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고홍섭 대한안면통증구강내과학회 1998 Journal of Oral Medicine and Pain Vol.23 No.3
Salivary research is at a critical crossroads regarding the clinical application of the basic knowledge. The purpose of this article is to introduce the current progress on salivary research to Korean dental scientists. The accumulated results based on advance technologies such as protein chemistry, molecular biology, and structural biology have showed that salivary macromolecules need structural requirements for proper function. Currently, several concepts or principles, which can be applied to salivary macromolecules, have been suggested. These include the role of molecules' conformation on biological activity, their multifunctional nature, their redundancy of function, their amphifunctional properties, and the potential importance of complexing between molecules. These concepts and the information available will help the development of saliva substitutes, the design of drug carriers and chimera molecules with enhanced function and the development of gene therapy protocols. These approaches will alleviate or restore lost salivary function and can be used to treat various kinds of oral and systemic diseases.
고홍섭,Kho, Hong-Seop 대한안면통증구강내과학회 1999 Journal of Oral Medicine and Pain Vol.24 No.3
The present investigation was carried out to identify salivary components of mucosal pellicle and to explore the difference of mucosal pellicle components according to the location of oral mucosa. By using antisera and immunoblotting, high-(MG1) and low-(MG2) molecular-mass salivary mucins, amylase, IgA, proline-rich proteins(PRPs) were detected in mucosal pellicle in vivo. In addition, the data indicated that mucins, IgA and proline-rich proteins could be cleaved into lower-molecular-mass products, whereas the IgA, proline-rich proteins could also be cross-linked into higher-molecular-mass complexes. Mucosal pellicles from buccal, labial and palatal mucosa showed similar pattern in immunoblotting experiments using anti-MG2 and anti-PRPs antisera. The data from this study suggest that during mucosal pellicle formation multiple components of saliva adsorb to oral mucosal epithelial cell surfaces, and selected components can be proteolytically cleaved into smaller fragments and/or cross-linked into higher-molecular products.
고홍섭,Kho, Hong-Seop 대한수면의학회 2005 수면·정신생리 Vol.12 No.1
Bruxism is defined as 'diurnal or nocturnal parafunctional activity including clenching, bracing, gnashing, and grinding of the teeth'. Bruxism and clenching are two of the most common contributing factors in patients with temporomandibular disorders and craniofacial pain disorders. Even though many studies report the high prevalence of bruxism, its cause is still not clear. Occlusal interference has been regarded as a major etiologic factor. Nowadays, psychological stress and sleeping disorders are generally regarded as major possible etiologic factors. More than likely, the cause is multifactoral and overlapping, which makes it difficult for the practitioner to apply comprehensive and effective management strategies. Although dentists and psychologists generally believe that effective treatment is best achieved with a better understanding of the etiology of a given disorder, for now treatment for this type of disorder must proceed without a clear understanding of etiology. To overcome this obstacle, evidence-based comprehensive management protocols based on accumulated scientific findings should be provided. In this presentation, epidemiology, etiology, and the characteristics of bruxism are reviewed. Diagnostic procedures and management strategies focused on occlusal appliances and behavioral approaches are also discussed.
고홍섭,Go, Hong-Seop 사단법인 한국당뇨협회 2007 당뇨 Vol.207 No.-
당뇨병환자의 치과시술시 가장 문제가 되는 사항은 감염에 대한 위험성 증가와 창상치유 지연이다. 대부분의 치과치료는 출혈을 일으키고 창상을 남긴다. 만약 치과치료를 예정하고 있는 환자가 당뇨병환자라면 치과의사는 보다 적극적으로 감염 가능성을 예방하거나 줄이고 창상을 최소화하는 방향으로 치과 치료계획을 세울 것이다. 그러므로 당뇨병환자가 치과치료를 받을 때 가장 중요한 사항은 환자 본인의 당뇨 병력을 상세히 치과 진료진에게 알려주는 것이다. 물론 병력은 상세할수록 좋다.
Expression and Purification ofRecombinant Human Salivary Apo-MG2
고홍섭 대한안면통증∙구강내과학회 2002 Journal of Oral Medicine and Pain Vol.27 No.3
인체 타액 mucin 중 저분자량 mucin의 peptide core 인 apo-MG2 를 non-fusion 형태로 발현시키고 신속하게 정제할 수 있는 간편한 방법을 제시하였다. MUC7 cDNA와 pET-3a/Escherichia coli expression system을 이용하여 apo-MG2를 발현한 다음, ammonium sulfate 침전법을 이용하여 분획을 시행하였으며 reverse phase HPLC로 최종 정제를 실시하였다. Apo-MG2의 발현 수준은 매우 낮았으며 재조합 apo-MG2는 SDS-PAGE 상에서 이동이 느리게 나타나 실제 분자량 보다 큰 분자량을 가진 물질처럼 이동하였다. 인체 타액 MG2가 작은 분자량에도 불구하고 mucin의 특성을 보유하고 있음을 고려해 볼 때, 이러한 방법에 의해 발현, 정제된 apo-MG2는 향후 mucin에 대한 구조적-기능적 연구에 활용될 수 있는 의미있는 물질이 될 수 있을 것이다.