로테프레드놀과 프레드니솔론 점안제가 테논낭 섬유아세포의 증식에 미치는 영향

강선희,김재우,Sun Hee Kang,Jae Woo Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.9

Purpose: To compare the effect of loteprednol etabonate (LE) with prednisolone acetate (PDA) drops on the proliferation of human Tenon’s capsule fibroblasts (HTFBs). Methods: Primarily cultured HTFBs were treated with serially diluted PDA and LE for 3 days. Cellular survival was determined by a rapid colorimetric assay using MTT. RT-PCR was performed to determine the relative expression of TGF-β mRNA in response to LE and PDA. Results: PDA inhibited proliferation of HTCF in a dose-dependent manner and LE inhibited significantly the proliferation of HTCF at the higher concentration of 50 μg/ml (p < 0.05). Compared to LE, PDA inhibited proliferation of HTCF significantly at each diluted concentration (p < 0.05). Expressions of TGF-β were decreased as the concentration of both PDA and LE increased. PDA decreased expression of TGF-β more significantly compared to LE at each concentration (p < 0.05). Conclusions: Although LE has offered promising anti-inflammatory efficacy with decreased impact on intraocular pressure, LE may be less effective than PDA in inhibiting fibroblast proliferation and may be not comparable to PDA in preventing excessive scarring after glaucoma filtering surgery.

전통 유과가공공정의 분석(I): 수침 및 꽈리치기 공정

강선희,류기형,Kang, Sun-Hee,Ryu, Gi-Hyung 한국식품과학회 2002 한국식품과학회지 Vol.34 No.4

유과가공공정의 개선 및 새로운 공정개발을 위하여 전통적인 유과가공공정의 올바른 분석이 중요하다. 전통적인 유과제조 공정에서 많은 시간을 필요로 하는 수침공정과 꽈리치기 공정을 분석하였다. 찹쌀의 수침은 증자만을 고려한다면 $15^{\circ}C$에서 3일 수침으로 충분하였지만 전통유과 특유의 부드러운 조직감은 6일 이상의 수침이 필요하였다. 수침한 찹쌀의 변화를 관찰한 결과 찹쌀 과피층에 존재하는 단백질이 감소하였고 수침한 찹쌀가루의 페이스트점도는 7일 수침한 찹쌀가루가 최대점도를 나타내고 감소하는 경향을 보였다. 수침에 의한 찹쌀 전분의 미세구조를 관찰한 결과 수침공정을 통해 전분표면이 손상되었다. 수침시간의 증가와 함께 유과의 팽화도는 증가하는 경향을 보였다. 꽈리치기에서 수침시간이 증가할수록 기공의 크기는 감소하였으며 균일한 기공의 분포를 나타내었고 반죽에너지 투입량은 감소하였다. 전통유과의 특징인 부드러운 조직감은 수침시간의 조절뿐만 아니라 반죽에너지 투입량의 조절에 의해 조절이 가능할 수 있었다. The analysis of traditional process for a Korean puffed rice snack (Yukwa) is needed to develop an advanced process for Yukwa-making. Steeping and punching (Koarichigi) processes, consume time and labor in Yukwa-making, were analyzed on this study. Steeping of waxy rice at $15^{\circ}C$ for 3 days was required to equilibrate moisture absorption in waxy rice kernel. However, steeping for more than 6 days was required soft texture and small air cell distribution of Yukwa. Protein content at pericarp on endosperm of waxy rice kernel was decreased and starch granule was damaged during steeping. RVA paste viscosity was the highest at 6 day steeping after than decreased. Expansion ratio of Yukwa was increased with the increase in steeping time. Air bubbles in dough after punching were uniformly distributed and kneading energy input was decreased with the increase in steeping time. Soft texture, unique texture of Yukwa could be controlled by controlling steeping time and kneading energy input during punching process.

