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5알파 환원효소억제제 복용 후 혈중 전립선특이항원의 변화
김현우(Hyeon Woo Kim),하홍구(Hong Koo Ha) 대한비뇨기종양학회 2012 대한비뇨기종양학회지 Vol.10 No.2
The aim of this review is to provide a discussion of serum prostate specific antigen (PSA) after use of 5α-reductase inhibitors (5αRIs). The 5αRIs that are used to treat benign prostatic hyperplasia may reduce operation risks and acute urinary retention. However, it causes alteration of serum PSA level requiring clinician’s attention. After two large studies, Prostate Cancer Prevention Trial (PCPT) and Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study, many literatures has showed that 5αRI reduces the prevalence of prostate cancer, especially in low grade cancer. However, the incidence of high grade prostate cancer increased in 5αRI group than placebo group. Recently, some authors revealed that serum PSA sensitivity to prostate cancer increased in the 5αRIs arm than placebo using serum PSA doubling rule, serum PSA density and increasing serum PSA after nadir level. The serum PSA is usually doubled in patients with 5αRIs more than 12 months because these decrease serum PSA level down to approximately 50% at 1 year compared to baseline. It seems to be such a simple method but may yield serum PSA overestimation during first 6 months and underestimation after 4 years of the use of 5αRIs. Some authors have reported serum PSA density is useful in increasing sensitivity to prostate cancer after 1 year use of 5αRI that reduce serum PSA noising effect of benign prostatic hyperplasia. Recently, increasing serum PSA after nadir level has been seemed to be an attractive method to detect prostate cancer in patients with use of 5αRIs.
경막외 스테로이드 주사(Epidural Steroid Injection : ESI) 시 C-arm의 두 가지 측방향에서 시술자의 피폭선량 평가
김현우(Hyeon-Woo Kim),심재민(Jae-Min Shim),정태섭(Tae-Seob Jeong),송창욱(Chang-Wook Song),방용식(Yong-Sik Bang) 대한인터벤션영상기술학회 2020 대한인터벤션영상기술학회지 Vol.23 No.1
목적 : 경막외 스테로이드 주사 시 C-arm 장비의 tube 위치에 따른 두 가지 측방향에서 시술자의 피폭선량을 평가해보고자 하였다. 대상 및 방법 : RS-113(Pelvis) 팬텀을 대상으로 Philips사의 Allura Xper FD 20 방사선 발생장치와 Unfors Xi 선량계를 이용하였다. 환자가 엎드린 자세를 기준으로 tube의 위치에 따라 Right tube, Left tube로 구분하였으며 측정 위치로는 대한민국 남성 평균 신장인 170 cm를 기준으로 눈(지면으로부터 160 cm높이), 흉부(지면으로부터 130 cm높이), 손(다섯 번째 허리뼈 위)의 위치로 지정하였다. 시술 시와 동일한 기하학적 구조를 유지한 상태로 tube의 위치와 측정 위치에 따라 선량계를 장축과 평행하게 위치시켜 0°(360°), 90°, 180°, 270° 모든 방향에서 각각 20회씩 측정하였다. Right tube에서 측정된 선량과 Left tube에서 측정된 선량을 통계학적 유의성 검정을 위해 독립표본 t검정으로 유의한 차이를 분석하였다. 결과 : Right tube의 경우 모든 방향에서 측정된 총 선량은 눈의 위치에서 평균 0.27 mR, 흉부 위치에서 평균 0.57 mR로 측정되었다. Left tube의 경우 눈의 위치에서 평균 0.09 mR, 흉부위치에서 평균 0.05 mR로 측정되었다. 그리고 LL5(Left Lumbar 5) 위의 손 위치에서 측정된 총 선량의 경우 Right tube에서 평균 96.76 mR, Left tube에서 평균 136.65 mR로 측정되었다. RL5(Right Lumbar 5) 위 손의 위치에서는 Right tube에서 평균 194.79 mR, Left tube에서 평균 76.1 mR로 측정되었다. 결론 : Right tube와 Left tube 시 각 위치에서의 선량 측정 결과 모든 측정 위치에서 유의한 차이가 있었다. 눈과 흉부의 위치에서는 차폐체에 의해 Left tube일 때 시술자가 받는 선량이 더 적은 것을 확인하였으며 손의 위치에서는 Right tube일 때 측정된 선량이 적은 것을 확인하였다. 이를 통해 시술하고자 하는 부위와 tube 사이의 거리가 멀수록 선량이 적은 것을 알 수 있었다. Purpose : To reduce the exposure dose received by the operator in Epidural Steroid Injection, we wanted to compare the dose in two directions depending on the tube position of the C-arm equipment. Materials and Methods : The RS-113(Pelvis) phantom was used with Allura Xper FD 20 radiation generator and the Unfors Xi dosimeter from Philips. Right tube and Left tube was divided according to the location of the tube based on the patient"s prone position, and the measurement area was eye(160 cm height from ground), chest(130 cm height from the ground), and hand(above the 5th Lumbar) location which were based on the average height of 170 cm for men in Korea. Dose was measured 20 times each in all directions at 0°(360°), 90°, 180° and 270°, parallel to the long axis, depending on the location of the tube and the specified area. The significant difference between the measured dose on the Right tube and on the Left tube was analyzed by the independent t-test analysis for statistical significance. Result : For the Right tube, the total dose measured in all directions was measured on average 0.27 mR in the eye and 0.57 mR in the chest. In the case of the Left tube, it was measured on average 0.09 mR in the eye and 0.05 mR in the chest. And for the total dose received by the operator"s hand at LL5(Left Lumbar 5) position, the average was 96.76 mR on the Right tube and 136.65 mR on the Left tube. At the RL5(Right Lumbar 5) position, the average was 194.79 mR on the Right tube and 76.1 mR on the Left tube. Conclusion : Dose measurements at each position during the Right tube and Left tube showed significant differences in all measurement positions. In the location of the eye and chest, it was measured that the operator received less doses by the shield when the tube located left. In the position of the hand, the longer the distance between the procedure area and the tube, the lesser dose was measured. It is considered that using a more specific dose measurement method by referring to these results will help in the study of reducing exposure dose for the operator.
