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아지도싸이미딘의 지속성방출형담체로서의 소수성시클로덱스트린유도체
박기배,이광표,서보연 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2
This study has been undertaken to evaluate hydrophobic cyclodextrin(CD) derivatives as a sustained release carrier of azidothymidine(AZT). AZT. which has potent activity against AIDS and AIDS-related complex as thymidine analogue, has been reported that it has significant toxicity and short half life. Therefore, it is necessary to design sustained release oral dosage form to avoid undesirable side effects attributable to an excessive plasma concentration and to reduce the frequency of administration of AZT. Inclusion complexes of AZT with acetyl-β-cyclodextrin (ACβCD) and triacetyl-β-cyclodextrin(TAβCD) were prepared by solvent evaporation methcd. Interactions of AZT with CD were investigated by Differential Scanning Calorimetry(DSC) and Infrared Spectrophotometry(IR). The decreasing order of water solubilities of AZT and AZT-CD inclusion complexes were as follows: AZT (27.873±0.015,㎎/㎖)) AZT-ACβCD (3.377±0.03) > AZT-TAβCD (2.528±0.001). Partition coefficients of AZT-ACβCD and AZT-TAβCD inclusion complexes were increased by 1.27-fold. 1.54-fold in pH 1.2 and 1.32-fold. 1.47-fold in pH 6.8 in comparison with that of AZT. The mean dissolution time (MDT, min) which represents the rapidity of dissolution rate of AZT, AZT-ACβCD. AZT-TAβCD were 5.12. 14.02 and 19.38 min in PH 1.2 and 2.52, 15.19 and 18.19 min in pH 6.8. AZT was very rapidly and completely dissolved in pH 1.2 and pH 6.8 within 5 minutes. But AZT-CD inclusion complexes showed the sustained release pattern in comparison with AZT alone. The simultaneous in situ nasal and jejunal recirculation study to compare the intrinsic absorptivity and the property of absorption sites revealed that the absorption of AZT-TAβCD (N:35.35±1.08% J:27.47±1.18% was more than that of AZT (N: 16.89±2.25%. J:15.86±2.33%. The above results suggest that TAβCD which is a hydrophobic cyclodextrin may serve as sustained release carrier with absorption enhancing effect.
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시클로덱스트린과의 포접에 의한 케토고나졸의 비점막 흡수증가
박기배,이광표,노현구,안홍직,서보연,온윤성 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.2
Inclusion complexes of ketoconazole(KT) with α^-, β^- cyclodextrin(CD) and dimethyl-β-cyclodextrin (CD) and dimethyl-β-cyclodextrin(DMβCD) as nasal absorption enhancer were prepared in 1:2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability(P_(app) : ㎝/sec × 10^(-5)±S.E.), corrected by surface area of absorption, was 5.10±0.3(N, KT-DMβCD) >4.13±0.4(N, KT-β-CD) >3.52±0.2(N, KT-α-CD) >2.76±0.3(J, KT-DMβCD) >2.61±0.5(J, KT-β-CD) >2.42±0.4(J, KT-α-CD) at pH 4.0. The in crease in permeability of KT-DMβCD inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of KT-DMβCD inclusion complex after nasal administration was more rapid than those of ketoconazole alone and KT-DMβCD inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal KT-DMβCD inclusion complex in rats. The present results suggest that KT-DMβCD inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.
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박기배,김영화,이용석,이광표 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.4
The absorption characteristics of itraconazole, which is an antifungal agent, from intestinal segments in the anesthetized rat in situ were investigated in order to design an effective oral drug delivery system. The pH-solubility profile of itraconazole, the rate and extent of absorption of itraconazole, the optimal absorption site(s) of itraconazole and the absorption enhancing effect of sodium cholate on itraconazole were examined in the present study. In situ single-pass perfusion method and recirculating perfusion technique using duodenum(D), jejunum(J) and ileum(I) were employed for the calculation of apparent permeability(Pe) and apparent first-order rate constant(Kobs), respectively. The results of this study were as follows: (1) Itraconazole showed appreciable aqueous solubility only at pH values of below 2.0. (2) pe(㎝/sec) decreased in the following order: D(10.24±1.78×10⁴)>J(8.86±0.79×10⁴)>I(3.78±0.13×10⁴). (3)Kobs(min⁴) decreased in the following order J(17.12±3.19×10³)>D(13.37±0.6×10⁴)>I(1.05±0.91×10³). (4) The solubility of itraconax makedlv increased with the increase of the concentration of sodium cholate. (5) The addition of 10 mM sodium cholate significantly mereased the apparent first-order rate constant of itraconazole in the ileum by a factor of 6.8.
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박기배,이광표,정의차,조정기 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1
This study was carried out for the purpose of developing an effective temazepam soft elastic gelatin capsule (softgel) which exhibits an excellent bioavailability and of comparing the rate and extent of absorption of temazepam from the marked elixir and prepared softgel using hydrophilic liquid such as polyethylene glycol 400 as a suspending agent by rotary die method. Both softgel and elixir containing 3 mg of temazepam were given to 7 healthy male New Zealand White rabbits in a single oral dose cross-over study. Plasma temazepam concentrations were measured by HPLC. The mean peak concentrations of temazepam following a single oral dosing as softgel and elixir dosage form were 13.84 and 13.25 ng/㎖, respectively. And the mean time to peak concentration was 1.29 hr for the softgel and 1.07 hr for the elixir. There was no significant difference in the extent of drug absorption (AUC) for the two different dosage froms (p>0.05). While the softgel exhibited mean lag time of 0.63 hr, the elixir did not show any lag time. Statistical moment parameters such as the mean residence time and variance of the mean residence time did not differ significantly for the two formulations.
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