전통 유과가공공정의 분석(II): 반데기성형, 건조, 수분조절 및 부재료의 첨가

강선희,류기형,Kang, Sun-Hee,Ryu, Gi-Hyung 한국식품과학회 2002 한국식품과학회지 Vol.34 No.5

전통적인 유과제조공정에서 반데기의 성형, 건조, 수분조절과 부재료의 첨가가 유과의 특성에 미치는 영향을 결정하였다. 반데기의 숙성에 따른 반데기의 페이스트 점도는 숙성기간 2일에 최대점도 300 RVU이였고 숙성기간이 길어질수록 최대점도가 감소하였다. 수침을 거친 반데기의 기공은 내부에 균일하게 분포되어 있었으나 숙성기간이 길어짐에 따른 크기와 분포의 변화는 없었다. 전통적인 유과제조 공정으로 제조한 반데기의 최적 수분함량 $14{\sim}17%$에서 튀겼을 때 팽화도와 조직감은 좋았다. 유과원료의 부재료로 대두즙과 소주를 첨가한 찹쌀반죽으로 제조한 반데기를 튀긴 유과의 팽화도와 조직감이 우수하였다. 소주는 유과의 팽화에 영향을 미치고 대두즙은 조직감을 부드럽게 하였다. 유과(유탕팽화 펠릿)의 내부에는 큰 기공이 분포하며 외부에는 작은 기공이 세밀하게 분포되어 있었다. Effects of pelleting, drying, conditioning, and additives on the characteristics of Yukwa (fried pellet) were determined. RVA maximum paste viscosity of Bandegi (waxy rice pellet) was the highest after 2 days of moisture conditioning process, and decreased 2 days later. Air bubbles in Bandegi were distributed uniformly but were not significantly affected by conditioning time. For higher expansion and softer texture of Yukwa, the optimum moisture content of dried and conditioned Bandegi was $14{\sim}17%$. The addition of soymilk and 25% alcohol (Soju) as additives was also effective for achieving higher expansion and soft texture of Yukwa, respectively. Larger air cells were distributed in the center and smaller ones on the edge of Yukwa.

의무기록 완성도에 대한 병동순회 의무기록사제도의 개입효과

강선희,박훈기,이금순,문옥륜,정풍만,Kang, Sunny,Park, Hoon Ki,Lee, Keum Soon,Moon, Ok Ryun,Jung, Poong Man 한국의료질향상학회 1999 한국의료질향상학회지 Vol.6 No.1-2

Background : With the CQI concepts, which emphasize doing the right things right the first time, we tried to enhance the timely completion of medical records by changing the review process from retrospective method to concurrent one. Methods : Against the current retrospective QA activity, Medical record administrator did the concurrent QA of the inpatient medical records with the deficiency sheets. One general surgery ward was chosen as a trial one. The deficiency rate of the medical records of the discharged patients was compared before and after the enforcement of the system. Job analysis of the medical record departments was done about four tertiary care hospitals located in Seoul to estimate the cost and the time consumed by current system. Results : There was a little improvement in the completion rate of the medical records after the trial. The new system was effective. And job analysis showed that much money and time were wasted by current retrospective feedback system. Conclusion : Though the result was not so satisfactory, it should be considered that this test was a voluntary one and the interns and residents were not forced to complete the medical records during this trial period. If there be any strong motivation to complete the medical record in time, this system is sure to be succeed. As the DRG system requires the concurrent review of the medical records to confirm severity of the patient's illness and to assure the timely discharge, it is desirable to enforce this method with the DRG system together. DRG coding and reducing deficiency rate of the medical records can be accomplished simultaneously.

고액진료비 환자의 특성 비교분석 - 의료보험과 의료보호환자를 중심으로 -

강선희,문옥륜,Kang, Sunny,Moon, Ok-Ryun 한국의료질향상학회 1996 한국의료질향상학회지 Vol.2 No.2

Background : A small number of high cost patients usually spend a larger proportion of scarce health resources. Aged, long-term care and readmitted patients usually belong to these high cost patient group. Among others, long length of stay and readmission can be reduced by checking its cause, and these are the areas needed most of quality improvement activity. Characteristics of high cost medical users between health insurance program and medical assistance program were reviewed. Methods : The inpatient claims of health insurance and medical assistance program were analyzed. Patients were divided by 6 groups; long-term, mid-term, short-term, readmitted, cancer and aged. We defined high cost patients as those who had spent one and half million won and over per 6 months. Characteristics of high cost patients for each group were reviewed. Results : medical assistance patients used much more resources than the insured members in the average hospital cost per case but less in daily hospital cost. The former had a longer length of stay and had much heavier diseases. Major diseases of both group were cancer, diseases of circulatory system and chronic degenerative diseases. Gallstone and schizophrenia were more in the insured program. However, pulmonary tuberculosis, asthma were more common among the medical assistance patients. Early readmission before 2 weeks were 28-30% of the total readmission. Readmission rate in the malignat neoplasm and renal failure were 80% and more. Q.A program should be installed to prevent unnecessary readmissions. Conclusion : Almost 30% of early readmissions and admissions due to complications and long length of stay should be reviewed carefully to keep cost down and to enhance the quality of hospital care.

