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곽승기(Seung Ki Kwok),장우임(U Im Chang),이태규(Tae Kyu Lee),추교영(Kyo Young Choo),김진일(Jin Il Kim),박수헌(Soo Heon Park),한준열(Joon Yeol Han),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
Tuberculosis of the abdominal wall is relatively uncommon and most cases were caused by a spread of the infection from tuberculous abdominal lymph nodes. Autopsy studies have shown abdominal wall involvement in less than 1% of patients who died of tuberculosis. We have experienced a case of the tuberculous abscess in the abdominal wall. A 21-year-old woman was admitted for the evaluation of a soft mass at the right upper abdomen. A 15×5×4 cm sized abscess in the abdominal wall was detected by ultrasonogram and CT. Abscess was drained by ultrasonogram-guided aspiration. The confirmed diagnosis of tuberculous abscess was made by means of polymerase chain reaction of the aspirated fluid from the mass. The patient was successfully treated with anti-tuberculosis therapy of four drug regimens. To our knowledge, this is the first report of tuberculous abscess developed in the abdominal wall in Korea. (Korean J Gastroenterol 2001;38:220-223)
곽승기 ( Seung Ki Kwok ) 대한내과학회 2015 대한내과학회지 Vol.89 No.3
Sjogren`s syndrome is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands resulting in a dry mouth and eyes. The disease can present either alone or in association with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and inflammatory myopathy. In addition to symptoms caused by exocrinopathy, about half of patients present with extraglandular (systemic) manifestations including arthritis, Raynaud`s phenomenon, lymphadenopathy, vasculitis, peripheral neuropathy, and interstitial nephritis. Patients often suffer from severe fatigue, myalgia, and dryness, which lead to a poor quality of life. Physicians should be aware of the increased risk of lymphoma development in patients with Sjogren`s syndrome. Currently, there are no drugs available that are able to improve the natural course of disease, making symptom relief the primary goal of therapy. Currently, pilocarpine is the only drug clinically proven for the treatment of dry eyes and mouth in patients with Sjogren`s syndrome. (Korean J Med 2015;89:291-294)
류마티스관절염 환자에서 TNF-α 길항제 사용 시 결핵 발병에 대한 예방법
곽승기 ( Seung Ki Kwok ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.2
Introduction of tumor necrosis factor (TNF) inhibitor for the treatment of rheumatoid arthritis (RA) induces not only significant improvement of symptoms and signs of RA but also substantial inhibition of progressive joint damage. Such therapeutic efficacies of TNF inhibitor have led to a paradigm shift in the treatment of RA. In spite of its dramatic effect against RA, it is now well established that the use of TNF inhibitor significantly increases the risk of tuberculosis in patients with RA. Therefore some countries have presented guidelines in the use of TNF inhibitors for rheumatoid arthritis to reduce the risk of tuberculosis. Korea Food and Drug Association (KFDA) have also provided guidelines for treating latent tuberculosis when using TNF inhibitors. In this article, we reviewed the general epidemiology of tuberculosis and incidence rates of tuberculosis in RA patients and those of RA patients treated with TNF inhibitors. We also introduced methods for the diagnosis of latent tuberculosis, and various guidelines published in different countries in managing tuberculosis in RA patients who were to be treated with TNF inhibitors. Finally, we suggest requirement of more appropriate guidelines for Korean RA patients who are candidates for treatment with TNF-inhibitors.
곽승기 ( Seung Ki Kwok ),박성환 ( Sung Hwan Park ),박미경 ( Mi Kyung Park ),조미라 ( Mi La Cho ),서수홍 ( Soo Hong Seo ),주지현 ( Ji Hyeon Ju ),윤종현 ( Chong Hyeon Yoon ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.2
Objective: To investigate the effect of tumor necrosis factor (TNF)-α on the production of macrophage migration inhibitory factor (MIF), which might have important roles in the immune mediated inflammatory response of Behcet`s syndrome. Methods: Sixty two patients with Behcet`s syndrome and thirty healthy controls were included in this study. The concentrations of TNF-α in sera were determined by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMCs) from eleven patients with Behcet`s syndrome were cultured for 48 hours with various concentration of TNF-α. The concentrations of MIF in sera and culture supernatants were determined by ELISA. Results: Serum levels of TNF-α were significantly higher in patients with Behcet`s syndrome than in healthy controls. TNF-α dose-dependently increased MIF production from PBMCs in patients with Behcet`s syndrome. Serum levels of TNF-α tended to correlate with serum levels of MIF, although did not reach statistical significance. Conclusion: Upregulation of MIF production by increased levels of TNF-α in patients with Behcet`s syndrome might be related to the pathogenesis of Behcet`s syndrome.
