin concentration (2.76ng/ml) in normal human erythrocytes. In diabetic human erythrocytes, insulin degradation products (%) also increased (3br incubation time, 14.1 at 1.43, 19.0 at 2,76, 23.0 at 14.76, and 23.2% at 26.60ng/ml, 4hr incubation time, 39.4 at 1.43, 46.9 at ~2.76, 52. S at 14.76 and 53.0% at 26.60ng/ml) but no more than at a level of insulin concentration (14.76ng/ml), This result indicated that the ambient concentration of insulin may play an important role in the regulation of intracellular processing of insulin.
Chlamydomonas reinhardtii 엽록체 DNA 의 Methylation 에 미치는 Polyamine 의 영향
박원근(Won Kun Park),김재윤(Jae Yoon Kim),이순희(Sun Hi Lee),강빈구(Bin G . Kang),이강오(Kang Oh Lee) 한국식물학회 1991 Journal of Plant Biology Vol.34 No.4
Polyamine levels in the male and female cells as well as DNA methyltransferase activity in the female cells during gametogenesis of Chlamydomonas reinhardtii indicated that both spermidine and spermine levels were decreased while DNA methyltransferase activity was markedly increased about 12 hours after the onset of gametogenesis. In vitro, putrescine and spermine at 1 mM inhibited methylation of chloroplast DNA isolated from vegetative female cells by 35% and 65%, respectively. Spermine was found to be more inhibitory than putrescine at all concentrations tested. The pattern of the inhibition by polyamines appeared different from that caused by cations. The results obtained in this work suggest that the polyamine inhibition of DNA methylation is due to an action of polyamines on the enzyme involved instead of on the DNA itself.
Type 2 DM 환자에서 인슐린 또는 경구혈당강하제등의 치료에 의한 인슐린 내지환와 Dagradation 장애의 회복
박원근(Won Kun Park),고완(Wang Ko),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jeng),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.4
N/A The internalization of I-insulin in human erythrocytes was studied using an acid extraction technique (pH 5.7, PBS) from 7 patients with type 11 diabetes mellitus (DM) and 14 normal subjects before and after glucose control. Insulin degradation products from 4 patients with type 11 DM and 14 normal subjects in the same period were assayed using HPLC with Sephadex G-50 column and a radioisotope detector. The maximal rates of insulin internalization (Incubation time: 4 hours, at 37°C) which were decreased before glucose control (50.25±6.99%vs 80.23±7.73%), returned toward normal levels after glucose control (89.5±5.45%). The maximal degradation products of insulin (incubation time: 4 hours, at 37°C) which were decreased before glucose control (62.25±10.50vs 87.75±6.66%), returned toward normal levels after glucose control (91.4±7.60%). These results suggest that in type 11 DM, the decreased rate of insulin internalization and degradation may be one of the contributory factors in the pathogenesis of postbinding resistance, which is reversible with insulin or sulfonylurea treatment.
NIDDM 환자에서 혈당조절 전후의 Nitrogen Balance 와 IGF - I 변화에 관한 연구
최웅환(Woong Hwan Choi),박원근(Won Kun Park),신현호(Hyun Ho Shin),한인권(In Kwon Han),김은주,김선우(Sun Woo Kim),최영길(Young Kil Choi) 대한내과학회 1987 대한내과학회지 Vol.34 No.1
N/A We studied the effect of blood sugar control in patients with NIDDM on the IGF-I level and nitrogen balance as a metabolic index. The result as follows 1) There was no difference in IGF-I level between patients with NIDDM and normal control group. (222±60ng/ml vs 221±49ng/ml, p>0.1) 2) There was a statistically significant increment in IGF-I level in the NIDDM patients who improved to positive nitrogen balance from negative nitrogen balance. (217±55ng/ml vs 285±44ng/ml, p<0.05) 3) IGF-I level was not increased in patients who did not improve to positive nitrogen balance after suger control and the patient who was prositive nitrogen blance initially. (231±63ng/m1 vs 190±52ng/ml, p>0.1) 4) IGF-I level was not increased in spite of improved nitrogen balance after sugar control in patients with under body weight. (221±68ng/ml vs 213±42ng/ml, p>0.1) These reult sugested that mornitoring of serum IGF-I level in NIDDM patients is useful marker which represent metabolic compensation with treatment of diabetes.
