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부교감신경차단제 및 항 Histamine 제의 배합투여가 Salicylamide 의 진통작용에 미치는 효과에 관한 연구
우종학,김신근,김길향,김재완 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1
Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tripelennamine. In the ratio "1 : 1" salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.
병태동물(病態動物)에서의 약물(藥物)의 Hepatic Clearance에 관한 연구(硏究) I -병태가토(病態家兎)에서의 Bromphenol Blue의 간담수송(肝膽輸送)-
우종학,김신근,이민화,한건,Woo, Chong-Hak,Kim, Shin-Keun,Lee, Min-Hwa,Han, Kun 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.1
Bromphenol blue (BPB) was studied with rabbits in normal and disease states to understand the basic principles of hepato-biliary transport process, and the effect of disease states on the drug disposition. The time course of plasma concentration and of biliary excretion was studied in normal and $CCl_4$ intoxicated rabbits. A conspicuous retention of BPB clearance from the plasma was observed, and the slope of the first-phase of plasma curve was decreased in the intoxicated rabbits. The shape of biliary excretion was same in normal and intoxicated states, but the amount of BPB excreted into bile in the intoxicated states was much smaller than in normal states. A relationship was found which enables one to predict the pattern of uptake of BPB by the liver, and the pattern of excretion into the bile in normal states, but was not in $CCl_4$ intoxicated states. It may be that the application of this experiments would extend the effect of disease states on the drug disposition.
우종학 대한약학회 1963 약학회지 Vol.7 No.2,3
In this experiment, it is found that the decomposition reaction of hexamine aqueous solution by heat is the pseudo first order reaction and the calculated decomposition velocity constants of Hexamine aqueous solution are 1.17 * $10^{-5}min.^{-1}(60{\deg}$ C), 1.99 * $10^{-5}min.^{-1}(70{\deg}$ C), 2.35 * $10^{-5}min.^{-1}(80{\deg}$ C), 6.63 * $10^{-5}min.^{-1}(100{\deg}$ C). In the result, the activation energy of decomposition reaction of hexamine aqueous solution is 12 $Cal.mole^{-1}$.
우종학,김재완 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1
The stability and toxicity test for p. p'-DDT, DDVP and dipterex that put to used sample in this study effects is follows A. about p. p'-DDT ① In elevating the stability of p. p'-DDT, best stabilizing solvent was benzene. ② The stability-agent has no difficulty as long as it not contain metal ion for instance Zn^(2+), Cr^(3+), Al^(3+), and Fe^(2+or3+) but in case of contain Fe^(3+), the combination of salicylaminoguanidine is best effective. ③ Using this product for water-suspension, We must use span 40 for stability agent and adding it at the same time. ④ We must use container which does not week alkali and metal ion but it is to preserved in tight light-resistant container. ⑤ The stopper of container is adapted with above-mentioned condition of container, but it is better not to use metal material. ⑥ This product needs opening ventilation mare than 30 minutes after diffusion or spray and in the room we remove cause of remained poison by cleaning the bottom. B. about DDVP and Dipterex ① Benzene or toluene in best solvent to preserve stability of DDVP and Dipterex. ② Span 40 is superior for stability agent of this product and second is span 80. ③ The pH of solution is very stable in pH 5-6 and comparative stable in alkali more than p, p'-DDT. ④ Container is to preserved in tight, lightresistant container and especially be careful of outflow and inflow of water. ⑤ Because this product is centeral stimulant poison, we must pay attention to prevent cause of contact diadermic toxicity after use.
SEOUL NATIONAL UNIVERSITY AGN MONITORING PROJECT.I. STRATEGY AND SAMPLE
우종학,손동훈,Elena Gallo,Edmund Hodges-Kluck,전이슬,신재진,배현진,조호진,조완진,강다은,Marios Karouzos,김민진,김태우,Huynh Anh N. Le,박대성,박송연,Suvendu Rakshit,성현일 한국천문학회 2019 Journal of The Korean Astronomical Society Vol.52 No.4
While the reverberation mapping technique is the best available method for measuring black hole mass in active galactic nuclei (AGNs) beyond the local volume, this method has been mainly applied to relatively low-to-moderate luminosity AGNs at low redshift. We present the strategy of the Seoul National University AGN Monitoring Project, which aims at measuring the time delay of the Hβ line emission with respect to AGN continuum, using a sample of relatively high luminosity AGNs out to redshift z ∼ 0.5. We present simulated cross correlation results based on a number of mock light curves, in order to optimally determine monitoring duration and cadence. We describe our campaign strategy based on the simulation results and the availability of observing facilities. We present the sample selection, and the properties of the selected 100 AGNs, including the optical luminosity, expected time lag, black hole mass, and Eddington ratio.
우종학,Woo, Jong-Hak 한국천문학회 2010 天文學論叢 Vol.25 No.4
By joining the Giant Magellan Telescope (GMT) project, Korean astronomers will get 10% of the GMT time, starting in the late 2010s. To prepare the GMT era, it is important to evaluate the current observational research activities. We surveyed the research programs performed by domestic astronomers during 2007A - 2010A period, using optical/near - IR telescopes with a medium to large aperture mirror (larger than 4 m). We describe the method and criteria of the survey, and present the results of the analysis based on the collected data.
Misclassified Type 1 AGNs in the Local Universe
우종학,김지강,박대성,배현진,김재혁,이승언,김상철,권홍진 한국천문학회 2014 Journal of The Korean Astronomical Society Vol.47 No.5
We search for misclassified type 1 AGNs among type 2 AGNs identified with emission line flux ratios, and investigate the properties of the sample. Using 4 113 local type 2 AGNs at 0.02<z<0.05 selected from Sloan Digital Sky Survey Data Release 7, we detected a broad component of the Hα line with a Full-Width at Half-Maximum (FWHM) ranging from 1 700 to 19 090 kms-1 for 142 objects, based on the spectral decomposition and visual inspection. The fraction of the misclassified type 1 AGNs among type 2 AGN sample is ~3.5%, implying that a large number of missing type 1 AGN population may exist. The misclassified type 1 AGNs have relatively low luminosity with a mean broad Hα luminosity, log LHα = 40.50±0.35 ergs-1, while black hole mass of the sample is comparable to that of the local black hole population, with a mean black hole mass, log MBH = 6.94±0.51 M⊙. The mean Eddington ratio of the sample is log Lbol/LEdd = -2.00±0.40, indicating that black hole activity is relatively weak, hence, AGN continuum is too weak to change the host galaxy color. We find that the OIII lines show significant velocity offsets, presumably due to outflows in the narrow-line region, while the velocity offset of the narrow component of the Hα line is not prominent, consistent with the ionized gas kinematics of general type 1 AGN population.