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축산물 및 가공 : 원유내 내냉성 미생물의 오염에 따른 유리 D-amino acid의 생성
김철현 ( Kim Cheol Hyeon ),송영민 ( Song Yeong Min ),백승천 ( Baeg Seung Cheon ) 한국축산학회 2004 한국축산학회지 Vol.46 No.1
It is generally believed that amino acids occurring naturally in mammals are of the L-configuration. D-amino acid(DAA) are common in nature as constituents of bacterial of bacterial cell walls and several antibiotics. Recent reports have demonstrated the presence of small amounts of free DAA in milk. The presence of free DAA may affect the food quality by decreasing the nutritional value. Our objective was to examine whether the free DAA came from psychrotrophic bacteria. Free DAA was produced by treating raw milk with Pseudomonas spp. The samples were extracted with sulphosalicylic acid and derivatized with AccQ-Tag^(TM) reagent when the analysis was carried out by reverse-phase HPLC. We tested correlations of the content of free DAA with bacterial growth. Significant amounts of free D-alanine and D-proline have been found in the raw milk inoculated with Pseudomonas spp. The increase of D-alanine and D-proline appeared to be mainly related to the presence of Pseudomonas fluorescens. There results suggest that free DAA may be considered as an indicator of psychrotrophic bacterial milk contamination.
과공정 Al-Si 합금의 열팽창 특성에 미치는 Si 입자 크기의 영향
김철현 ( Kim Cheol Hyeon ),주대헌 ( Ju Dae Heon ),김명호 ( Kim Myeong Ho ),윤의박 ( Yun Ui Bag ),윤우영 ( Yun U Yeong ),김권희 ( Kim Gwon Hui ) 한국주조공학회 2003 한국주조공학회지 Vol.23 No.4
N/A Hyper-eutectic Al-Si alloy is used much to automatic parts and material for the electronic parts because of the low coefficient of thermal expansion, superior thermal stability and superior wear resistance. In this work, A390 alloy specimens were fabricated for control of the Si particle size by various processes, such as spray-casting, permanent mold-casting and squeeze-casting. To minimize the effect of microporosity of the specimen, hot extrusion was carried out under equal condition. Each specimens were evaluated tensile properties at room temperature and thermal expansion properties in the range from room temperature to 400℃. Ultimate tensile strength and elongation of the spray-cast and extruded specimens which have fine and well distributed Si particles were improved greatly compare to the permanent mold-cast and extruded ones. Specimens which have finer Si particles showed higher ultimate tensile strength and elongation than those having large Si particle size, and coefficient of thermal expansion of the specimens increased linearly with Si particle size. In case of the repeated high temperature exposures, thermal expansion properties of the spray-cast and extruded specimens were found to be more stable than those of the others due to the effect of fine and well distributed Si particles.
미만성 범세기관지염 환자의 Erythromycin 치료후 장기 경과
김철현(Cheol Hyeon Kim),고원중(Won Jung Kho),장승훈(Seung Hun Jang),유철규(Chul Gyu Yoo),김영환(Young Whan Kim),허대석(Dae Seog Heo),한성구(Sung Koo Han),심영수(Young Soo Shim) 대한내과학회 1997 대한내과학회지 Vol.53 No.3
Background: Diffuse panbronchiolitis(DPB) is a chronic inflammatory disease affecting the respiratory bronchioles which was first described in Japan in 1966. DPB is prevalent in Japan and is known to be very rare in western countries. The first cases of DPB were reported in Korea in 1992 and the number of the patients has been increasing. The prognosis of DPR had been very poor because there had been no effective treatment for the disease. Hut it has been dramatically changed since the introduction of low-dose long-term erythromycin therapy. In Korea, there is rare experience of 1ong-term follow-up of DPH patients and we presents the results of mean 21.6 months of follow-up after erythromycin treatment. Methods: We analyzed the long-term follow-up data of 25 DPH patients who were diagnosed in Seoul National University Hospital during the period from September 1989 to December 1994 and followed up more than 6 months with erythromycin therapy. We tried erythromycin 250mg b.i.d. on all the patients and analyzed the changes of subjective symptoms, physical signs, pulmonary function tests, and chest X-rays. Results: 1) The mean follow-up period was 21.6 months. 2) Subjective symptoms improved in 96% of the patients within 3 months and 76% of the patients showed no symptom after 18 months of treatment. 3) Crackles and wheezing decreased in all patients within 3 months and completely disappeared in 76% of the patients after 18 months of treatment. 4) Diffuse small nodular lesions on chest X-ray decreased in 56% of the patients within 3 months and chest PA was normal in 32% of the patients after 12months of treatment. 5) FVC and FEV1 increased remarkably during the first 3 months and slowly increased thereafter, reaching normal level after 12 months of treatment. FEV1/FVC was 60.4% before treatment and in- creased slowly reaching 76.1% after 24 months of treatment. 6) Erythromycin therapy could be finished in 7 patients. The mean duration of medication was 26 months and no evidence of recurrence was found in 6 months of follow-up. 7) No patients had experienced the side effect of erythromycin, Conclusion : The prognosis of DPR is very goad when treated with erythromycin. And at least 2 years of erythromycin treatment seems to be needed for DPB patients.
