An overview of herbal medicine for atopic dermatitis

이향숙,Lee, Hyang-Sook The Korean Medicine Society for the Herbal Formula 2009 대한한의학 방제학회지 Vol.17 No.2

목 적 : 한약 또는 한약제제의 아토피성 피부염에 대한 치료효과를 조사하고 향후 연구방향을 제시하기 위하여 고찰연구를 시행하였다. 방 법 : PubMed에 한약과 아토피성 피부염과 관련된 검색어의 조합을 넣어 포함기준에 맞는 무작위배정 대조군 임상연구만 포함하였다. 연구설계, 치료방법, 대조군, 평가지표, 결과, 부작용 관련 정보를 미리 정해놓은 자료 추출 형식에 맞추어 추출하고 방법론적 질 평가는 옥스포드 질 평가 척도와 그룹 할당 은닉(allocation concealment) 여부를 평가하였다. 연구들이 임상적 및 통계적으로 상이하여 메타분석은 이루어지지 않고 기술적 고찰만 실시하였다. 결 과 : 모두 8편의 연구가 고찰기준을 만족시켰다. 다양한 복합한약제제와 한약이 포함된 외용제가 평가되었는데 8편 가운데 5편에서 아토피성 피부염의 증상을 호전시키는 것으로 나타났다. 방법론적 질은 대체로 양호한 것으로 나타났으며 일부 효과적인 것으로 나타난 한약복합제제에서 간손상 등의 부작용도 보고되었다. 결 론 : 한약 또는 한약제제를 이용한 치료는 아토피성 피부염의 증상개선에 도움이 되는 것으로 보이나 현재 근거는 부족하다. 우리나라에서 많이 쓰이는 한약제제들 역시 엄정한 임상연구를 거쳐 그 효과를 평가하고 근거를 구축해야 할 것이다.

쥐의 뇌 시토졸 Aldehyde Dehydrogenase 의 정제 및 특성에 관한 연구

이향숙,주충노 ( Hyang Sook Lee,Chung No Joo ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.6

Rat brain cytosolic aldehyde dehydrogenase (ALDH, EC 1.2.1.3) was purified by ammonium sulfate precipitation, DEAF-Sephacel, Blue Sepharose CL-6B and 5`-AMP Sepharose 4B affinity chromatography. K_m values of the cytosolic ALDH for short chain aliphatic aldehyde and aromatic aldehyde were 10^(-3)M level and that for indole-3-acetaldehyde was 10^(-4)M level. However, this enzyme had a very low Km value (10^(-6) level) and the greatest affinity for succinic semialdehyde suggesting that the cytosolic ALDH seemed to be closely related to the metabolism of γ-aminobutyrate. K_m of this enzyme for NAD was 10^(-5)M level while that for NADP+ was 10^(-4) M level. It seemed that NAD+ might be mainly used as a cofactor of this enzyme. Rat brain cytosolic ALDH was sensitive to disulfiram and the enzyme activity decreased to about 50% in the presence of 10 μM disulfiram but 30% of the total activity of this enzyme remained even in the presence of 25 μM disulfiram. This enzyme had esterase activity as well. It was realized that iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5`-phosphate inhibited the enzyme activity suggesting that amino acid residues such as cys-teine, serine, lysine might participate at the active site of this enzyme.

쥐의 뇌 시토졸 Aldehyde Dehydrogenase의 정제 및 특성에 관한 연구

이향숙,주충노,Lee, Hyang-Sook,Joo, Chung-No 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.6

