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Zhou, Zhi-Xiang,Li, Dan,Guan, Shan-Shan,Zhao, Chen,Li, Ze-Lin,Zeng, Yi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Cervical cancer is the second most common cause of cancer related death of women. Persistent HPV infection, especially with high-risk types such as HPV16 and HPV18, has been identified to be the primary cause of cervical cancer. E6 and E7 are the major oncoproteins of high-risk HPVs, which are expressed exclusively in HPV infected tissues, and thereby represent ideal therapeutic targets for immunotherapy of cervical cancer. Materials and Methods: In this work, we used recombinant adenovirus expressing coden-optimized HPV16 E6 and E7 fusion protein (Ad-ofE6E7) to prime dendritic cells (DC-ofE6E7), to investigate the ability of primed DC vaccine in eliciting antitumor immunity in vitro and vivo. Results: Our results indicated that DC-ofE6E7 vaccine co-culturing with splenocytes could strongly induce a tumor-specific cytotoxic T lymphocyte (CTL) response and kill the TC-1 cells effectively in vitro. Moreover, DC-ofE6E7 vaccine induced protective immunity against the challenge of TC-1 cancer cells in vivo. Conclusions: The results suggested that the HPV16 ofE6E7 primed DC vaccine has potential application for cervical cancer immunotherapy.
장기간의 크레아틴 섭취가 역도선수 신장 기능에 미치는 영향
선주상 ( Zhou Xiang Shan ),안효작 ( Hyo Jak Ahn ),염동철 ( Dong Cheol Yeom ),김창근 ( Chang Keun Kim ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.31 No.1
The aim of the present study was to investigate the effect of a long term creatine supplementation on renal function in weight lifters. Fifty seven weight lifters who have been supplemented creatine was participated in the experiment, and divided into four groups of under 1 yr (n=10), 1 to 3 yrs (n=15), 3 to 5 yrs (n=16), and over 5 yrs (n=16) by the period of creatine intake. Serum and urine creatine, creatinine, uric acid, and cystatin-C were analysed to evaluate renal function. There was no significant differences among the groups, not only by the measurement of serum creatine, creatinine, uric acid, cystatin- C, but also in urine as well. All measured valuables to evaluate renal function maintained normal concentration either in blood or in urine. But urine creatinine and uric acid level were maintained higher than normal concentration, and GFR level in serum was lower than normal level in all groups. In summary, there were no difference among the different durations of creatine supplementation of under one year to more than five years in the parameters measured in serum and urine. However urine creatinine and uric acid level were maintained slightly higher, and GFR level in serum was slightly lower in all groups. Therefore, it is highly recommended further research to confirm these findings in the future.
Application of Highly Charged PAC and Polyamine admixture in Neutral Papermaking
YANYONG-XIANG,CHEN FU-SHAN,WANGLI-JUN,ZHOU LIN-JIE 한국펄프·종이공학회 2006 한국펄프종이학회 기타 간행물 Vol.- No.-
Studied that the relationship between the charge density of PAC and its alkalinity, as well as the influences of PAC in paper sizing. Study results showed that PAC with higher charge density brought higher sizing degree when the same amount of Al₂O₃ content was dosed. However, there was no direct relationship between PAC charge density and its alkalinity, and higher PAC alkalinity can’t improve its charge density. It was also found that the admixture (PPAC) of polyamine and PAC had higher charge density than PAC. The effects of PPAC on DRS and RAKD sizing were better than PAC sizing, when dosage and other sizing condition were the same.
Meta-analysis of Gene Expression Data Identifies Causal Genes for Prostate Cancer
Wang, Xiang-Yang,Hao, Jian-Wei,Zhou, Rui-Jin,Zhang, Xiang-Sheng,Yan, Tian-Zhong,Ding, De-Gang,Shan, Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.
