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부교감신경차단제 및 항 Histamine 제의 배합투여가 Salicylamide 의 진통작용에 미치는 효과에 관한 연구
우종학,김신근,김길향,김재완 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1
Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tripelennamine. In the ratio "1 : 1" salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.
우종학 대한약학회 1963 약학회지 Vol.7 No.2,3
In this experiment, it is found that the decomposition reaction of hexamine aqueous solution by heat is the pseudo first order reaction and the calculated decomposition velocity constants of Hexamine aqueous solution are 1.17 * $10^{-5}min.^{-1}(60{\deg}$ C), 1.99 * $10^{-5}min.^{-1}(70{\deg}$ C), 2.35 * $10^{-5}min.^{-1}(80{\deg}$ C), 6.63 * $10^{-5}min.^{-1}(100{\deg}$ C). In the result, the activation energy of decomposition reaction of hexamine aqueous solution is 12 $Cal.mole^{-1}$.
병태동물(病態動物)에서의 약물(藥物)의 Hepatic Clearance에 관한 연구(硏究) I -병태가토(病態家兎)에서의 Bromphenol Blue의 간담수송(肝膽輸送)-
우종학,김신근,이민화,한건,Woo, Chong-Hak,Kim, Shin-Keun,Lee, Min-Hwa,Han, Kun 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.1
Bromphenol blue (BPB) was studied with rabbits in normal and disease states to understand the basic principles of hepato-biliary transport process, and the effect of disease states on the drug disposition. The time course of plasma concentration and of biliary excretion was studied in normal and $CCl_4$ intoxicated rabbits. A conspicuous retention of BPB clearance from the plasma was observed, and the slope of the first-phase of plasma curve was decreased in the intoxicated rabbits. The shape of biliary excretion was same in normal and intoxicated states, but the amount of BPB excreted into bile in the intoxicated states was much smaller than in normal states. A relationship was found which enables one to predict the pattern of uptake of BPB by the liver, and the pattern of excretion into the bile in normal states, but was not in $CCl_4$ intoxicated states. It may be that the application of this experiments would extend the effect of disease states on the drug disposition.
Aspergillus 屬 絲狀菌에서 얻은 耐酸性消化酵素에 關한 硏究
禹鍾鶴,金信根 서울대학교 1970 서울대학교 論文集 Vol.21 No.-
Digestive enzyme preparation like pancreatin and diastase are generally sensitive to gastric juice and their major portion is destroyed on the contact with gastric juice. In oder to obtain acid-stable digestive enzyme, which would fully exhibit its digestive power in gastric juice, approximately 79 strains of Aspergillus sp. were isolated from natureal source, food and crude drugs, sumitted to wheat bran culture, and potency assay was carried out on their culture extract. four of the strains isolated, belonging to Aspergillus sp., had strong proteinolytic activity at pH 3-6.
우종학,김재완 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1
The stability and toxicity test for p. p'-DDT, DDVP and dipterex that put to used sample in this study effects is follows A. about p. p'-DDT ① In elevating the stability of p. p'-DDT, best stabilizing solvent was benzene. ② The stability-agent has no difficulty as long as it not contain metal ion for instance Zn^(2+), Cr^(3+), Al^(3+), and Fe^(2+or3+) but in case of contain Fe^(3+), the combination of salicylaminoguanidine is best effective. ③ Using this product for water-suspension, We must use span 40 for stability agent and adding it at the same time. ④ We must use container which does not week alkali and metal ion but it is to preserved in tight light-resistant container. ⑤ The stopper of container is adapted with above-mentioned condition of container, but it is better not to use metal material. ⑥ This product needs opening ventilation mare than 30 minutes after diffusion or spray and in the room we remove cause of remained poison by cleaning the bottom. B. about DDVP and Dipterex ① Benzene or toluene in best solvent to preserve stability of DDVP and Dipterex. ② Span 40 is superior for stability agent of this product and second is span 80. ③ The pH of solution is very stable in pH 5-6 and comparative stable in alkali more than p, p'-DDT. ④ Container is to preserved in tight, lightresistant container and especially be careful of outflow and inflow of water. ⑤ Because this product is centeral stimulant poison, we must pay attention to prevent cause of contact diadermic toxicity after use.