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朴祺培 안성산업대학교 1984 論文集 Vol.16 No.-
植物生長調節劑를 철쭉의 揷木時 處理하였을 때 根重量, 發根長, 發根數에 미치는 影響을 究明하기 위하여 試驗한 結果를 要約하면 다음과 같다. 1. NAA의 處理에서는 50ppm이 가장 좋았다. 2. IAA의 處理에서도 50ppm이 가장 좋았다. 3. Sugar의 處理에서는 5%의 處理가 가장 좋았다. 4. Sugar 5% 處理가 NAA나 IAA 50ppm의 處理보다 效果가 좋았다. This experiments were carried out to find when Rhododendron Caucasium PALLAS Root cutting which the effect with some plant regulators on the results of root weight, root length, number of rooting. The results are follows. 1. The treatment of NAA 50ppm was the best result. 2. The treatment of IAA 50ppm was the best result. 3. The treatment of 5 percent sugar was the best result than other treatment. 4. The treatment of 5 percent sugar liquid was more plomote and NAA and IAA 50ppm treatment.
랫트에 있어서 시프로플록사신의 흡수와 생체이용율에 미치는 돔페리돈 , 스코폴라민부틸브로마이드 및 시메티딘의 영향
박기배,이광표,임혜숙,이도익 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2
The effects of domperidone, scopolamine butylbromide and cimetidine on the absorption and bioavailability of ciprofloxacin were studied in female rats. Ciprofloxacin was given in a single oral dose of 30 ㎎/㎏ to control group. Ciprofloxacin was concurrently administered with domperidone (T₁ group), scopolamine butylbromide (T₂ group), and cimetidine (T₃ group) to rats, respectively. Significantly changed pharmacokinetic parameters observed in T₂ group when compared with control group were first-order absorption rate constant, Ka(4.43±0.85 versus 2.86±0.41 hr^(-1), p<0.05), time needed to reach peak concentration, T_(max) (32.27±2.46 versus 51.75±5.51 min, p<0.05), area under the plasma concentration-time curve, AUC (332±19 versus 477±27 ㎍·min/㎖, p<0.05) and absolute bioavailability, Fabs (60.6±3.6 versus 87.0±5.0%, p<0.05). On the other hand, domperidone and cimetidine did not significantly affect the absorption of ciprofloxacin. It is suggested that when scopolamine butylbromide is selected for clinical use, there is need for awareness of the reduction in absorption rate and the enhancement in absorption extent of ciprofloxacin.
시클로덱스트린과의 포접에 의한 케토고나졸의 비점막 흡수증가
박기배,이광표,노현구,안홍직,서보연,온윤성 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.2
Inclusion complexes of ketoconazole(KT) with α^-, β^- cyclodextrin(CD) and dimethyl-β-cyclodextrin (CD) and dimethyl-β-cyclodextrin(DMβCD) as nasal absorption enhancer were prepared in 1:2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability(P_(app) : ㎝/sec × 10^(-5)±S.E.), corrected by surface area of absorption, was 5.10±0.3(N, KT-DMβCD) >4.13±0.4(N, KT-β-CD) >3.52±0.2(N, KT-α-CD) >2.76±0.3(J, KT-DMβCD) >2.61±0.5(J, KT-β-CD) >2.42±0.4(J, KT-α-CD) at pH 4.0. The in crease in permeability of KT-DMβCD inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of KT-DMβCD inclusion complex after nasal administration was more rapid than those of ketoconazole alone and KT-DMβCD inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal KT-DMβCD inclusion complex in rats. The present results suggest that KT-DMβCD inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.
박기배,이광표,정의차,조정기 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1
This study was carried out for the purpose of developing an effective temazepam soft elastic gelatin capsule (softgel) which exhibits an excellent bioavailability and of comparing the rate and extent of absorption of temazepam from the marked elixir and prepared softgel using hydrophilic liquid such as polyethylene glycol 400 as a suspending agent by rotary die method. Both softgel and elixir containing 3 mg of temazepam were given to 7 healthy male New Zealand White rabbits in a single oral dose cross-over study. Plasma temazepam concentrations were measured by HPLC. The mean peak concentrations of temazepam following a single oral dosing as softgel and elixir dosage form were 13.84 and 13.25 ng/㎖, respectively. And the mean time to peak concentration was 1.29 hr for the softgel and 1.07 hr for the elixir. There was no significant difference in the extent of drug absorption (AUC) for the two different dosage froms (p>0.05). While the softgel exhibited mean lag time of 0.63 hr, the elixir did not show any lag time. Statistical moment parameters such as the mean residence time and variance of the mean residence time did not differ significantly for the two formulations.
Studies on Synthesis, Hydrolysis and Oral Absorption of Piperacillin Phthalidyl Ester
박기배,최승호,최영욱,김종갑,Park, Gee-Bae,Choi, Seung-Ho,Choi, Young-Wook,Kim, Johng-Kap 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.3
Piperacillin phthalidyl ester was synthesized by reacting piperacillin with triethylamine and bromophthalide in acetone and its chemical structure was determined by UV, IR, and PMR. The partition coefficient of the ester was increased and the ester was more lipophilic and less water soluble than piperacillin. The ester did not show the antimicrobial activity against Bacillus subtilis ATCC 6633 in vitro, but when hydrolyzed, the parent drug of ester, piperacillin, revealed antimicrobial activity in vivo. After a single oral dose of both piperacillin and the ester to rabbits, the serum piperacillin concentration was measured by bioassay. The ester exhibited improved pharmatokinetic characteristics: $T_{max}\;of\;2hr,\;C_{max}\;of\;4.26{\mu}g{\cdot}ml^{-1},K_{el}\;of\;0.057hr^{-1},\;and\;total\;AUC\;of\;85.42{\mu}g{\cdot}hr{\cdot}ml^{-1}$. Piperacillin on the other hand, did not exhibit any gastro-intestinal absorption.