NCCN 암성 통증 가이드라인에 따른 폐암 환자의 암성 통증 조절
김현태 ( Hyeon Tae Kim ),고경원 ( Kyung Won Koh ),김여명 ( Yeo Myeong Kim ),강민수 ( Min Soo Kang ),노희선 ( Hee Sun Noh ),김혜련 ( Hye Ryoun Kim ),김철현 ( Cheol Hyeon Kim ),이재철 ( Jae Cheol Lee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3
Background: Pain is one of the most troublesome problems caused by malignancy. We evaluated the change in pain status according to observance of NCCN guidelines in lung cancer patients. Methods: Lung cancer patients complaining of pain at admission were examined. The pain was assessed with visual analogue scale (VAS) for 20 days and moderate-to-severe pain was defined as more than VAS level 3. The guideline observance was classified as high (more than 80%), medium (50∼79%) and low (less than 50%). Results: Among the total 91 lung cancer patients with pain, 34 patients (37%) had moderate-to-severe pain. Their average VAS score at admission was 5.6. It decreased to 2.9 after a 20-day period of pain management. The time to reach a VAS less than 3 was 3 days in a high guideline observance group, while it took 6 days in a low observance group. In addition, the pain in the high observance group was controlled to less than 3 VAS level in 86% of patients, whereas only 25% of patients in the low observance group succeeded. Conclusion: Pain was more effectively controlled when the dose of drugs was modified according to NCCN guidelines in lung cancer patients indicating the importance of guideline observance in pain management.
삼첨판 폐쇄 부전증에서 연속파형 Doppler 심초음파 검사에 의한 우심실 및 폐동맥 수축기압 추정에 관한 연구
김육 ( Kim Yug ),조주영 ( Jo Ju Yeong ),김철현 ( Kim Cheol Hyeon ),김학선 ( Kim Hag Seon ),조영덕 ( Jo Yeong Deog ),김홍수 ( Kim Hong Su ),박노춘 ( Park No Chun ),서세웅 ( Seo Se Ung ),김성구 ( Kim Seong Gu ),권영주 ( Kwon Yeong 대한내과학회 1992 대한내과학회지 Vol.42 No.3
To determine noninvasive estimation of systolic right ventricular and pulmonary artery pressure by continuous wave Doppler echocardiography. We analyzed continuous wave Doppler echocardiography and cardiac catheterization data in 16 patients with tricuspid regurgitation undergoing right heart catheterization. Peak velocity of systolic tricuspid regurgitation flow by continuous wave Doppler echocardiography was 254.0±71.0 ㎝/sec and calculated pressure gradient between right ventricle and atrium was 26.9±12.8 ㎜Hg. Peak velocity and pressure gradient of systolic tricuspid regurgitation flow in continuous wave Doppler echocardiography significantly correlated with systolic right ventricular pressure (r=0.84 p<0.001, r=0.87 p<0.001) and systolic pulmonary artery pressure (r=0.82 p<0.001, r=0.87 p<0.001) measured by right heart catheterization. Deceleration rate of systolic tricuspid regurgitation flow significantly correlated with peak velocity (r=0.90 p<0.001) and pressure gradient (r=0.92 p<0.001) by continuous wave Doppler echocardiography also significantly correlated with systolic pressure gradient (r=0.82 p<0.001) between right ventricle and right atrium measured by right heart catheterization. In conclusion, we could noninvasively estimate systolic right ventricular and pulmonary artery pressure in the patients with tricuspid regurgitation by analyzing peak velocity, pressure gradient and deceleration rate by continuous wave Doppler echocardiography.
Gonadotropin-releasing Hormone (GnRH) Analogue로 치유된 Catamenial Hemoptysis
김대한 ( Kim Dae Han ),서요안 ( Seo Yo An ),김상일 ( Kim Sang Il ),최귀성 ( Choe Gwi Seong ),손현배 ( Son Hyeon Bae ),권용주 ( Kwon Yong Ju ),김성호 ( Kim Seong Ho ),김철현 ( Kim Cheol Hyeon ),이재철 ( Lee Jae Cheol ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.3