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Influence of Semi-active Suspension on Running Safety of Vehicles
Hong-You Liu,Da-Lian Yu 한국철도학회 2010 International Journal of Railway Vol.3 No.2
Railway vehicles equipped with semi-active suspension system can improve the ride quality of car bodies. Semi-active suspension system is usually applied onto high speed train, and therefore higher running safety requirement is desirable. The influence of semi-active suspension system on safety of vehicles running on straight line and curve line is studied, and the influences of sky hook damping coefficient and system time-delay on operational safety of cars fitted with semiactive suspension system is analyzed. The results show that in vehicles equipped with semi-active suspension system, while the vibration of car body is decreased, the running safety of cars is not affected to any significant degree. As a result, the ride quality is much improved with negligible deterioration of the running safety of cars.
Influence of Semi-Active Suspension on Running Safety of Vehicles
Liu Hong-You,Yu Da-Lian 한국철도학회 2009 International Journal of Railway Vol.2 No.4
Railway vehicles equipped with semi-active suspension system can improve the ride quality of car bodies. Semi-active suspension system is usually applied onto high speed train, and therefore higher running safety requirement is proposed. The influence of semi-active suspension system on safety of vehicles running on straight line and curve line is studied, and the influences of sky hook damping coefficient and system time-delay on operation safety of cars fitted with semiactive suspension system is analyzed. The results show that the vehicles equipped with semi-active suspension system, not only the vibration of car body is decreased, it can also give little influence on running safety of cars, as a result, it will not endanger the running safety of cars.
Influence of Semi-active Suspension on Running Safety of Vehicles
Liu, Hong-You,Yu, Da-Lian The Korean Society for Railway 2010 International Journal of Railway Vol.3 No.2
Railway vehicles equipped with semi-active suspension system can improve the ride quality of car bodies. Semi-active suspension system is usually applied onto high speed train, and therefore higher running safety requirement is desirable. The influence of semi-active suspension system on safety of vehicles running on straight line and curve line is studied, and the influences of sky hook damping coefficient and system time-delay on operational safety of cars fitted with semiactive suspension system is analyzed. The results show that in vehicles equipped with semi-active suspension system, while the vibration of car body is decreased, the running safety of cars is not affected to any significant degree. As a result, the ride quality is much improved with negligible deterioration of the running safety of cars.
Novel HMW glutenin genes from Aegilops tauschii and their unique structures
Wen-Jie Chen,Zhong-Wei Yuan,Lian-Quan Zhang,Xing Fan,Ze-Hong Yan,Ji-Rui Wang,You-Liang Zheng,Huai-Gang Zhang,Deng-Cai Liu 한국유전학회 2012 Genes & Genomics Vol.34 No.3
A pair of novel high-molecular-weight glutenin subunits (HMW-GS) 1Dx5.3t and 1Dy12.1**t were revealed and characterized from Ae. tauschii accession PI554324. SDS-PAGE band of 1Dx5.3t was between those of 1Bx6 and 1Bx7, while 1Dy12.1**t with slightly faster migration rate than that of 1Dy12. The lengths of 1Dx5.3t and 1Dy12.1**t were 2115 bp and 1986 bp, encoding 703 and 660 amino acid residues,respectively. Their authenticity was confirmed by successful expression of the coding regions in Escherichia coli. 1Dx5.3t is the shortest of the known Dx-type alleles. 1Dy12.1**t is also a special subunit since it has an additional cysteine in the front of the central repetitive domain. This cysteine that is not existed in previously reported Dy-type genes may be useful for improving bread wheat quality. Median-joining Network analysis indicated that 1Dy12.1**t may be a key site in the genealogy of the Glu-Dy.
Ying Yang,Dong Wang,Lei Cui,Hong-Hao Ma,Li Zhang,Hong-Yun Lian,Qing Zhang,Xiao-Xi Zhao,Li-Ping Zhang,Yun-Ze Zhao,Na Li,Tian-You Wang,Zhi-Gang Li,Rui Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1
Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with BRAFV600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A retrospective analysis was performed on 20 children with BRAFV600E-mutated LCH who were treated with dabrafenib. Results The median age at which the patients started taking dabrafenib was 2.3 years old (range, 0.6 to 6.5 years). The ratio of boys to girls was 2.3:1. The median follow-up time was 30.8 months (range, 18.9 to 43.6 months). There were 14 patients (70%) in the risk organ (RO)+ group and six patients (30%) in the RO– group. All patients were initially treated with traditional chemotherapy and then shifted to targeted therapy due to poor control of LCH or intolerance to chemotherapy. The overall objective response rate and the overall disease control rate were 65% and 75%, respectively. During treatment, circulating levels of cell-free BRAFV600E (cfBRAFV600E) became negative in 60% of the patients within a median period of 3.0 months (range, 1.0 to 9.0 months). Grade 2 or 3 adverse effects occurred in five patients. Conclusion Some children with BRAFV600E-mutated LCH may benefit from monotherapy with dabrafenib, especially high-risk patients with concomitant hemophagocytic lymphohistiocytosis and intolerance to chemotherapy. The safety of dabrafenib is notable. A prospective study with a larger sample size is required to determine the optimal dosage and treatment duration.