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삼귀고의탕 물추출물의 자연살해세포 활성을 통한 항전이효과
고현숙,박문녀,김봉이,윤택준,송효숙,조성윤,이효정,이효정,정수진,이은옥,김성훈,Ko, Hyun-Suk,Park, Moon-Nyeo,Kim, Bong-Lee,Yoon, Taek-Joon,Song, Hyo-Sook,Cho, Sung-Yun,Lee, Hyo-Jung,Lee, Hyo-Jeong,Jeong, Soo-Jin,Lee, Eun-Ok,Kim, Sung-Ho 대한암한의학회 2010 大韓癌韓醫學會誌 Vol.15 No.1
The anti-metastatic activity of water extract of Samguikoeuitang (WSGKE) consisting of Ginseng Radix, Angelicae Radix, Sophora flavescens and Coicis Semenwas examined. Ethanol extract of Samguikoeuitang (ESGKE) showed significant cytotoxicity against colon 26-M3.1 carcinoma cells, while WSGEK did not. However, WSGKE significantly increased the production of IL-6 and IL-12 in thioglycollate-induced macrophages from Balb/c mice, whereas ESGKE did not. WSGKE significantly increased natural killer (NK) cell cytotoxicity against effecter YAC-1 cells in an Effecter cells/Target ratio dependent manner. Also, WSGKE significantly suppressed lung metastasis after i.v. injection of colon26-M3.1 carcinoma cells. Inhibitory effect of WSGKE on lung metastasis totally abolished in NK cells-deficient mice by treatment with anti-asialo GM1 serum. In addition, the combination treatment of cisplatin and WSGKE (100 ${\mu}g$/mouse) prolonged the lifespan of mice inoculated by colon26-M3.1 cell. These findings suggest that WSGKE can inhibit lung metastasis and prolong life span via immunological enhancement as a Biological Response Modifier.
고현숙 ( Hyun Sook Ko ),강경원 ( Kyung Won Kang ),김정희 ( Jung Hye Kim ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
Background:Gleditsin is a herb medicine from extracted by Gleditschia spina. In oder to investigate anticancer effects of gleditsin in human various breast cancer cells, we tested with gleditsin on cytotoxicity of materials, observed to cell survival and cell cycle progression, and analyzed in starvation condition. Materials and Methods:The cytoxicity and cell cycle progression were analyzed in human breast cells, MCF-10A and human breast cancer cell lines, MDA-MB-231, MDA-MB-361, and MDA-MB-435. IC50s of breast cancer cell lines were measured by MTT assay. The cell cycle were showed by flow cytometric analysis in cells treated with gleditsin. We analyzed DNA content of sub-Go/G1 phase, it was detected apoptosis. 1) Results:Cell survivals were decreased in a dose-dependent manner by the treatment of cells with gleditsin. IC50s were 4.11-fold higher in MDA-MB-435, 2.53-fold higher in MDAMB- 231, and 2.55-fold higher in MDA-MB-361 than in normal breast cells. Flow cytometric analysis showed that sub-G0/G1 fractions in cancer cells treated with gleditsin were higher than that normal cells, suggesting that increases in cytotoxicity of cancer cells by gleditsin were resulted from apoptosis. Cell cycle progression was also changed by the treatment of gleditsin. The treatments of gleditsin resulted in a decrease in G1 phase and an increase in G2/M phase in normal breast cells as well as cancer cell lines. Apoptotic cell death was synergistically increased by cell starvation and gleditsin treatments in cancer cells. MDAMB- 435 cells were more sensitive to apoptotic cell death by gleditsin than other cells. Conclusion:An anti-tumor effect of gleditsin was selectively higher in hman breast cancer cells than in normal human breast cells, and was mediated by apoptotic cell death.
Difficulty Levels and Characteristics of TOEFL Listening Items for Korean EFL Learners
고현숙(Hyun Sook Ko) 한국영어어문교육학회 2016 영어어문교육 Vol.22 No.3
The study aims to investigate Korean university students listening achievements in an English proficiency test and suggest several aspects in need to improve in for schools. The researcher examines which TOEFL testing items have high, medium, and low percentages of correct answers, and what characteristics correspond to these groups. 61 Korean university students in a local city in Korea participated in a computer-mediated test. 36 out of the 61 participants also participated in an interview for immediate reflection on what they thought during the test. Descriptive statistics and correlation analyses showed that the students experienced the most difficulty with testing items requiring summarizing of presented information and understanding of relationships among concepts. This interpretation was confirmed by the interview data. We suggest that intensive instructional intervention, including material development and classroom activities, focus more on high level information processing such as summary and integration for Korean EFL university students. Another suggestion was made that EFL listening testing items for the students be developed to include more integrative information processing.