쥐의 뇌 시토졸 분획으로부터 aldehyde dehydrogenase(ALDH. EC 1.2.1.3)를 황산암모늄 분별침전, DEAE-Sephacel, Blue Sepharose CL-6B, 5'-AMP Sepharose 4B affinity chromatography 방법으로 분리 정제하였다. Short chain aliphatic aldehyde나 aromatic aldehyde에 대한 $K_m$값은 $10^{-3}M$ 수준이 었고 indole-3-acetaldehyde에 대 한 $K_m$값은 $10^{-4}M$ 수준이었으나, succinic semialdehyde에 대해서는 매우 낮은 $K_m$값($10^{-6}M$ 수준)을 나타내었으며 친화력도 가장 큰 것으로 보아 ${\gamma}-aminobutyrate$ 대사와 연관성이 큰 것으로 생각된다. $NAD^+$에 대한 $K_m$값($10^{-5}M$ 수준)은 $NADP^+$에 대한 $K_m$값($10^{-4}M$ 수준)의 1/10 정도이였으며 $NAD^+$가 주로 보조효소로 작용하는 것으로 생각된다. 이 효소의 disulfiram에 의한 억제현상은 disulfiram의 농도가 $10{\mu}M$일 때 효소활성이 약 15% 감소되었으나, disulfiram의 농도가 $25{\mu}M$로 증가하여도 약 30%의 효소활성은 남아있었다. 또한 이 효소는 dehydrogenase 활성외에 esterase 활성을 나타내었고 iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5'-phosphate 등에 의해 활성 이 억제 되는 것으로 보아 cysteine, serine, lysine같은 아미노산 잔기가 효소활성 부위에서 중요한 역할을 할 것으로 생각된다. Rat brain cytosolic aldehyde dehydrogenase (ALDH, EC 1.2.1.3) was purified by ammonium sulfate precipitation, DEAF-Sephacel, Blue Sepharose CL-6B and 5'-AMP Sepharose 4B affinity chromatography. $K_m$ values of the cytosolic ALDH for short chain aliphatic aldehyde and aromatic aldehyde were $10^{-3}M$ level and that for indole-3-acetaldehyde was $10^{-4}M$ level. However, this enzyme had a very low $K_m$ value ($10^{-6}$ level) and the greatest affinity for succinic semialdehyde suggesting that the cytosolic ALDH seemed to be closely related to the metabolism of ${\gamma}-aminobutyrate$. $K_m$ of this enzyme for NAD was $10^{-5}M$ level while that for $NADP^+$ was $10^{-4}M$ level. It seemed that $NAD^+$ might be mainly used as a cofactor of this enzyme. Rat brain cytosolic ALDH was sensitive to disulfiram and the enzyme activity decreased to about 50% in the presence of $10{\mu}M$ disulfiram but 30% of the total activity of this enzyme remained even in the presence of $25{\mu}M$ disulfiram. This enzyme had esterase activity as well. It was realized that iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5'-phosphate inhibited the enzyme activity suggesting that amino acid residues such as cys-teine, serine, lysine might participate at the active site of this enzyme.

초산(醋酸), 질산(窒酸), 인산(燐酸)을 함유한 삼원계(三元系) 폐혼산(廢混酸)으로부터 인산(燐酸) 회수(回收)에 관한 기초 연구(硏究)

이향숙,이창훈,신준영,김주엽,안재우,Lee, Hyang-Sook,Lee, Chang-Hoon,Shin, June-Young,Kim, Ju-Yup,Ahn, Jae-Woo 한국자원리싸이클링학회 2005 자원리싸이클링 Vol.14 No.5

Recovery of phosphoric acid from waste acid mixture of acetic, nitric and phosphoric acid has been attempted by using solvent extraction method. In this work, organic phosphate was used as an extraction agent. The effect of phosphate concentration, agitation speed and time on the solvent extraction of acetic and nitric acids has been investigated. The optimum concentration of phosphate for preferential extraction of acetic and nitric acids from waste acid was found to be about 50% irrespective of agitation speed and time. Purified phophoric acid was recovered from extraction residue at 1/3 of A/O ratio and 6th stage of extraction stage, which is well consistent with the value calculated by using McCabe-Thiele diagram.

