갑상선기능항진증환자에서 소장운동성의 동태 변화

김연근(Yeon Keun Kim),서정은(Jung Eun Suh),임규성(Kyu Sung Rim),유재영(Jae Young Yoo),이영천(Young Cheon Lee),김교명(Kyo Myeong Kim),권혁일(Hyeok Yil Kwon),박형진(Hyoung Jin Park) 대한내과학회 1990 대한내과학회지 Vol.38 No.2

It is well-known that hyperthyroidism is associated with gastrointestinal (GI) motility disorders, such as frequent defecations and diarrhea. However, few studies have done a manometric analysis of GI motility, particularly the migrating motor comples (MMC

ASTM Gr.92강의 미세조직 및 기계적 성질에 미치는 템퍼링 온도 및 열처리경로의 영향

김연근 ( Yeon Keun Kim ),한창희 ( Chang Hee Han ),백종혁 ( Jong Hyuk Baek ),김성호 ( Sung Ho Kim ),이찬복 ( Chan Bock Lee ),홍순익 ( Sun Ig Hong ) 대한금속·재료학회 2010 대한금속·재료학회지 Vol.48 No.1

In order to investigate the effects of tempering temperature and heat-treatment path on the microstructural and mechanical properties of ASTM Gr.92 steels, foul samples with different tempering temperatures and heat-treatment paths were prepared. Three experimental steels showed tempered martensitic microstructures. but the sample tempered at 8l0℃ was presumed to retain partially untempered martensitic microstructures due to a lower α+γ phase regime. M23C6. V(C,N), and Nb(C.N) precipitates were observed in all samples. In addition, Cr2N was observed to be precipitated finely and uniformly by isothermal heat-treatment. The lath width and precipitate size increased with an increase of the tempering temperature. In particular, the lath width and precipitate size in the isothermal heat-treated samples were much smaller than those of the tempered-only specimens. Because of a fine and uniform precipitate, a reduction of lath width would enhance precipitation hardening, and it was shown that mechanical propertiesincluding the hardness and tensile properties of the steels were improved by isothermal heat-treatment.

소세포 폐암의 유두부 전이에 의한 폐쇄성 황달

박홍배(Hong Bae Park),임연근(Yeun Keun Lim),여향순(Hyang Soon Yeo),장진형(Jin Hyeong jang),김연종(Yeon Jong Kim),김호동(Hou Dong Kim),윤형신(Heyong Shin Yoon),이윤호(Youn Ho Lee),손장신(Jang Shin Sohn) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6

A 56-year-old man was admitted to our hospital because of jaundice. His chest radiography revealed a mass lesion in the left upper lung. Bonchoscopic lung biopsy was performed and the pathological diagnosis was small cell carcinoma of the lung. In his clinical course, obstructive jaundice developed during combination chemotherapy. The findings of abdominal ultrasonography, duodenoscopy with biopsy and percutaneous transhepatic cholangiography suggested that jaundice was developed by extrahepatic biliary obstruction with ampulla of vater metastasis. We experienced one case of obstructive jaundice by ampullary metastasis of small cell carcinoma of the lung cancer in 56-year-old man.

APACHE 3 를 이용한 내과 중환자실 환자의 질병 중증도 평가

유진홍(Jin Hong Yoo),김연근(Yeon Keun Kim),신완식(Wan Shik Shin),강문원(Moon Won Kang) 대한내과학회 1996 대한내과학회지 Vol.50 No.3

N/A Objectives : In order to quantify the risk for medical intensive care unit (ICU) patients and to establish the guideline for decision making by using Acute Physiology and Chronic Health Evaluation (APACHE) III score. Methods : Total 204 medical ICU patients from July-1993 to September-1993 were enrolled to this study. Patients were categorized into subgroups by major disease cateogories, We measured acute physiologic variables, age, comorbidities, and chronic health status according to the APACHE III scoring system. Logistic regression analysis was done to determine the relationship between APACHE III score and death risk. Results : The overall mortality rate of 204 medical ICU patients was 28.4% (58/204). The majority of patients showed standard distribution over 17~72 APACHE III points. The main APACHE III point of survived group(n=146) was significantly lower than that of non-survived group(n=58), 43.6 vs 69.4, respectively(p<0.01). Logistic regression analysis about the relationship between APACHE III score and death risk gave the equation like this: logn R/1-R= 0.04314×(APACHE III)-3.488 According to this equation, the estimated risk of death was over 50% at the point range of 80~85 and over 90% at 130~135. Conclusion: APACHE IU scoring system could be a useful guideline to predict and to evaluate the outcome in medical ICU patients and it would aid us in clinical decision making and proper management of ICU patients.

