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난알부민으로 알레르기 비염이 유발된 마우스에서 형개의 개선효과
송대욱 ( Dea Uk Song ),허준 ( Jun Heo ),이성엽 ( Sungyub Lee ),김재현 ( Jae Hyun Kim ),이비나 ( Bina Lee ),민주희 ( Ju Hee Min ),김은영 ( Eun Young Kim ),손영주 ( Youngjoo Sohn ),정혁상 ( Hyuk Sang Jung ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.6
Objectives : The aim of this study was to evaluate the effect of Schizonepeta Spica water extract (SS) on the OVA-induced BLAB/c mice allergic rhinitis model. Methods : Thirty two BALB/c mice were equally assigned to 4 groups; the sham group, the control group, the cetirizine hydrochloride (Cet) treatment group, and the SS treatment group. Sham group was sensitized and challenged with saline, and the other groups were sensitized and challenged with OVA. The dosage of SS was 7.6 mg /kg·day, and Cet was 10 mg/kg·day. Nasal rubbing and sneezing were measured by the behavior observation. The concentrations of IL-1β, IL-10, TNF-α and MIP-2 in the sera of allergic rhinitis model were measured by mouse cytokine/chemokine magnetic bead panel kits. Total IgE and OVA-specific IgE were measured by ELISA method. Epithelial thickness and eosinophil infiltration of nasal septum was investigated by histological examination. Results : The clinical symptoms that increased in control group were significantly reduced in SS-treated group. Serum total IgE and OVA-specific IgE in the SS-treated group were significantly reduced compared to the control group. The concentration of IL-1β, IL-10, TNF-α and MIP-2 in SS-treated group showed a significant reduction compared to the control group. The infiltration of eosinophil into nasal tissues of SS-treated group decreased markedly compared to control group, and thickness of nasal septum in nasal mucosa showed a significant reduction compared to control group. Conclusions : According to the above result, it is suggested that SS may inhibit the early and late phase of allergic rhinitis reaction.