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Vasopressin의 血壓上昇效果에 影響을 미치는 諸要因
洪起芳,曺景宇 전북대학교 의과학연구소 1981 全北醫大論文集 Vol.5 No.2
Vascular reactivity and so pressure response can be changed in some different conditions to the same agonist. In this experiment, pressor responses in the several different conditions of the arginine vasopressin was investigated. 1. Arginine vasopressin increased the pressor response in the doses of 1, 3, 10, 30, 100, 300mu/kg, iv, and showed dose response curve. 2. Acute infusion of hypotonic solution under alochol nesthesia showed accentuated respo-nses to the same ranges of ADH over control. 3. Unilateral nephietomy or chronic saline ingestion elicite accentuated responses. 4. Pressor responses to arginine vasopressin were not changed in the adrenalectomized, 0.9% NaCL ingested, hydrocortisone treated rat compared to its responsible control rats. These data suggest the pressor resporses to arginine vasopressin could be changed in certain conditions.
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측뇌실내로 투여한 Thiopental Sodium의 가토 신장기능에 미치는 영향
홍기방,조경우,Hong, Ki B.,Cho, Kyung W. 대한생리학회 1985 대한생리학회지 Vol.19 No.1
One of most frequently used anesthetic agents is barbiturate derivatives. Pentobarbital or thiopental sodium have been used most frequently in the laboratory or clinical practice. There have been reports on the renal effects of barbiturate anesthesia in human and laboartory animals. Renal effects of thiopental sodium anesthesia, however, are still controversial. One of the discrepancies may be derived from the doses used. It has been reported that subanesthetic small dose of thiopental sodium influences the renal function directly. To clarify possible central effects of very small amounts of thiopental sodium on the renal function, experiments have been done in conscious rabbits. Thiopental sodium was infused into the lateral cerebroventricle for 10 minutes. Intracerebroventricular thiopental sodium induced increased urinary volume, glomerular filtration rate and renal plasma flow by doses of $0.1{\sim}1.0\;mg/10 min/rabbit$. Filtration fractions were not changed. Sodium, chloride and potassium excretions were increased by 0.065 mg/10 min/rabbit of thiopental sodium without significant changes of renal hemodynamics. Higher doses of thiopental sodium $(0.1{\sim}1.0\;mg/10 min/rabbit)$ induced greater increases of electrolytes excretion and renal hemodynamics. Free water clearance was not changed by thiopental sodium, but the fractional excretion of free water showed a tendency of decrease. Fractional excretion of sodium was increased by doses of 0.065 to 1.0 mg of thiopental sodium . Highly significant correlation between the changes of glomerular filtration rate and the changes of sodium excretion were found in the higher doses. Plasma renin concentration (activity) was not changed by the centrally administered thiopental sodium. Intravenous thiopental sodium, 1.0 mg/rabbit, induced no changes of renal function in conscious rabbit. These data suggest that intracerebroyentricular thiopental sodium can increase urinary sodium excretion directly by inhibition of sodium reabsorption in the renal tubules and/or indirectly by increasing the renal hemodynamics.
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洪起芳 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1
Author analized 4662 cases of ECG requested from each department from Nov. 1978 toc Oct. 1979 in Jeonbug National University Hospital. The results were as the followings. 1.Total numbers were 4662 cases. : The results requested from each department were 2645 cases(56.7%) of internal medicine, 674 cases(14.5%) of gerneral surgery, 499 cases(10.7%) of orthopedic surgery, 242 cases(5.2%) of neurosurgery, 244 cases(5.2%) of intensive care unit, 95 cases(2.0%) of emergency room, 101 cases(2.2%) of obstetrics and gynecology and 162 cases(3.5%) of others respectively. 2.In total cases, abnormal ECG was 1241 cases, which were composed of 770 cases(62%) of internal medicine, 173 cases(13.9%) of gerneral surgery, 87 cases(7.0%) of orthopedic surgery, 44 cases(3.5%) of neurosurgery, 77 cases(6.2%) of intensive care unit, 52 cases(2.3%) of emergency room, 9 cases(0.7%) of obsterics and gynecology and 29 cases(2.3%) of others respectively. 3.In total abonrmal ECG, age ratio before and after 4th decade was 32% and 68% respectively. In abnormal ECG ratio for total requested cases, ages before and after 4th decaed were 20.6% and 30.9% respectively. 4.In abnormal ECG findings, 397 cases(32.%) of left ventcular hypertrophy, 212 cases(17.1%) of myocardial ischemia, 516 cases(41.6%) of arrhythmia and 116 cases(9.3%) of others were noted.
