임신가토에 있어 Oxytetracycline의 흡수와 배설에 관한 연구

김현중(HJ Kim),이철진(CJ Lee),문호길(HG Moon),임광호(KH Lim) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.1

약물의 생체내 이용 효율에 관한 연구로 Oxytetracycline의 흡수와 배설을 매시간당 6회에 걸쳐 측정하여 임신가토, 비임신 가토 및 웅성 가토와 비교 관찰하였다. 1. 임신 초기 자성, 가토군, 임신말기 자성 가토군, 비임신 자성 가토군 및 웅성 가토군에서 흡수된 Oxytetracycline의 혈중 농도는 2시간째에 최고농도에 이르게 되는데, 이때의 혈중농도는 각각 28.0 mcg/ml, 24.0 mcg/ml, 33.0 mcg/ml 및 30.0 mcg/ml이다. 2. 임신 초기 자성 가토군, 임신말기 자성 가토군, 비임신 자성 가토군 및 웅성 가토군에서 흡수된 Oxytetracycline의 뇨 배설량은 역시 2시간째에 최고에 달하게 되는데 이때의 측정치는 각각 31.36 mcg/min, 26.64 mcg/min, 37.95 mch/min, 34.50mcg/min이다. 3. Oxytetracycline의 뇨중 청소율은 각군에서 1.04 ml/min내지 1.05 ml/min로서 별 변동이 없었다. The absorption and excretion of oxytetracycline in pregnant rabbit for drug availability were measured hourly at 6 times to compare with them in non-pregnant rabbit group and male rabbit group. 1) The blood levels of oxytetracycline in early pregnant rabbit group, late pregnant rabbit group, non-pregnant rabbit group and male rabbit group were respectively 28, mcg/ml, 24.0mcg/ml, 33.0mcg/ml and 30.0 mcg/ml at the second hour, which they were in peak. 2) The excretion of oxytetracycline in early pregnant rabbit group, late pregnant rabbit group, non-pregnant rabbit group and male rabbit group were respectively 31.36mcg/min, 26.64mcg/min, 37.95 mcg/min and 34.50 mcg/min at the second hour, which they were in peak. 3) The urinary clearance rates of oxytetracycline in blood were evenly unchangable in each groups in the range from 1.04 ml/min to 1.15 ml/min.

정상및 이상분만중의 혈장 beta-endorphin치의 변동에 관한 연구

김현중(HJ Kim) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.9

정상및 이상분만중의 혈장 beta-endorphin치의 변동에 관한 연구 The plasma β-endorphin levels were measured by radioimmunoassay after silicicacid plasma extraction in 10 women who had spintaneous labor at term in 7 who had submitted to emergency cesarean section, and in another 7 who had undergone elective cesarean section and in the umbilical cord of their newborns In cases of spontaneous labor there were progressive increase in β-endorphin concentrations as labor advanced the maximal values being observed immediately after delivery Their newborns`s cord plasma β-endorphin values were relatively higher than the maternal values without showing any correlations with them In the cases of emergency cesarean section the maternal plasma endormphin concentrations were significantly higher than those of the spomtaneous delivery cases and those who had undergone elective cesarean sections Their newborns` cord plasma β-endorphin concentrations with one-minute Apgar sxore less than 7 were significantly higher than those found in the newborn with Apgar score of 8 to 10 (P<0.01) In women who had undergone elective cesarean section the maternal β-endorphin concentrations were significantly olwer than those of the spomtaneous delivery cases or emergency cesarean section cases, and their neonatal endorphin levels were signigicantly higher than the maternal levels(P<0.05) The above data suggest that the elevated β-endorphin level found sfter vagianl delicvery could entirely be due to stress pain and probably the emotional shock accompanying the labor.

Clear Cell Carcinoma of Ovary의 1예

이철진(CJ Lee),김현중(HJ Kim),문호길(HG Moon),정종호(JH Chung) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.10

저자들은 초경이 없는 20세 여자에서 시험개복을 시행한후 조직학적으로 확진된 Clear Cell Carcinoma Of Ovary 의 1예를 보고하고 문헌을 고찰하였다. Clear Cell Carcinoma Of Ovary is a rare ovarian tumor. We had experienced one case of Clear Cell Carcinoma Of Ovary at the age of 20 year old woman. A brief review of the literature and discussion concering Clear Cell Carcinoma is presented.

개복수술의 임상적 고찰

문호길(HG Moon),김현중(HJ Kim),정혁(H Jung),황용우(YW Hwang) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.8