賈春華,周春祥,王天山,崔 勳 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.5
Nae-Kyung says the puberty is corresponded to the age of 16∼24(male) and 14∼21(female). And that time they are promoted the growth. However, Kidney qi (賢氣) doesn't make average situation during that time. So, the function of five viscera and six entrails fails to be perfect and symptoms appear. I came to the conclusion through the survey of about 200 high school students(male and female) and the theory of oriental medicine the distinctive features (like migraine, amnesia, depression, dysphoria, inappetence, irregular menstruation) came out that time. I defined this distinctive symptoms in boys and girls at puberty 'synthetic symptoms of puberty'. For the medical cure and prevention I prescribed 'Sachun-Nyung' and that has medical benefits for 'Replenishing qi and relieving the spleen(益氣養陰), Soothing the liver and promoting blood circulation(疏肝活血)'
( Yue Qun Wang ),( Xiang Li Ye ),( Jun Mei Zhou ),( Yong Qi Wan ),( Hua Ping Xie ),( Yun Deng ),( Yan Yan ),( Yong Qing Li ),( Xiong Wei Fan ),( Wu Zhou Yuan ),( Xiao Yang Mo ),( Xiu Shan Wu ) 생화학분자생물학회 2011 BMB Reports Vol.44 No.1
Zinc finger (ZNF) proteins play a critical role in cell growth, proliferation, apoptosis, and intracellular signal transduction. In this paper, we cloned and characterized a novel human KRAB-related zinc finger gene, ZNF425, which encodes a protein of 752 amino acids. ZNF425 is strongly expressed in the three month old human embryos and then is almost undetectable in six month old embryos and in adult tissues. An EGFP-ZNF425 fusion protein can be found in both the nucleus and the cytoplasm. ZNF425 appears to act as a transcription repressor. Over-expression of ZNF425 inhibits the transcriptional activities of SRE, AP-1, and SRF. Deletion analysis indicates that the C2H2 domain is the main region responsible for the repression. Our results suggest that the ZNF425 gene is a new transcriptional inhibitor that functions in the MAPK signaling pathway. [BMB reports 2011; 44(1): 58-63]
권혁용 ( He Long Quan ),선주상 ( Zhou Xiang Shan ),김영선 ( Young Seon Kim ),최재근 ( Jae Keun Choi ),김창근 ( Chang Keun Kim ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.31 No.1
Hypoxic environment can be defined as a complex phenomenon with a decreased partial pressure of oxygenunder the 150mmHg during inhalation by a decreased atmospheric pressure. A various investigations which is related to a decrease oxygen tension or altitude environment has been performed in the field of life science. It has been intensively studied the relationship between hypoxia and exercise performance to prepare for Mexico Olympic Games, and ahs been performed many studies about the adaptation to hypoxia to prove the possibility of improvement of exercise performance. In recent years athletes who has been training from young age at a mild altitude (2000-3000m a.s.l.) has been leading international competitions of middle and long distance run, including marathon run. However, there has been debated whether altitude environment can modulate bodily function, especially exercise performance. Up to today various attempts has been considered to acclimatize to hypoxia efficiently, because athletes may not perform their maximal capacity during early stage of altitude adaptation, and thus recently new technique has developed to control oxygen content at sea level, in terms of normobaric hypoxia. Hypoxic facility can allow the athletes living in normobaric hypoxia and training in normobaric normoxic environment. Various investigations has been performed not only regarding on exercise performance but also on metabolic syndromes according to different response body function to hypoxia compared to normoxia, especially hypoxia has an important role in glucose and fat metabolism. Hypoxia and exercise induce to increase insulin sensitivity and epinephrine to decrease in muscle glycogen, and also does an increase in the expression of hypoxia-inducible factor-1a and leptin concentration to reduce body weight in voluntarily. Therefore, it is important to unravel the mechanism of body weight reduction by the exposure in hypoxic environment and thus may be suggested as a possible countermeasure to the obesity epidemics. Therefore, hypoxia and its related recent studies of exercise performance and metabolic syndromes, including obesity, glucose and fat metabolism will be included in this review.
ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway
( Yue Qun Wang ),( Jun Mei Zhou ),( Xiang Li Ye ),( Yong Qi Wan ),( Yong Qing Li ),( Xiao Yan Mo ),( Wu Zhou Yuan ),( Yan Yan ),( Na Luo ),( Ze Qun Wang ),( Xiong Wei Fan ),( Yun Deng ),( Xiu Shan Wu 생화학분자생물학회 2010 BMB Reports Vol.43 No.3
Zinc finger-containing transcription factors are the largest single family of transcriptional regulators in mammals, which play an essential role in cell differentiation, cell proliferation, apoptosis, and neoplastic transformation. Here we have cloned a novel KRAB-related zinc finger gene, ZNF424, encoding a protein of 555aa. ZNF424 gene consisted of 4 exons and 3 introns, and mapped to chromosome 19p13.3. ZNF424 gene was ubiquitously expressed in human embryo tissues by Northern blot analysis. ZNF424 is conserved across species in evolution. Using a GFP-labeled ZNF424 protein, we demonstrate that ZNF424 localizes mostly in the nucleus. Transcriptional activity assays shows ZNF424 suppresses transcriptional activity of L8G5-luciferase. Overexpression of ZNF424 in HEK- 293 cells inhibited the transcriptional activity of NFAT and p21, which may be silenced by siRNA. The results suggest that ZNF424 protein may act as a transcriptional repressor that suppresses NFAT and p21 pathway to mediate cellular functions. [BMB reports 2010; 43(3): 212-218]