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유두부선암에서 비정상 p53 유전자의 빈도 및 임상적 의의
박종재(Jong Jae park),현진해(Jin Hai Hyun),조현이(Hyun I Cho),김재선(Jae Sun Kim),최재현(Jae Hyun Choi),김한겸(Han Gyum Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu) 대한내과학회 1999 대한내과학회지 Vol.57 No.1
Although abnormalities of p53 gene and their relation to clinicopathologic parameters have been identified in some human malignancies, there is little published data on their prevalence and clinical significance in ampullary adenocarcinoma (AAC). The aim of this study is to determine the prevalence of p53 abnormalities in AAC and to evaluate their relation to clinicopathologic features. Method : 35 formaline-fixed paraffin-embedded tissues of AAC were examined for detection of p53 abnormalities by both single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction- amplified DNA fragments corresponding to exons 5-8 and immunohistochemistry (IHC) using monoclonal antibody to p53 protein (Novocastra, DO7), and the association between the p53 abnormalities and clinicopathologic parameters was analyzed. Result : In 22.9% of AAC, p53 gene muation was demonstrated by SSCP analysis, mainly at PCR-amplified exon 8 and exon 7. The p53 protein overexpression by IHC was 48.6% of AAC. Six SSCP and IHC-positive (17.2%) cases and 16 normal (45.7%) cases showed concordant results between the methods, although 13 cases (37.1%) showed discordance, including 11 IHC-positive (31.4%) and 2 SSCP-positive (5.7%) cases. Overall, the prevalence of p53 abnormalities was 54.3%. No significant associations between the p53 abnormalities and clinicopathological parameters such as clinical manifestations, histologic differentiation, and tumor stage were observed. Conclusion : The p53 abnormalities detected in 55% of AAC are not associated with prognostic factor, suggesting that abnormal p53 gene may play a role in the development of AAC, but not in its invasiveness.
연구보고 : 천식 환자의 기관지 조직에서 Eotaxin mRNA 발현에 관한 연구
인광호 ( Kwang Ho In ),조재연 ( Jae Yun Cho ),강세용 ( Sae Yong Kang ),이상엽 ( Sang Youb Lee ),심재정 ( Jae Jeong Shim ),강경호 ( Kyung Ho Kang ),유세화 ( Se Hwa Yoo ),나영순 ( Young Soon Na ),김한겸 ( Han Gyum Kim ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.4