개별 작업치료와 통합된 집단회상프로그램이 장기요양시설 노인의 심리적 건강과 인지기능에 미치는 효과

이향숙 ( Hyang Sook Lee ),윤정애 ( Joung Ae Yoon ),노종수 ( Jong Su Noh ),차정진 ( Jung Jin Cha ),강선애 ( Sun Ae Kang ),강현아 ( Hyun A Kang ),김은미 ( Eun Mi Kim ),박종현 ( Jong Hyun Park ),이보람 ( Bo Ram Lee ) 고령자·치매작업치료학회 2012 고령자.치매작업치료학회지 Vol.6 No.2

Purpose: This study aims to investigate the effect of individual occupational therapy and the integrated group reminiscence counseling on psychological health and cognitive function of the elderly at long-term care facilities, Methods :Among the elderly at long-term care facilities, each eight people were randomly selected as experimental and control groups, respectively. Individual occupational therapy and group remi?niscence counseling were given to experimental group for 30minutes once a week and 30-40 minutes twice a week (total 16 times) for 8 weeks, respectively. Pre-and post-tests were per?formed using KGDS and SF-8 for psychological health(depression and quality of life), MMSE-K and memory item of NCSE for cognitive function, respectively. Wilcoxon sign?ed-ranks tests was used to examine the difference before and after the intervention in two groups, respectively. Mann-Whitney test was used to examine the difference in changes be?tween two groups after the intervention, Results: Experimental group sh wed statistically significant difference in depression and quality of life which were psychological health after intervention, but control group showed no statistically significant difference. Changes of MMSE-K after the intervention between two groups showed statistically significant difference, Conclusion: Individual occupational therapy and group reminiscence counseling gave the positive impact on psychological health and changes in cognitive function of the elderly at care facilities. Therefore, I would like to propose the development of individual occupational therapy and in?tegrated group reminiscence counseling as an effective method of occupational therapy.

한국 여고생의 사상체질과 자아정체감간의 관계

이향숙 ( Hyang Sook Lee ),김광웅 ( Kwang Woong Kim ) 대한아동복지학회 2005 아동복지연구 Vol.3 No.1

The purpose of this study is to find out whether there are some differences of ego-identity according to sasang constitutions based on 4 elements of Yang-in(the bright, active, and male principle of the universe standing for Sun) and Eum-in(the dark, inactive, and female principle of the universe standing for Moon). QSCCII+ and ego-identity test are given to 303 female high school students in Seoul and Daegu and then a multiple analysis is conducted in which 7 subordinate factors of ego-identity are dependent variables and 4 Sasang constitutions are independent variables. People who have Sasang constitutions, belonging to constitutions of Yang-in, are more likely to be self-accepting, self-asserting and self-respecting than people who have physical constitutions, belonging to constitutions of Eum-in. However, there are not much differences between people of both categories in the factors such as stability, goal-oriented personality, consciousness of self-originality, and will of playing roles in social relationships. Among 7 subordinate factors of ego-identity, self-acceptance and consciousness of self-respect can be different with Sasang constitutions(Taeumin, Soyangin, Soeumin), while stability, goal-oriented personality, consciousness of self-originality, and will of playing roles in social relationships have little difference between people of Yang-in and people of Eum-in. That is to say, in the factor of self-acceptance, there is no difference between Taeumin and Soyangin and between Taeumin and Soeumin. Soyangin are more likely to be self-accepting than Soeumin. In the factor of self-assertion, there is no difference between Taeumin and Soeumin. But Soyangin are more likely to be self-asserting than Taeumin and Soeumin. In the factor of consciousness of self-respect, there is no difference between Taeumin and Soeumin, while Soyangin are more likely to be more conscious of self-respect than Taeumin and Soeumin.

