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Radiation Biology in Space; DNA Damage and Biological Effects of Space Radiation
Ohnishi, Takeo,Takahashi, Akihisa,Ohnishi, Ken Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.3
Astronauts are constantly exposed to space radiation at a low-dose rate during long-tenn stays in space. Therefore, it is important to determine correctly the biological effects of space radiation on human health. Space radiations contain various kinds of different energy particles, especially high linear energy transfer (LET) particles. Therefore, we have to study the relative biological effectiveness (RBE) of space radiation under microgravity environment which may change RBE from a stress for cells. Furthermore, the research about space radiation might give us useful information about birth and evolution of life on the earth. We also can realize the importance of preventing the ozone layer from depletion by use of exposure equipment to sunlight at International Space Station (ISS).
Taigo Inada,Takeo Furuya,Koshiro Kamiya,Mitsutoshi Ota,Satoshi Maki,Takane Suzuki,Kazuhisa Takahashi,Masashi Yamazaki,Masaaki Aramomi,Chikato Mannoji,Masao Koda 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.4
Study Design: Retrospective case series. Purpose: To elucidate the impact of postoperative occiput–C2 (O–C2) angle change on subaxial cervical alignment. Overview of Literature: In the case of occipito–upper cervical fixation surgery, it is recommended that the O–C2 angle should be set larger than the preoperative value postoperatively. Methods: The present study included 17 patients who underwent occipito–upper cervical spine (above C4) posterior fixation surgery for atlantoaxial subluxation of various etiologies. Plain lateral cervical radiographs in a neutral position at standing were obtained and the O–C2 angle and subaxial lordosis angle (the angle between the endplates of the lowest instrumented vertebra (LIV) and C7 vertebrae) were measured preoperatively and postoperatively soon after surgery and ambulation and at the final follow-up visit. Results: There was a significant negative correlation between the average postoperative alteration of O–C2 angle (DO–C2) and the average postoperative alteration of subaxial lordosis angle (Dsubaxial lordosis angle) (r =–0.47, p =0.03). Conclusions: There was a negative correlation between DO–C2 and Dsubaxial lordosis angles. This suggests that decrease of midto lower-cervical lordosis acts as a compensatory mechanism for lordotic correction between the occiput and C2. In occipito-cervical fusion surgery, care must be taken to avoid excessive O–C2 angle correction because it might induce mid-to-lower cervical compensatory decrease of lordosis.
Kim, Jin C.,Takahashi, Keiichi,Yu, Chang S.,Kim, Hee C.,Kim, Tae W.,Ryu, Min H.,Kim, Jong H.,Mori, Takeo Lippincott Williams Wilkins, Inc. 2007 Annals of surgery Vol.246 No.5
OBJECTIVE:: To evaluate comparative outcome between adjuvant postoperative chemoradiotherapy (postoperative CRT) and lateral pelvic lymph node dissection (LPLD) following total mesorectal excision (TME) in rectal cancer patients. BACKGROUND:: Although TME results in lower rate of locoregional recurrence compared with conventional surgery, these 2 treatment modalities following TME have not adequately been appraised until the present trend of preoperative chemoradiotherapy. PATIENTS AND METHODS:: Between 1995 and 2000, patients with stage II and III rectal cancer underwent TME plus postoperative CRT (n = 309) or LPLD (n = 176). Patients in the postoperative CRT group received 8 cycles of 5-fluorouracil plus leucovorin and 45 Gy pelvic radiotherapy. Patients in the LPLD group underwent lateral lymph node dissection outside the pelvic plexus. RESULTS:: The 5-year overall and disease-free survival rates were 78.3% and 67.3% in the postoperative CRT group, respectively, and 73.9% and 68.6% in the LPLD group, respectively, without significant differences between these groups. Patients in the LPLD group with stage III lower rectal cancer had a locoregional recurrence rate 2.2-fold greater than those in the postoperative CRT group (16.7% vs. 7.5%, P = 0.044). Multivariate analysis showed that APR and advanced T-category (T4) were significantly associated with locoregional recurrence, whereas lymph node metastases, high preoperative serum carcinoembryonic antigen, and APR were significantly associated with shortening of disease-free survival. CONCLUSIONS:: Postoperative-CRT and LPLD following TME resulted in comparable survival rates, but the locoregional recurrence rate was higher in the LPLD group. These findings suggest that initial surgery is appropriate for rectal cancer patients who are candidates for low anterior resection without extensive local disease (T1–T3), regardless of lymph node status.