염증성 관절염 마우스 모델에서 Sauchinone의 치료 효과
정승민 ( Seung Min Jung ),이재선 ( Jae Seon Lee ),이주현 ( Ju Hyun Lee ),백승예 ( Seung Ye Baek ),박성환 ( Sung Hwan Park ),곽승기 ( Seung Ki Kwok ) 대한류마티스학회 2016 대한류마티스학회지 Vol.23 No.3
Objective. Rheumatoid arthritis (RA) is a chronic inflammatory disease, mainly involving joints and bones. Sauchinone is an anti-inflammatory agent isolated from Saururus chinensis, which was used in oriental medicine. The aim of this study was to evaluate the therapeutic effect of sauchinone on inflammatory arthritis and underlying mechanism of anti-arthritic effect. Methods. Mice with collagen induced arthritis (CIA) was intraperitoneally injected with sauchinone (20 mg/kg) or vehicle. The clinical and histological evaluations were performed with arthritis scoring and hematoxylin-eosin staining, respectively. CD4+ interleukin (IL) 17+ T cells were determined under Th17 skewing condition treated with sauchinone. To evaluate the effect of sauchinone on osteoclastogenesis, mice bone marrow macrophages (BMMs) and human peripheral blood mononuclear cells (PBMCs) were cultured with macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand in the absence or presence of sauchinone. Results. Sauchinone significantly attenuated the inflammatory arthritis in CIA mice both clinically and histologically. The proportion of Th17 cells were decreased with treatment with sauchinone in vivo and in vitro. The expressions of Th17 cell markers (IL-17 and retinoic acid receptor-related orphan receptor gamma t) and B cell markers (activation-induced cytidine deaminase) were downregulated in the presence of sauchinone. Sauchinone also suppressed the formation of tartrate-resistant acid phosphatase positive cells from mice BMMs and human PBMCs, and the expression of osteoclastogenic markers. Conclusion. Sauchinone alleviates inflammatory arthritis in mice through inhibition of Th17 differentiation and osteoclastogenesis. Sauchinone, one of traditional herbal medicine, could be a therapeutic candidate for the treatment of RA. (J Rheum Dis 2016;23:161-173)
전신홍반루푸스에 동반된 항인지질항체 증후군 환자에서 괴저농피증 양상으로 발현된 족부 궤양
허기훈 ( Ki Hoon Hur ),곽승기 ( Seung Ki Kwok ),박윤정 ( Yoon Jung Park ),최진정 ( Jin Jung Choi ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
Antiphospholipid syndrome (APS) is characterized by vascular thrombosis in association with elevated titers of antiphospholipid antibodies. Leg ulcers are a considered to be a cutaneous manifestation of APS due to thrombosis of small to medium sized vessels. We report a case of necrotic non-healing, ankle ulcers mimicking pyoderma gangrenosum associated with APS in 50-year-old man. He had a past history of autoimmune thrombocytopenia and cerebral infarction. Laboratory findings showed a circulating lupus anticoagulant, positive anticardiolipin antibodies as well as anti-dsDNA and anti-Sm antibodies. Skin biopsy of ulcer lesions showed thrombotic vasculopathy of medium sized vessels with minimal leukocyte infiltration. Ulcers were successfully treated with surgical debridement and subsequent skin graft along with anticoagulation therapy.
TNF-α 억제제로 치료중인 연소성 류마티스관절염 환자에게서 발생한 2차성 아밀로이드증
민홍기 ( Hong Ki Min ),윤문희 ( Moon Hee Yoon ),김은오 ( Eun Oh Kim ),김대원 ( Dae Won Kim ),김남용 ( Nam Yong Kim ),곽승기 ( Seung Ki Kwok ),박성환 ( Sung Hwan Park ),김호연 ( Ho Youn Kim ),주지현 ( Ji Hyeon Ju ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.5
Secondary amyloidosis is one of the most serious complications in chronic inflammatory diseases such as rheumatoid arthritis. The extracellular deposit of aggregates of amyloid leads to target organ dysfunction. The mainstay treatment of secondary amyloidosis is the control of underlying disease activity. Many reports have reported that TNF-α inhibitors improve clinical outcomes. Here, we encountered a 34-year-old patient with juvenile rheumatoid arthritis who developed secondary amyloidosis despite treatment with TNF-α inhibitors. We present this case and include a review of the literature.
조병식 ( Byoung Sik Cho ),곽승기 ( Seung Ki Kwok ),서영일 ( Young Il Seo ),민도준 ( Do June Min ),김완욱 ( Wan Uk Kim ),이숙경 ( Suk Kyoung Lee ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Rheumatoid arthritis(RA) is occasionally associated with variable extra-articular involvement and the chronic inflammatory process can affect the gastrointestinal system. The gastrointestinal involvement in RA may present in many causes: drug induced colitis, vasculitis and amyloidosis involved in the gut, association with certain bowel diseases such as collagenous colitis or infectious colitis. Ulcerative colitis(UC) is a chronic inflammatory bowel disease and is commonly associated with peripheral joint disease which correlates with the disease activity and extent of the bowel inflammation. The arthritis is usually presented in pauciarticular, generally asymmetric, transient, and nondestructive pattern. However, the chronic and destructive peripheral arthritis has been reported in a few cases and RA has not been observed in association with UC. We experienced a case of RA patient with recurrent abdominal pain, hematochezia, and tenesmus who was diagnosed as UC by endoscopic and histologic finding. We herein report the case with literature.
부신생물 증후군으로 인한 성인형 스틸병의 임상상을 보인 기관지폐포암
김현진 ( Hyun Jin Kim ),곽승기 ( Seung Ki Kwok ),신정하 ( Jung Ha Shin ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.1
Adult-onset Still`s disease (AOSD) is a systemic inflammatory disorder with the characteristics of high spiking fever, evanescent salmon-colored skin rash, arthralgia or arthritis, lymphadenopathy, hepato-splenomegaly, sore throat, leukocytosis, negative autoantibody and hyperferritinemia. There are reports that rheumatic diseases such as dermatomyositis, polymyositis, hypertrophic osteoarthropathy, and polymyalgia rheumatica are associated with neoplasms. And small cell lung cancer, thymoma, lymphoma, leukemia, and breast cancer are known to be more associated with paraneoplastic syndromes mimicking rheumatic diseases. We experienced a case with bronchioloalveolar carcinoma who developed clinical manifestations of AOSD. Although there are several reports that AOSD is associated with paraneoplastic syndrome, to our knowledge, this is the first case of bronchioloalveolar carcinoma mimicking AOSD reported in the world.