Type 2 DM 환자에서 적혈구를 이용한 인슐린 내재화율과 Degradation Products 에 관한 연구
최웅환(Woong Hwan Choi),박원근(Won Kun Park),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jung),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A We studied insulin internalization and degradation at 37℃ in human erythrocytes from patients with type II DM and normal subjects. The internalization of 125I-Insulin in human erythrocytes was studied by using an acid extraction technique (pH 5.7, PBS) from 54 patients with type II DM and 14 normal subjects. Insulin degradation products was assayed with using Sephadex G-50 column, HPLC with radioisotope detector from 4 patients with type II DM and 14 normal subjects. The maximal rate of insulin internalization (Incubation time: 4hours, at 37℃) was decreased in patients with type II DM [51.40±14.67% (±SD) VS 80.23±7.73 % (±SD). P<0.001]. The maximal degradation products of insulin (Incubation time: 4hours, at 37℃) was decreased in patients with type II DM [62.50±10.50% (±SD) VS 87.75±6.66% (SD). p<0.001]. In conclusion, insulin internalization and degradation in human eryhrocytes from patients with type II DM are significantly reduced. These defect may be related to the cellular insulin resistance present in these patients.
잠재성 유두상 갑상선암에서 원발종양의 크기에 따른 공격성 정도 분석
박해린(Hai-Lin Park),곽진영(Jin Young Kwak),강석선(Seok Seon Kang),김도연(Do Youn Kim),강형곤(Hyung Gon Kang),심정연(Jung Yeon Shim),김유리(Yoori Kim),박원근(Won Kun Park),최영길(Young Gil Choi) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.6
Purpose: Occult papillary thyroid carcinomas (OPC) are defined as tumors measuring <15 ㎜. These tumors are believed to be a less aggressive subset of papillary cancers. They generally behave more like benign lesions and are often more conservatively treated. However, it is unclear if a cancer 1.0 to 1.5 ㎝ in diameter will have a similar favorable clinical behavior as tumors <1.0 ㎝ (micropapillary thyroid carcinoma). Therefore, a retrospective chart review study of patients with OPC in order was carried out in order to answer this question and characterize the biology and optimal treatment for OPCs. Methods: From October 2001 to January 2007, Among the impalpable thyroid nodules detected incidentally during screening examinations, 260 patients underwent surgery for occult papillary thyroid cancer (OPC) at Kangnam Cha University hospital. The data from these patients was analyzed retrospectively. The mean follow up period was 25.6 ± 14.5 (max:63, min:1) months. Results: The mean age of these patients was 42.8 years, and 233 (89.5%) were female. 46.2% of patients underwent a total or neartotal thyroidectomy, and 54.6% underwent a central lymph node dissection. Of the 260 patients, 55 (21.2%) had lymph node metastases. The OPC presented with signs of aggressiveness including multifocality (34.2%), bilaterality (17.7%), capsular invasion (52.7%), and lymph node metastases (21.2%). A progressively increasing frequency of the signs of tumor aggressiveness was observed with increasing tumor size at presentation. LN metastases were associated with the tumor size (P=0.0063), extracapsular invasion (P=0.0015) and multfocallity (P=0.0020). However, there was no association with age and gender. With a follow-up of up to 63 months, 3 patients had a local recurrence (0.014%). No patients currently have active disease and no patients with OPC died during this period. Conclusion: In OPC patients, there is a progressively increasing frequency of the signs of tumor aggressiveness with increasing tumor size. Moreover, a small size itself cannot guarantee low risk and low recurrence rate. The prevalence of LN metastases and extracapsular invasion were higher in those with a tumor size >0.5 ㎝. A near-total or total thyroidectomy with a central lymph node dissection is the preferred treatment. The early detection and treatment of OPC might be warranted through the routine use of thyroid USG and USG-guided FNA.