패쇄성 황달을 동반한 간흡충 감염증에 있어서 내시경적 유두절개술의 의의

윤형신(Hyeong Shin Yoon),김연종(Yeon Jong Kim),김호동(Hou Dong Kim),장진형(JIn Hyeong Jang),임연근(Yeun Keun Lim),여향순(Hyang Soon Yeo),박홍배(Hong Bae Park) 대한내과학회 1992 대한내과학회지 Vol.43 No.6

N/A Background: Clonorchiasis is very common in the Far East, especially southern China, Taiwan, Hong Kong, Japan, and Korea, where raw or undercooked fish has long been considered a delicacy. In Korea, people who live in the vicinity of the major four rivers are most frequently infected. 3ome percentage of infected individuals will develop the symptoms of chronic clonorchiasis, which include inflammation, infection, stones, obstruction, and neoplastic changes in the biliary tree. Methods: To evaluate the effects of EST in clonorchiasis patients with obstructive jaundice, 73 patients underwent EST as a method of biliary drainage after praziquantel therapy between August 1989 and July 1991. All of the patients were diagnosed as having clonorchiasis by the stool examination and ERCP and as having obstructive jaundice according to their blood chemistry findings. Results: (pt.; patient) 1) 73 patients, 54 male (74%) and 19 female (26%), underwent EST 1.14 times in average (from 1 to 3 times). 2) The associated diseases of the patients at presentation were biliary stones (22 pt., 30%), pancreatitis (16 pt., 22%), biliary tumors (8 pt., 11%) and liver cirrhosis (5 pt., 7%). 3) AST, ALT, alkaline phosphatase and direct and total serum bilirubin were significantly improved in 32 patients (44%) within 1 week after EST and 63 patients (86%) within 4 weeks after EST (p<.0.01). 4) 10 patients (14%) with biliary tumors (5 pt., 7%), liver cirrhosis (4 pt., 5%) and CBD stone (1 pt., 1%) were not improved in their blood chemistry. 5) Complications (9 pt., 12%) were acute pancreatitis (6 pt., 8%), major bleeding (2 pt., 3%) and acute cholangitis (1 pt., 1%). Conclusion: EST is the very effective, convenient, safe and non-surgical method of biliary drainage in clonorchiasis patients with obstructive jaundice. But it is of little value in most of the patients with biliary tumors and liver cirrhosis.

간장 및 담도 : 만성 B형 간질환 환자에서 각종 바이러스 증식 표지자의 출현동태

유재영(Jae Young Yoo),박충기(Choong Kee Park),김우중(Woo Joong Kim),김태빈(Tae Bin Kim),고순희(Soon Hee Koh),계세협(Sea Hyub Kae),신효균(Ho Kyun Shin),김연근(Yeon Keun Kim),임규성(Kyu Sung Lim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

N/A We studied several viral replication markers of hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma to evaluate the clinical significance of thesemarkers in serum. The patients comprised of 43 males and 8 females, and ages from 17 to 64 (mean: 34) years. All patients were sero-positive for hepatitis B surface antigen (HBsAg). Histologically, 36 patients showed chronic active hepatitis and 15 showed hepatocellular carcinoma. The viral replication markers tested were hepatitis B e antigen (HBeAg), antibody to hepatitis B e antigen (anti-HBe), Immunoglobulin M antibody to hepatitis B core antigen (IgM anti-HBc), DNA polymerase and hepatitis B virus deoxyribonucleic acid (HBV-DNA). The results were summerized as follows. 1) The younger the patients, the higher was the positive rate of HBeAg; the older the patients, the higher was the positive rate of anti-HBe. 2) There was a reverse correlation between the age and the level of serum alanine aminotransferase (ALT); the younger the patients, the higher was the titer. But no correlation was noted between age and the level of serum aspartate aminotransferase (AST). 3) The histologic findings of the liver tended to be more severe in older patients. The patients with hepatocellular carcinoma were the oldest group. 4) The positive rate of HBeAg was higher in patients with chronic hepatitis than in patients with hepatocellular carcinoma. but there was no difference between these two groups in the positive rate of IgM anti-HBc. 5) The positive rate of HBV-DNA and DNA polymerase was 63% and 35%, respectively, and their titers were significantly low. 6) There was no significant correlation between the positive rate of HBeAg, IgM anti-HBc, HBV-DNA, and DNA polymtrase. On the basis of these findings, it is suggested that the natural history of chronic hepatitis B of Koreans might be different from that of Caucasians; the positive rate and the titers of the viral replication markers were lower in Koreans.

갑상선기능항진증환자에서 소장운동성의 동태 변화

서정은,유재영,임규성,박형진,권혁일,김연근,이영천,김교명 대한내과학회 1990 대한내과학회지 Vol.39 No.2

It is well-known that hyperthyroidism is associated with gastrointestinal (GI) motility disorders, such as frequent defecations and diarrhea. However, few studies have done a manometric analysis of GI motility, particularly the migrating motor comples (MMC) in patients with hyperthyroidism. The changes of MMC period and each phase occurred in patients with hyperthyroidism are considered as a candidate of the magjor causes for GI manifestations. The aim of this study was to observe the changes of GI motility as measured by manometry as well as the relationship between the changes of GI motility and GI manifestations in patients with hyperthyroidism. This study was performed on nine patients with hyperthyroidism and six control subjects, The results were as follows: 1) MMC periods in the duodenum and proximal jejunum in patients with hyperthyroidism were significantly shortened in comparison with the control subjects (p$lt;0.05). 2) A shortening of Phase l and prolongation of Phase II occurred in patients with hyperthyroidism in comparison with the control subjects (p$lt;0.05, p$lt;0.01, & p$lt;0.001). 3) The frequency of contractions of Phase Ⅲ in the duodenum and upper iejunum in patients with hyperthyroidism significantly increased in comparison with the control subjects(p$lt;0.05 & p$lt;0.01). 4) The propagation velocity of Phase III in the duodenum and upper jejunum in patients with hyperthyroism was not significantly faster than in the control subjects.