고강도 웨이트 트레이닝이 노인여성의 신체조성과 체력기능수행에 미치는 영향

강선희(Kang, Sun-Hee),한건수(Han, Gun-Soo) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.2

이 연구의 목적은 고강도로 실시되는 12주간의 웨이트 트레이닝을 통하여 노인 여성들의 신체조성 및 기능 적 체력에 어떠한 변화가 있는지를 규명하는 것이다. 연구대상자들은 U경로당에 정기적으로 출입하는 70세 이상 노 인 여성 중에 실험의 취지를 알고 자발적 참여의사를 가진 24명을 선정하였다. 선정된 24명을 무선할당 방법을 통해 두 개의 운동집단인 고강도 저항성 운동 집단 (High intensity resistance group, n=8), 저강도 저항성 운동 집단(Low intensity resistance group, n=8) 그리고 비교군 (Control group, n=8)으로 나누었다. 운동집단은 12주간의 고강도 및 저 강도 저항성 운동을 실시하였으며, 비교군은 12주간 어떠한 운동에도 참가하지 못하도록 제한하였다. 연구결과, 12주 간 실시된 고강도 웨이트 트레이닝은 근력과 민첩성을 유의하게 향상시켰으며, 체지방률과 체지방량은 유의하게 감소 시켰다(p<0.05). 평형성 및 심폐능력은 향상되었으나 통계적 유의성은 없었다. 종합해보면 정기적인 고강도 웨이트 트 레이닝은 노인 여성들의 체력 개선에 도움을 줄 수 있는 운동이라 사료된다. The elderly population has been dramatically increasing over the past years, but most of the population has developed chronic diseases and handicaps due to aging. High-intensity resistance training is one of the most effective ways to improve muscular strength, but it is unclear whether body composition and functional fitness would be increased by high-intensity resistance training. The aim of this investigation was to explore whether 12 weeks of high-intensity training would improve muscular strength, body composition, and functional fitness in women over the age of 70 years. Twenty-four participants were randomly assigned to a high-intensity resistance training group (n=8), a low-intensity resistance training group (n=8), and a control group (n=8). The experimental groups exercised 3 days per week for 12 weeks at a local fitness center. An analysis of variance(ANOVA) with repeated measures was used for analysis. The results showed that there was a significant improvement in agility and muscular strength following the high-intensity resistance training. Moreover, Moreover, %body fat and body fat mass decreased significantly after the 12 weeks of high-intensity resistance training(p<0.05). Based on these results, it was concluded that high-intensity resistance training is efficient for women over the age 70 years in increasing their muscular strength and functional fitness and reducing their total body fat mass.

수침과 반죽시간이 반죽에너지 투입량과 반데기 및 유과의 성질에 미치는 영향

강선희(Sun Hee Kang),이승주(Seung Ju Lee),류기형(Gi Hyung Ryu) 한국산업식품공학회 2001 산업 식품공학 Vol.5 No.1