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洪起芳 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-
Authors reports a case of pulmonary paragonimiasis combined with exudative pleurisy and cerebral paragonimiasis for the first time in Korea. This case a very rare disease characterised by one side motor and sensory paralysis, exudative pleurisy and pulmonary infiltration by paragonimus westermani. The patient was 49 years old man who entered to Jeonbug national university hospital with the chief complaints of much cough and dyspnea associated with complete motor and sensory paralysis of the left half body. Chest-X-ray showed both lower lobe ifiltration with moderate effusion in the right side chast. Routine labolatory examminations including CBC, urine, AFB and parago ova in the sputum, skin test on parago antigen and chemical examminations of blood, pleural fluid and nophilia in eripheral blood and pleural fluid, and positive findings in parago skin test. In rous ova of paragonimus westemani were found. Pleural biopsy was done and the section disclosed diffuse fibrosis and chronic inflammatory cell infiltration. Cerbral angiography and simple skull X-ray ere within normal limits. Almost complete recovery of motor and sensory paralysis of extremity, exudative pleural effusion and pummonary infiltration by only Bithionol administration had gained on 50th hospital day.
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全北地方의 內科患者에 對한 比較評價 : 20個月間 1,722例의 分析 An analysis of transfered cases
安得洙,洪起芳 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-
"The diagnosis is an art" Hippocrates said. For correct diagnosis, sufficient medical know-ledge, medical jugement, alertness and throughtfulness of physicians as well as diagnostic facilities are required. In the present study, an analysis of 1772 patientsadmitted to medical ward for 20 months from Jan. From 1977 to Aug. 1978 at Jeonbug national university hospital was done. The datas were obtained from a review of operative findings together with tissue biopsy of surgical specimen as compared to clinical diagnosis. The results were as follows : 1. Among 1772 patients, 60 cases(3.5%) was transferred to surgical department. 2. Misdiagnosis was noted in 10 cases out of 60 transferred patients, with diagnostic error of 16.7%. 3. Favorable results in transferred patients was obtained in 61%. 4. Malignant disease in transferred patients was 16.6%. 5. Total numbers of medical ward patients during 20 months were 1722 and also sex ratio of male female was 3:2. 6. The season were concentrated somewhat in early spring(March and April), hot summer(July, August, & September), and Winter(December). 7. The kinds of patients showed gastrointestinal disease(26%), infectious disease(22%), drug intoxication including pharmaceutial drug(16%), cerebrovascular disease(10%), cardiovascular cisease(9%), respiratory disease(7%), nephrologic disease(4%), hematologic disease(3%), and endocrinologic disease(3%)
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安得洙,洪起芳 전북대학교 의과학연구소 1978 全北醫大論文集 Vol.2 No.-
We observed following results in 84 patients of cascade stomach in the Department of Internal Medicine, Jeonbug National University Hospital from January to December of 1977. 1. Pure forms were 45 cases(53.6%), organic forms 22 cases(26.2%), and undifferenciated forms 17 cases(20.2%). Men were 61 cases(72.6%) and women 23 cases(27.4%). 2. In the pure form, patients with mild deformity were 25 cases(37.3%), patients with moderate deformity 15 cases(22.4%), and patients with severe deformity 5 cases(7.5%). In organic form, patients with mild deformity were 9 cases (13.4%), moderate 11 cases(16.4%), and severe 2cases (3%). And as a whole, mild deformity was 34 cases(50.7%) moderate 26 cases(38.8), and severe 7 cases(10.5%). 3. In pure form, the mean free acidity of patients with mild deformity was 43.9+16.1mEq/L, moderate 24.9±9.4mEq/L, and severe 5.8±5.8mEq/L, We observed decreasing tendency of free acidity in accordance with the severity of cascade deformity during the fasting state. 4. In organic form, mean free acidity of mile deformty was 53.8±23.3mEq/L, moderate 50.0mEq/L, and severe 68.6±12.0mEq/L. This results suggest that the acidity in organic form is not related to the severity of deformity and also almost all cases of organic forms combined duodenal ulcer with bulb deformity. 5. The most common symptoms of cascade stomach were abdominal pain, epigastric discomfort epigastric fullness, and belching. About 95 percents of symptom was developed within 2houres after meal. 6. Neurotic symptoms such as hot flushing, headache and palpitation were observed in 44% of all cases. 7. In 7 cases, the symptoms were relieved by changing position of body.
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