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Lee, Yonggu,Park, Hwan-Cheol,Shin, Jeong-Hun,Lim, Young-Hyo,Shin, Jinho,Park, Jin-Kyu Elsevier 2019 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.277 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Inflammation has been reported to cause atrial fibrillation (AF). However, it remains unclear whether C-reactive protein (CRP) levels predict AF. We investigated whether there was an association between serum CRP levels and the development of AF.</P> <P><B>Methods</B></P> <P>A total of 10,030 subjects aged between 40 and 69 years were enrolled and followed biennially over a 12-year period in the Ansan-Ansung cohort study. Serum CRP levels were measured at baseline and high-sensitivity CRP (hsCRP) levels were measured at every revisit. AF was identified using 12-lead standard electrocardiography. Inverse probability of treatment weighting was applied to balance the confounders of AF development between groups.</P> <P><B>Results</B></P> <P>Serum CRP levels were higher in subjects with AF at baseline and those with new-onset AF than in those without AF. Cox-regression analysis showed that high CRP levels (>3 mg/L) and intermediate CRP levels (1–3 mg/L) at baseline were not associated with a higher risk of new-onset AF compared with low CRP levels (<1 mg/L) after adjustments for covariates. The weighted incidences of AF also did not differ according to the CRP levels. In contrast, persistent elevation of CRP or hsCRP levels (≥1 mg/L at all visits) was associated with a higher risk of AF compared with nonpersistent elevation of CRP or hsCRP levels after adjustment for covariates in both unweighted and weighted cohorts.</P> <P><B>Conclusion</B></P> <P>A high CRP level at a single measurement was not associated with the risk of AF, whereas persistently elevated CRP levels independently predicted the development of AF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Subjects with AF appeared to have higher CRP levels than those without AF. </LI> <LI> Single CRP elevation was not associated with the prevalence and incidence of AF. </LI> <LI> Persistent CRP elevation was independently associated with the risk of AF. </LI> <LI> These results support inflammatory hypothesis in AF pathogenesis. </LI> </UL> </P>