1975년 1월부터 1979년 12월까지의 5년간 조선대학교 의과대학 부속병원 산부인과에서 입원하여 개복수술을 받은 제왕절개술, 자궁외임신, 난소종양, 자궁근종, 자궁경부암, 골반강내 염증성질환 및 융모성질환의 연령적 분포, 병명별 분포, 수술명, 증상등을 분석하여 다음과 같은 결론을 얻었다. 1.전 질병의 연령적분포는 20세 이하로부터 55세 이상에 이르기까지 광범위하게 분포되어 있었고 25세 내지 35세에서 349예인 49.9%를 차지하고 있었다. 2.700예중 제왕절개가 320예로 45.7%였고 자궁적출술은 254예로 36.2%였고 난관절제 및 난소절제술은 91예로 13%였다. 3.제왕절개술은 25세내지 30세층에서 184예로 전체 320예의 57.5%였다. 제왕절개술의 중요 원인은 C.P.D.,태위이상, 전치태반,previous C-section등이었다. 제왕절개술의 방식은 Lower Segmental transverse method가 271예로서 84.7%였다. 4.자궁외임신은 20세부터 40세까지에서 전체 72예중 70예가 이 연령층에 속하여 97.2%였고, 25세 내지 30세층에서 가장 많아 26예 (36.1%)였다. 5.난소종양중 가장 많은 예는 버종양성난소낭종이였으며 이는 29예로 반수에 이르렀다. 수술방법으로는 난소종양절제술이 33예로서 56.9%였고 자궁적출술을 겸하였던 예는 23예로 39.7%였다. 6.자궁근종의 호발연령은 40세 내지 50세층으로 29예(50.9%)였고 주증상은 출혈과 복통이었다. 7.자궁경부암의 연령적 분포로는 40세 이상층에서 38예로 70.4%였고 가장 많은 발생율을 보인 군은 45세 내지 50세군이었다. 자궁경부암의 수술방법은 Radical hysterectomy가 22예로 40.8%였다. 8.골반강내 염증성질환의 발생분포는 25세부터 50세에 이르기까지 거의 비슷하게 발생하였으며 전체 40예중 34예(85.0%)에서 자궁적출을 겸하였다. 9.융모서질환은 역시 25세이상 50세에 이르기까지 거의 같은 비율로 발생하였으며 전체 23예에서 자궁적출술이 시행되었다. The studies on 700 cases such as age distribution, diagnosis, operative methods and symptoms were performed with cesarean section,ectopic gestation, ovarian tumor, myoma uteri,cervical carcinoma, pelvic inflammatory disease and trophoblastic disease during the period of 5 years from Jan.1971 to Dec. 1979. 1.The age distribution of all cases (700) ranged from less than the age of 20 year to 55 year. In the group from the age of 25 to 35 year, 349 cases(49.9%) were treated by abdominal laparotomy most frequentry. 2.In the same period, cesarean section was performed in 320 cases( 45.7%) and hysterectomy in 254 cases (36.2) and salpingectomy and oophorectomy iin 91 cases(13.0%). 3.Cesarean section was the most frequentry operative method that was from the age of 25 to 30 year, 184 cases (57.5%) were performed. The main indications of cesarean section were cephalo pelvic disproportion,malpresentation, previous cesarean section and placenta previa. 4.The common operative method of cesarean section was lower segmental transverse incision(84.7%). 5.Seventy cases of all ectopic gestation ranged from the age of 20 year to 40 year. 6.The most common cases of ovarian tumors were nonneoplastic cyst (50.0%0 and ovarian tumors also occupied at the age of 20 to 35 year in 29 cases( 50.0%). 7.Myoma uteri occurred mainly at the age of 40 to 50 year in 29 cases (50.9%) and the main symptoms were bleeding and abdominal pain. 8.The age distribution of cervical carcinoma showed over the age of 40 year in 38 cases (70.4%). 9.The age distribution of pelvic inflammatory disease showed evently from the age of 25 to 50 year and 34 cases among 40 cases(85.6%) were treated by hysterectomy. 10.Trophoblastic disease ranged from the age of 25 to 50 year and 23 cases were treated surgically.

제왕절개술에 관한 임상적 고찰

황용우(YW Hwang),이철진(CJ Lee),김현중(HJ Kim),최영희(YH Choi),서국재(KJ Suh) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.10

1. Cesarean section rate was 7.67%. 2. The age distribution of Cesarean section showed 57.5% between 25 and 30 year, 20.0% between 30 and 35 years, 14.7% between 20 and 25 years and 5.0% between 35 and 40 years respectively. 3. Indication for Cesarean section were C.P.D (40.9%) malposition (17.5%) placenta previa (8.4%) toxemia (3.1%) twin (2.5%) placental abruption (2.2%), and fetal distress (2.7%). 4. Among the indication of primary Cesarean section in multiparous dystocia was the most prevalent (44.2%) and the others were hemorrhage (18.4%) malposition (18.4%) and miscellaneous. 5. In the type of operation Lower cervical transverse type was most common(84.7%) and classical type was 10.6%. 6. The general anesthesia was performed at the rate of 90.94% and spinal was 9.06%. 7. Tubal ligation (15.3%) and appendectomy (5.6%) were performed coincidentally. 8. Among the Cesarean section cases, 266 cases (83.1%) were performed on emergency and the others electively. 9. The gestational ages at the time of operation were 40 weeks (30.0%) 41 weeks (16.6%) and 42 weeks (10.9%) 10. Apgar scores of the newborn in 2500 gram or more of baby weight was over 7 points at 286 cases (87.2%). 11. Maternal complications rate due to Cesarean section was 18.1% and mortality rate was 0.94%. 12. perinatal death rate of fetuses and newborn was 8.23%.

급성 심근경색 환자에서 일차적 관동맥 중재술시 Abciximab의 사용이 좌심실 재형성(Remodeling)에 미치는 영향

원경헌,이상훈,권현철,김현중,임을순,이호현 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.9