서방정으로부터의 약물 용출에 대한 고분자-약물 상호작용의 영향

김행자,이승진 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2

To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCl and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion, whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.

호흡기능장애와 관련된 간호진단의 임상적용 : 중환자실 환자를 중심으로 Centered on MICU Patients

김행자,윤경이 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.2

This Study was done to improve practical application of three nursing diagnoses related to difficulty in respiratory function, ineffective airway clearance, ineffective breathing pattern, impaired gas exchange. The sample was 30 nursing records of patients in MICU at K University Medical Center in Seoul which applied three nursing diagnoses with related factors. defining characteristics, nursing interventions. These records were made by MICU nurses. For this study, MICU nurses had two weeks of education and practice period for the preparation to apply the nursing diagnoses, and then, during one month(April, 1995) they gained 30 nurses records from 30 patients with respiratory difficulties by applying three nursing diagnoses to them. Data were analyzed using descriptive statistics. The results of this study are summarized as follows ; 1. The number of cases of each nursing diagnosis was, · ineffective airway clearance, 14 cases, · ineffective breathing pattern, 10 cases. · impaired gas exchange, 6 cases. 2. The related factor of each nursing diagnosis was defined as : · increased secretion from the tracheobronchial tree in ineffective airway clearance, · decreased of lung expansion in ineffective breathing pattern, · alveolar hypoventilation in impaired gas exchange. 3. The main defining characteristics of each nursing diagnosis were defined as ; · dyspnea/SOB, cough with sputum, rhonchi/wheezing, inability to expectorate of sputum due to fatigue and decreased energy level in ineffective airway clearance, · tachypnea, dyspnea/SOB, decreased lung expansion, depressed cough reflex with medication in ineffective breathing pattern. · altered results of ABGA, cyanosis, tachycardia in impaired gas exchange. 4. The common defining characteristics of three nursing diagnoses were dyspnea/SOB and tachycardia. And distinguished defining characteristics of three nursing diagnoses were, ; cough with sputum, rhonchi/wheezing, inability to expectorate of sputum due to fatigue and decreased energy level in ineffective airway clear ance ; tachypnea, decreased lung expansion, anxiety/restlessness, depressed cough reflex with medication, in ineffective breathing pattern ; altered result of ABGA, cyanosis, tachycardia in impaired gas exchange. 5. The major domains in nursing interventions of each nursing diagnosis were ; · maintaining optimal hydration status, management for airway patency in ineffective airway clearance, · minimizing of energy loss, maintaining optimal hydration status in ineffective breathing pattern, · minimizing of energy loss, minimizing of oxygen demand in impaired gas exchange. 6. The common nursing interventions of three nursing diagnoses were frequent changing position, maintaining posture for lung expansion, suctioning, assessment of hydration status, applying humidifier, observation of trachoobronchial secretion, medication of bronchodilators, oxygen administration, observation of respiration pattern, auscultation of breathing sounds, monitoring the results of ABGA, observation of patient's reaction to oxygen therapy, bed rest, relieving of anxiety/restlessness. And specific nursing interventions of each nursing diagnosis were ; deep breathing and effective coughing, pulmonary physical therapy, medication of mucolytics, encouraging fluid intake in ineffective airway clearance semi-fowler's positioning, inducing the deep breathing for lung compliance, observation of using the respiratory accessary muscles, observation of sleep patternin ineffective breathing pattern. But, specific nursing intervention in impaired gas exchange not appeared.

서방정으로부터의 약물 용출에 대한 고분자-약물 상호작용의 영향

김행자,이승진 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6

To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCL and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion. Whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.

암의 예방책 및 조기 발견

김행자 대한간호협회 1978 대한간호 Vol.17 No.6

한국정치발전의 정향성을 위한 이론적 전제

김행자 한국정치학회 1979 한국정치학회보 Vol.13 No.-

기억의 숲에는

김행자 淑明女子大學校 藥學大學 1969 藥硏 Vol.5 No.1

12월 겨울삽화

김행자 淑明女子大學校 藥學大學 1969 藥硏 Vol.5 No.1

이완요법이 수술후 동통완화에 미치는 영향에 관한 연구

김행자 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.2

The purpose of this study is to examine the effects of relaxation technique on relief of postoperative pain This study was performed from March 4 to June 29, 1985 by nonegurvalent control group post-test only design method. The sample size for this study was 70 persons and selected from patients experiencing surgery-(resection or incision of the gall bladder/duct. stomach/intestine, kidney/ureter) who were hospitalized in two hospitals attached to K university medical center In Seoul. Seventy persons of sample was evenly divided into control group and study group. The study group was taught relaxation technique the evening before surgery The tools of this study were two kinds; pain scale is graphic rating scale, and observation of behavioral reaction pattern scale. The researcher used somewhat modified form of Kim's scales In this study, pain scores are the sum of obtained marks using above mentioned two scales Cronbach's alpha coefficient of these stales was 0.88 The researcher tested the hypothesis after confirming that there was no significant differences between control group and study group in similarity of specific characters influencing postoperative pain. The results of this study are as follows: 1. Main hypothesis that the degree of the postoperative pain in study group using relaxation technique will be lower than in control group using no relaxation technique was supported (t=-5.90, p<001) 2. Sub-hypothesis Ⅰ that study group using relaxation technique will perform an earlier ambulation than control group was accepted.(t=-2.69, p<.001) 3. Sub-hypothesis Ⅱ that study group using relaxation technique will reduce more the numbers of analgesics required for the first 48 postoperative hours than control group was supported.(t=-6.09, p<.001) Conclusively, this study reveals that relaxation technique is effective in relieving postoperative pain, makes it possible to perform an earlier ambulation, and reduces the requirements of analgesics for postoperative patients.

양습관 형성을 위한 보건위생교육 실천방안

김행자,Kim, Haeng-Ja 한국학교보건협회 1982 학교보건 Vol.11 No.-

부 부재와 청소년기의 가치관 발달과의 관계 : 고등학교 학생을 중심으로

김행자 건국대학교 1993 學術誌 Vol.37 No.2

The purpose of this study is to review whether there is any correlation between the development of the view of value and the broken family or fatherless family especially in the case of adolescents. It is necessary to compare the view of value of the adolescents from the broken family with that from the normal family in order to suggest the ways of developing a desirable view of value for the sake of adolescents from the broken or fatherless family. In this study an attempt is made to see the role of a father in the development and formation of adolescents' view of vague. The result of this study is as follows : 1.The presence of a father in a family does not mean much in the development of adolescents' view of value. That is, the role of a father in a family matters little to the development of adolescents' view of value. What matters is not the presence of a father in a family but what a father does in a family. 2.Having closely analyzed the causes of difference in adolescents' view of value one can conclude that there is a significant difference among the children from the broken family in terms of the view of value related to the family. This is probable because the presence and the role of a mother can take over the place and the role of a father in a family. Adolescents from the broken family by the death of their father make more positive response to the role of their parents than those by the divorce or separation of their parents. 3.The age at the time when adolescents lost their fathers does matter little to the development of their view of value. This is because the adolecents take it for granted that they should live alone without any help from their fathers as they grow older. The fact that they don't live with their fathers is no longer a problem for the adolescents. 4.It appears that there is no significant correlation between the causes of the fatherless family and the development of value system of adolescents. 5.A more systematic study on the areas related to the development of adolescents' view of value and on the effects of the interactions among the areas concerned is deemed necessary, is needed.