유아의 외현화 문제행동감소를 위한 통합치료 사례연구 -몬테소리교육과 집단치료놀이의 통합치료를 중심으로-

이향숙 ( Hyang Sook Lee ) 한국실천유아교육학회 2006 실천유아교육 Vol.11 No.-

차와 일상, 생활문화적 의미

이향숙 ( Lee Hyang-sook ),정승안 ( Jung Seung-an ) 동양사회사상학회 2020 사회사상과 문화 Vol.23 No.4

Recently, the academic community’s interest in everyday life soared. It’s time for everyday life to become a trend. Of the countless changes that Corona has brought, the most groundbreaking will be the change in the realm of life that surrounds our daily lives. What we want to consider here is a reflective view of tea and living culture. Interest in small but microscopic daily life, such as food, clothing and shelter, is the work of looking back on our daily lives and living worlds from a reflective point of view. This is part of the practical work of preparing for the post-Corona era. Living slowly in a rapidly changing modern society is a resistance to the entire modern society centered on fast food. Therefore, the living and cultural views surrounding Tea, which reveal the social trend of the Slow Food movement in the living culture, can be given sufficient significance. Today we note the negative effects of drinking from the abolition of everyday alcohol. Drinking has side effects that seriously break down the existing social hierarchy and order. However, Teas are an important medium that can go beyond these abuses. Exchanges with transcendental objects in drunken irrational states are impossible in everyday communication, but entry into this state is possible only with Tea and simple meditation. Here we took a look at the four aspects of this Tea’s life and cultural functions. 1)The means of performance 2) The means of health 3) the ritual, the means of consciousness 4) the cultural products and the functions as an experience tourism product. This functional meaning confirms that the Tea performs a reflective function in everyday culture.

경북지역 종가의 혼례문화 사례연구

이향숙 ( Hyang Sook Lee ),주영애 ( Young Ae Ju ) 대한가정학회 2012 Human Ecology Research(HER) Vol.50 No.6

This study surveyed features of weddings in the main family by selecting 10 families in which the grandnephew and grandnephew`s wife dwell in the head house, have a shrine, and hold a memorial service for Bulcheonwi (不遷位). A case survey through in-depth interview was carried out from April 9, to October 8, 2011. It surveyed the contents and the wedding artifacts in Uihon (議婚), Napchae (納采), Nappye (納幣), Daerye (大禮), Hyeongugorye (見舅姑禮), which are the procedures of traditional wedding that have been kept in the wedding ceremony of the main family. As a result, in deciding on marriage, the marriage was formed on the basis of similar Gagyeok (家格) and on ancestor`s common scholastic mantle or origin. As for wedding furnishings, wedding presents, and wedding gifts, 9 out of 10 families were indicated to give and take weakly. Also, 6 out of 10 families held a traditional wedding ceremony in the yard of the bride`s house. Hyeongugorye (見舅姑禮) was indicated to be held by all of the 10 families. A continuous effort in academic circles and industries is demanded for preserving the living culture of the main family, which proceeds with following the traditional elements even amid a rapidly-changing historical flow as today.

고구려(高句麗) 고분벽화(古墳壁畵)에 나타난 헤어스타일 분석(分析)과 일러스트레이션

이향숙 ( Hyang Sook Lee ),최근희 ( Keun Hee Choi ) 한국미용학회 2009 한국미용학회지 Vol.15 No.4

The hair style of women in the Goguryeo`s ancient tomb paintings can be said as the root of Korean ancient hair style. It is also the root of beauty art. But, because of its unclear contour and colour, it is very hard to understand its substance. The reason why it is reproduced with the illustration rather than the spatial reproduction is to express such vague part more concretely by using the data. Before entering the illustration, the hair style to reproduce should be selected first. As the Goguryeo`s ancient tomb paintings are on the wall of tombs, there should be paintings which have some discernable contours at least. Even though this condition is satisfied, there are wall paintings which lack the meaning of reproduction in view point of reproduction of ancient hair style. The hair styles for the illustration were selected from these tombs. They are 8 kinds in total: hiljagye, top hair, loosen gimyeong hair, chignon hair, hanged goek, tied jungbal hair, hwangye, and jiknyeo hair. In the illustration, any presumption is possible. But in the approach through the data application, the maximum restraints are imposed on it. The illustration work for the reproduction of Goguryeo women`s hair style was the one that provided the possibility and the limit at the same time. This work will be helpful in any ways for the future reproduction of Goguryeo women`s life style.