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임하나,진소영,정영도,김성보,장동진,김성태 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-
The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD), widely usedas a solubility enhancer, on liposomal formulations. To this end, HPβCD was added to fabricate liposomesduring the hydration process, and their physicochemical properties were evaluated. The Fouriertransform infrared and nuclear magnetic resonance spectra revealed that HPβCD could interact with themodel drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. Thisleads to a rapid release of CAZ depending on the concentration of HPβCD. Nanosized HPβCD-incorporatedliposomes complied with Korsmeyer–Peppas kinetics, and the release of drug increased withoutsignificant changes in the release pattern. Our approach, which relied on supramolecule-relatedinteractions, could provide new insights into other lipid-based formulations for accelerating drug-releaseproperties.