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한양방 협진 치료를 통해 호전을 보인 주상(酒傷)으로 인한 급성 복통 환자 1례
김상범 ( Sang Bom Kim ),박재우 ( Jae Woo Park ),조종관 ( Chong Kwan Cho ),이연월 ( Yeon Weol Lee ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.21 No.1
Objective : This study was aimed to report a patient accompanied by alcoholic derogation acute abdominal pain treated with oriental medicine combined with conventional treatment. Methods : A 36 year old female patient complained of acute abdominal pain for one year from Apr. 2009. She had treated at local general hospital. But the symptom was not reduced. Instead, it was aggravated on Jul. 2010. The main symptoms were left flank pain, chest discomfort, nausea and anorexia. The patient was treated by oriental medicine (herbal medicine (Chunggan-plus), acupuncture, moxibustion, etc) combined with conventional medicine from Jul. 10th, 2010 to Jul. 17th, 2010. We observed the patient with evaluation of laboratory test and imaging scan. Results : Most of the symptoms of the patient were improved. Especially, the abdominal pain were disappeared from grade 3 to grade 0. No side effects were noted during treatment. Conclusion : This results suggest that the oriental medicine combined with western medicine may effective to treat alcoholic derogation acute abdominal pain.
생기액(生肌液)의 세포독성 및 자궁경부암 바이러스 (HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과
정옥(Ok Joung),조영식(Young Sik Cho),조정원(Cheong Weon Cho),이경애(Kyung Ae Lee),심정현(Jung Hyun Shim),조민철(Min Chul Cho),이홍수(Hong Soo Lee),염영일(Young Il Yeom),김상범(Sang Bom Kim),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2000 약학회지 Vol.44 No.4
Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner. In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.
제1요추 골절에 동반된 분리형 척수원추 증후군 : 1례보고 A Case Report
김경철,황정수,정필현,차웅남,강석,김용민,안영언,조창성,김상범 대한척추외과학회 1995 대한척추외과학회지 Vol.2 No.1
The conus medullaris syndrome, which means injury of the sacral cord(conus) and nerve roots within th spinal canal, is very rare. It is usually associated with injury or disease of thoracolumbar vertebrae(T12-L1) and results in areflexic bladder, bowel and loss of sensory and motor function of lower extremities. Between the two types of conus medullaris syndrome, isolated type(lesion of sacral cord alone) is more rare than the mixed type(lesions of both the cauda equina and conus medullaris). Clinical features of isolated conus medullaris syndrome are loss of bladder, external anal sphincter and sexual function. We experienced a case of isolated conus medullaris syndrome associated with L1 bursting fracture, which showed neurologic deficits confined to areflexia of bladder and anal sphincter without any sensory and motor dystunctions of lower extremities. The patient was managed with posterior decompression and posterolateral fusing using C-D instrumentation and showed gradual recovery of the neurologic deficits.