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Polymeric Nanoparticles and Hydrogels for Therapy
Heebeom Koo(구희범) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
In this century, nanoparticles (NPs) have been given a great amount of attention by biomedical researchers. NPs can disperse hydrophobic drugs stably in aqueous conditions without aggregation. Importantly, their physicochemical properties, including size and surface charge, can easily be modified by adjusting the component molecules or fabrication method. NPs can delay the early release of drugs in order to allow enough time for therapeutic action. Along with NPs, hydrogel is also another representative material for biomedical applications. Hydrogels are three-dimensional network that contain large amount of water, and have used for drug delivery, cell therapy, and tissue engineering. In our recent studies, polymeric NPs and hydrogels have shown promising results in hearing loss and vocal cord paralysis, respectively.
Hyaluronidase-Sensitive SPIONs for MR/Optical Dual Imaging Nanoprobes
이동은,김광명,Gurusamy Saravanakumar,구희범,권익찬,최귀원,박재형 한국고분자학회 2011 Macromolecular Research Vol.19 No.8
This study developed new enzyme-specific superparamagnetic iron oxide nanoparticles (SPIONs) with potential as a multimodal probe in magnetic resonance (MR) imaging and optical imaging. For the MR/optical dual imaging, SPIONs were coated with near-infrared fluorescence dye (Cy5.5)-labeled hyaluronic acid (Cy5.5-HA),which could be readily degraded by hyaluronidase (HAdase). The presence of HA on the coated SPION was confirmed using FTIR, X-ray diffraction, and thermogravimetric analysis. Physicochemical analyses of Cy5.5-HAcoated SPIONs (Cy5.5-HA-SPIONs) demonstrated their higher colloidal stability and T2 relaxivity than bare SPIONs. When Cy5.5-HA-SPIONs were exposed to the MR instrument for the phantom test, the dark intensity of their T2-weighted image increased in a Fe concentration-dependent manner, suggesting potential as the MR probe. To examine their ability as the enzyme-sensitive optical probe, the fluorescent signals of Cy5.5-HA-SPIONs were measured in the absence or presence of HAdase. In the absence of HAdase, Cy5.5-HA-SPIONs showed a negligible fluorescent signal due to possible quenching between a SPION and fluorescence dye, and self-quenching effect of Cy5.5 molecules. On the other hand, in the presence of HAdase, the fluorescent signal of Cy5.5-HA-SPIONs increased dramatically as a function of the HAdase concentration, resulting from the degradation of the HA backbone. These results suggest that the Cy5.5-HA-SPION is useful as a multimodal nanoprobe for MR imaging and HAdase-sensitive optical imaging.
Application of click chemistry in nanoparticle modification and its targeted delivery
Gawon Yi,Jihwan Son,Jihye Yoo,Changhee Park,구희범 한국생체재료학회 2018 생체재료학회지 Vol.22 No.2
Background: Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction. Main body: Herein, we provide an update on recent application of click chemistry in nanoparticle research, particularly nanoparticle modification and its targeted delivery. In nanoparticle modification, click chemistry has been generally used to modify biological ligands after synthesizing nanoparticles without changing the function of nanoparticles. Also, click chemistry in vivo can enhance targeting ability of nanoparticles to disease site. Conclusion: These applications in nanoparticle research were hard or impossible in case of traditional chemical reactions and demonstrating the great utility of click chemistry.