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고익배 한국농화학회 1974 Applied Biological Chemistry (Appl Biol Chem) Vol.17 No.3
In the presence of 2N hydrochloric acid, N-bromosuccinimide reacts with 8-aminoquinoline to yield 5,7-dibromo-8-aminoquinoline in aqueous medium. This reaction proceeds readily and quantitatively at room temperature. The mechanism of this reaction is investigated in this work. A new titrimetric method for the micro-determination of 8-aminoquinoline by the use of N-bromosuccinimide is described. The proposed method is quite simple, rapid and yet shows relatively high accuracy over the suggested range. The experimental error does not exceed ±1.78 per cent. Results are reported for the comparative analysis of 8-aminoquinoline by the proposed method and by bromimetry.
고익배,이용복 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.3
Dissolution characteristics and urinary excreted amount of commercially available three brands of sulfisoxazole tablets were investigated in order to elucidate the in vitro-in vivo correlations and relative bioavailability in humans. All the tablets tested met the K.P. IV and the USP XXI specifications for tablet weight variation, content uniformity, disintegration and dissolution. The disintegration and dissolution rate constants of sulfisoxazole tablets in pH 2.0 HCl-KCl buffer were reduced more significantly (p<0.05) than those in diluted HCl (1→12.5) and pH 6.5 phosphate buffer. It seemed to be attributed to the pH dependent solubility of sulfisoxazole. We could see that the relative bioavailability of brand B to sulfisoxazole powder was about 90% and that its value was higher than those of other two brands from the urinary excretion data obtained from eight healthy male volunteers by means of Latin square cross over design. No useful correlation was observed between the in vitro and in vivo studies in this experment.
난용성 약물의 용출 증가(제4보) -재결정법에 의한 푸로세미드의 미세화-
고익배,신상철,오인준,Koh, Ik-Bae,Shin, Sang-Chul,Oh, In-Joon 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.2
The size of furosemide was reduced by the recrystallization method in order to increase the dissolution rate of the drug. Surfactants or hydrophilic polymers were used to suppress the aggregation in the crystal formation-growth process of microparticles by dispersing action. Dissolution rate of microparticles increased remarkably due to the size reduction of microparticle. The particle size decreased with increasing the concentration of the drug and the dispersing agents, i.e., surfactants or hydrophilic polymers. No polymorphic transition occurred during the microcrystallization process, but the habit of crystal formation was altered in the case of anionic surfactant.
총수담관 결찰에 의한 간외 담즙분비정체가 흰쥐의 간기능에 미치는 영향에 대한 약물속도론적 분석
고익배,이용복,나은영,주은희,정숙진 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.3
In order to examine the effect of extrahepatic cholestasis induced by common bile duct ligation on the hepatic function, the pharmacokinetics of antipyrine and d-propranolol were investigated in rats. In addition, in an attempt to observe the degree of direct hepatic injury, light and electron microscopic observations and conventional pathologic test using serum were performed. Five days after common bile duct ligation, antipyrine(15 ㎎/㎏) and d-propranolol(3 ㎎/㎏) were intravenously administrated to the rats, respectively. The total clearances of antipyrine and d-propranolol were significantly(p<0.05) decreased. Because hepatic clearance of antipyrine poorly extracted by the liver and that of d-propranolol highly extracted by the liver are respectively dependent on the hepatic intrinsic clearance and the hepatic blood flow, it may be concluded that extrahepatic cholestasis following five days after common bile duct ligation decreased the hepatic intrinsic clearance and the hepatic blood flow. SGPT, SGOT, cholesterol, bilirubin(total bilirubin. direct bilirubin) and alkaline phosphatase were significantly increased(p<0.05). The proliferation of bile ducts was prominent, and degeneration and necrosis of hepatocytes were observed by light microscope. Also, ultrastructurally, bile canaliculi were containing the amorphous materials and losing microvilli. and SER and RER in hepatocytes were dilated and vacuolated.