N/A

비정규근로자에 대한 차별적 처우의 판단기준 -비교대상기준의 선정원리를 중심으로-

강선희 ( Sun Hee Kang ) 안암법학회 2012 안암 법학 Vol.0 No.37

It has been over 4 years since non-discrimination policy towards irregular employees and discrimination correction system came into effect (2007.7). Particularly, it has been only 2 years since the coverage of act gradually expanded to every business of more than five employees by character(public sector) and scale of business according to additional clauses. The effect of Irregular Employee Act(``Irregular Employee Act`` is used as a collective term to refer to Act on the Protection etc., of Fixed-term and Part-time Employees, Act on the Protection etc., of Dispatched Workers) on correction of discrimination and wage disparity is rather unclear at current state. However, irregular employees were offered no more than 54.8% of wage regular employees got in January 2010, which shows further widened gap compared to 62.6% in August 2005. Among discrimination correction cases that National Labor Relations Commission has ruled, 43 cases were dismissed from July 2007 to end of December of 2010. Lack of comparable employees was the major cause of such dismissal(16 cases). In this context, this paper examined the standing and the role of comparable employees in judgerment of discrimination with an emphasis on selection criterion for comparable subjects. This paper also critically looks into rulings of courts and National Labor Relations Commission seeking alternative interpretation and suggests legislative improvement in case interpretation reaches limitation. Especially, non-discrimination provisions on dispatched workers seem to be ineffective in correction of discrimination due to the question of setting a subject of comparison. In regard to dispatched workers, possible amendments were suggested with reference to EU directives and legislations of other countries.

호르몬 수용체와 임상 병리학적 예후인자와의 관계 및 예후

강선희(Sun Hee Kang),정기용(Ki-Yong Cheung),김유사(You-Sah Kim) 대한외과학회 2003 Annals of Surgical Treatment and Research(ASRT) Vol.65 No.3

숙성용기를 달리한 전통 쌀 증류식 소주의 숙성 중 이화학 특성 및 향기성분의 변화

강선희(Sun-Hee Kang),김재호(Jae-Ho Kim),이애란(Ae-Ran Lee),김아라(A-Ra Kim),김태완(Tae-Wan Kim) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.4

전통 쌀 증류식 소주를 제조하여 오크통에 숙성시킴으로써 숙성 중에 증류주의 이화학적 특성 및 향기성분의 변화를 측정하였다. 입국(Aspergillus luchuensis)과 선발된 효모(Saccharomyces cerevisiae Y88-4)로 담금한 발효주를 감압 증류하였다. 제조된 증류주는 오크통과 스테인리스통에 12개월 간 실온 숙성 하였다. 숙성 12개월 후 숙성 전에 비해 MSO (Maturated distilled spirits in Oak)와 MSS (Maturated distilled spirits in stainless) 모두 알코올과 pH가 감소하였고, 산도, 전기전도도는 증가하는 경향을 나타냈다. 손실량, 탁도와 적색도, 황색도, 퓨젤유에서 MSO는 유의적으로 증가하였으나, MSS는 변화가 없었다. 향기성분은 ester류 20종, alcohol 류 7종, acids 류 2종, 기타 5종으로 총 34종의 향기성분이 검출되었다. 12개월 숙성 후 아세트산 에틸, 페닐에틸 알코올이 감소하였고, 카푸릴산 에틸은 증가하여 향기성분에 변화를 나타냈다. 특히 oaklacton과 푸르푸랄은 MSO에서만 검출되어 오크 숙성시 발생하는 특징적인 향기성분으로 사료된다. 전통 쌀 증류주의 오크통 숙성은 알코올 및 손실량은 컸으나, 오크통의 다양한 물질과 반응하면서 색도 및 향기성분이 유의적인 차이를 나타냈다. 이로써 숙성 용기의 선택이 숙성 증류주의 품질에 영향을 미치는 것으로 사료되며, 숙성과정을 통해 다양하고 특색있는 주류제조가 가능할 것으로 기대된다. Maturation of distilled spirit can generate diverse flavors and tastes. Rice Soju was matured in oak casks (MSO) and stainless steel containers (MSS) for one year at ambient temperature. Ipguk (Aspergillus luchuensis) and Saccharomyces cerevisiae Y88-4 were used, and reduced pressure (110±20 Torr) distillation was applied to brew Soju. Acidity and conductivity were increased in both MSO and MSS. MSO reduced alcohol content (from 43 to 40%) and volume (from 18,000 to 12,730 mL), and significantly altered yellowness (from 0.2 to 30.2). Furthermore, MSO increased the isoamyl alcohol (from 276.7 to 339.2 μg/mL) and isobutyl alcohol (from 122.3 to 144.2 μg/mL) content. Gas chromatography-mass spectrometry was used to detect volatile compounds in Soju, which included 20 esters, 7 alcohols, 2 acids, and 5 miscellaneous compounds. Oak lactone was detected only in MSO and was considered as a specific flavor component associated with oak maturation. Thus, maturation materials contribute to the physicochemical property of distilled spirits.