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이강원,노영진,Wei Gao,Yoshikazu Arai,Yuki Shimizu,Katsutoshi Tanaka,Masahiko Fukuta,Yoshiaki Kai 한국정밀공학회 2011 International Journal of Precision Engineering and Vol. No.
This paper presents the experimental results of investigating the performances of an air-bearing displacement sensor for surface form measurement of micro-structures, such as micro-lenses, on an ultra-precision machine tool. The sensor consists of a stylus for contacting the surface, a shaft for mounting the stylus, an air-bearing for suspending the shaft and a blade spring for applying the measuring force against the surface. At first, experiments were conducted on a vibration isolated table to identify the basic performance of the sensor for displacement measurement. Then, the sensor was mounted on a diamond turning machine for evaluating the performance of the sensor for on-machine surface form measurement of micro-lenses. A roll workpiece, on which a micro-lens array was fabricated by using a fast tool servo on the diamond turning machine, was employed as the specimen for the on-machine experiment of surface profile measurement.
Combination of a SARS-CoV-2 IgG Assay and RT-PCR for Improved COVID-19 Diagnosis
Aoki Kotaro,Takai Kunitomo,Nagasawa Tatsuya,Kashiwagi Katsuhito,Mori Nobuaki,Matsubayashi Keiji,Satake Masahiro,Tanaka Ippei,Kodama Nanae,Shimodaira Takahiro,Ishii Yoshikazu,Miyazaki Taito,Ishii Toshi 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.6
Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is generally diagnosed by reverse transcription (RT)-PCR or serological assays. The SARS-CoV-2 viral load decreases a few days after symptom onset. Thus, the RT-PCR sensitivity peaks at three days after symptom onset (approximately 80%). We evaluated the performance of the ARCHITECT® SARS-CoV-2 IgG assay (henceforth termed IgG assay; Abbott Laboratories, Lake County, IL, USA), and the combination of RT-PCR and the IgG assay for COVID-19 diagnosis. Methods: In this retrospective study, 206 samples from 70 COVID-19 cases at two hospitals in Tokyo that were positive using RT-PCR were used to analyze the diagnostic sensitivity. RT-PCR-negative (N=166), COVID-19-unrelated (N=418), and Japanese Red Cross Society (N=100) samples were used to evaluate specificity. Results: Sensitivity increased daily after symptom onset and exceeded 84.4% after 10 days. Specificity ranged from 98.2% to 100% for samples from the three case groups. Seroconversion was confirmed from 9 to 20 days after symptom onset in 18 out of 32 COVID-19 cases with multiple samples and from another case with a positive result in the IgG assay for the first available sample. Conclusions: The combination of RT-PCR and IgG assay improves the robustness of laboratory diagnostics by compensating for the limitations of each method.