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나노 그레이팅 어레이 구조를 적용한 초고속 다종 검지 프로틴 센서 성형에 관한 연구
조익현(E. Cho),조영걸(Y. Cho),강기원(K. W. Kang),강신일(S. Kang) 한국소성가공학회 2013 한국소성가공학회 학술대회 논문집 Vol.2013 No.5
We demonstrate a mass production method of label-free nanograting structured protein microarrays integrated with micro-well structures for high throughput screening and highly reliable diagnosis. Protein microarray is composed of nanostructured patterns on the bottom of millimeter scale well structures, which can analyze multiple bio-molecular interactions without cross contamination. In this work, a high sensitivity and a high density protein microarray was realized by rigorous coupled wave analysis (RCWA) and micro-well array design. Nanograting patterns integrated with micro-well array were replicated by UV nanoimprinting using a metallic stamp which was fabricated by multi-step LIGA process. Finally, we verified the feasibility of nanograting based protein microarray chip by analyzing the peak wavelength value (PWV) and PWV shift by cTnT and anti-cTnT interactions.