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김기만(K . M . Kim),김현수(H . S . Kim),김승인(S . I . Kim),김영일(Y . I . Kim) 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.4
Rifampicin sustained-release micropellets were prepared by spray congealing micropelleting technique using gelatin as the embedding matrix. The pellets were hardened by treating with formalin-isopropanol mixture. The in vitro release rates of rifampicin from the gelatin micropellets which were prepared with the different concentrations of formalin solution were determined in the following dissolution media for 8 hours; a) pH 1.2 buffer solution(USP XXI). b) distilled water. c) pH 7.4 buffer solution(USP XXI). d) pH 1.2 buffer solution for 1.5 hours and pH 7.4 for 6.5 hours thereafter. From the results of the dissolution study, following results were obtained; 1) It was observed that the rate of drug release from the prepared micropellts followed first-order release kinetics. 2) It was found that the change of the release rates was not dependent on the drug-gelatin ratio, but on the concentration of formalin and the time of hardening. 3) It could also be noticed that the increase in the release rates was more pronounced in pH 7.4 of dissolution medium rather than in pH 1.2. This fact might be attributed to the swelling property of gelatin in the dissolution medium.