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김영재,김희종,김은화,송은섭,김문중,김귀완,한기옥,류영근,유제윤 대한내과학회 1991 대한내과학회지 Vol.41 No.5
Rifampicin is a widely used drug for the treatment of mycobacterium tuberculosis infections. This drug, among others, is a potent inducer of the hepatic mixed oxygenase enzymes involved in drug metabolism. Therefore, the effects of drugs or hormones metabolized by liver enzymes may be influenced by rifampicin administration. Thus, concurrent treatment of rifampicin and the glucocorticoid hormone can lead to decreased bioavailability of the glucocorticoid hormone and to icreased requirement. With a brief review of the literature, we report a case of rifampicin-induced adrenal crisis, in which the patient received a physiologic maintenance dose of prednisolone and rifampicin.
박상균,이병철,이춘희,김문중,장봉열,한기옥,허기석 대한내과학회 1990 대한내과학회지 Vol.39 No.1
Thrombocytopenia with decreased megakaryocytes is a rare disorder characterized by thrombocytopenia due to a total absence or a marked reduction in the number of bone marrow megkaryocytes. We experienced a case of thrombocytopenia with decreased megakaryocytes in a 15-year-old girl, who was admitted with chief complaints of epistaxis and purpura on the lower extremities. There was a marked decrease of megakaryocytes in the marrow, and only minimal changes in other hematopoietic cell lines were seen. Follow-up studies, including bone marrow aspiration and biopsy which were performed eight months later, revealed typical features of aplastic anemia.