MultiSAGE 모델과 ESG 지표를 적용한 상품 추천 시스템 개발
김현우 ( Hyeon-woo Kim ),김용준 ( Yong-jun Kim ),유길상 ( Gil-sang Yoo ) 한국인터넷정보학회 2024 인터넷정보학회논문지 Vol.25 No.1
최근 소비자들은 환경, 사회, 지배구조 관련 정보를 확인하고 더 나은 사회적 가치와 환경 친화적인 제품을 선택하려는 경향이 증가되고 있다. 본 논문에서는 GraphSAGE와 GAT를 결합한 모델인 MultiSAGE를 활용하여 최근 소비 트렌드인 가치소비에 맞추어 ESG 지표를 적용한 상품 추천 시스템을 제안하였다. 이를 위하여 한국 ESG 기준원에서 수집한 2022년 1,033개 기업의 ESG 등급 데이터와 실제 N기업의 쇼핑의 상품 데이터를 Heterogeneous Graph 형식의 데이터로 바꾸는 데이터 처리 과정과 MultiSAGE를 적용하여 머신러닝에 적용하고, 특정 상품을 입력하면 그 상품의 친환경 대체재를 추천해주는 추천 시스템을 구현하였다. 구현결과, 소비자들은 기업의 ESG지표를 적용한 제품을 쉽게 비교하여 구매할 수 있고, 이를 통해 사회적 가치와 환경친화적인 제품을 추천하는 시스템에 활용될 것으로 기대한다. Recently, consumers have shown an increasing tendency to seek information related to environmental, social, and governance (ESG) aspects in order to choose products with higher social value and environmental friendliness. In this paper, we proposes a product recommendation system applying ESG indicators tailored to the recent consumer trend of value-based consumption, utilizing a model called MultiSAGE that combines GraphSAGE and GAT. To achieve this, ESG rating data for 1,033 companies in 2022 collected from the Korea ESG Standard Institute and actual product data from N companies were transformed into a Heterogeneous Graph format through a data processing pipeline. The MultiSAGE model was then applied in machine learning to implement a recommendation system that, given a specific product, suggests eco-friendly alternatives. The implementation results indicate that consumers can easily compare and purchase products with ESG indicators applied, and it is anticipated that this system will be utilized in recommending products with social value and environmental friendliness.
참당귀 추출물의 청색광 유도 망막색소상피세포(ARPE-19) 손상으로부터의 보호 효과
김현우(Hyeon Woo Kim),이윤제(Youn Je Lee),강현본(Hyun Bon Kang),김형회(Hyeong Hoi Kim),송일대(Il Dae Song),강재선(Jae Seon Kang) 대한약학회 2022 약학회지 Vol.66 No.3
Light pollution such as blue light exposure can damage the visual photoreceptors and lead to cell death and degenerative retinal diseases. Despite the increasing number of patients suffering from retinal disease, the therapeutic agents are still insufficient. Angelica gigas Nakai extract (AGNEX) containing a high proportion of decursin derivatives has effectively protected cells under oxidative stress or high-level blue light. However, it remains unclear whether it protects retinal cells effectively. Here, we investigated the cytoprotective effect of AGNEX on retinal cells damaged using reactive oxygen species (ROS), which decreased the viability of retinal cells by causing oxidative stress. The cell viability with 600 μM hydrogen peroxide treatment was less than 70% of the normal control group. However, the group treated with 40 μM of AGNEX showed recovery as the normal control group. ROS levels were decreased in the AGNEX treated at 10-20 μM compared with the 600 μM hydrogen peroxide group. The AGNEX treated group was reduced by 20% compared with the untreated control group. This study suggests that AGNEX could prevent damage to blue light-induced retinal cells by oxidative stress relief, suggesting its potential as a therapeutic agent similar to eye care functional foods and as medicine against retinal cell damage.